RNA damage and repair / / Ioly Kotta-Loizou, editor

• Pubblicazione: Cham, Switzerland : , : Springer, , [2021]; ©2021
• Descrizione fisica: 1 online resource (180 pages)
• Disciplina: 572.88
• Soggetto topico: RNA; DNA damage; ADN; Reparació de l'ADN; Biomolècules; Procariotes
• Soggetto genere / forma: Llibres electrònics
• Persona (resp. second.): Kotta-LoizouIoly
• Nota di bibliografia: Includes bibliographical references.
• Nota di contenuto: Intro -- Preface -- Contents -- Part I: RNA Damage and Repair in Prokaryotes -- Endoribonucleases of the Toxin-Antitoxin Systems Induce Abortive Infection -- 1 Introduction -- 1.1 The Arms Race Between Bacteria and Phages -- 1.2 The Abortive Infection (Abi) System -- 1.3 The Toxin-Antitoxin (TA) System -- 2 Functions, Structures, and Regulation of the MazF Endoribonuclease -- 2.1 The Abortive Infection Induced by the MazF Endoribonuclease -- 2.2 Phage Mechanism to Overcome MazF-Induced Abi -- 3 Functions, Structures, and Regulation of RnlA Endoribonuclease -- 3.1 The Abortive Infection Induced by RnlA Endoribonuclease -- 3.2 Phage Mechanisms to Overcome RnlA-Induced Abi -- 4 Functions, Structures, and Regulations of ToxN Endoribonuclease -- 4.1 The Abortive Infection Induced by ToxN Endoribonuclease -- 4.2 Phage Mechanisms to Overcome ToxN-Induced Abi -- 5 Conclusion -- References -- The Lifecycle of Ribosomal RNA in Bacteria -- 1 Introduction -- 2 Localisation and Copy Number of rDNA Operons in Bacteria -- 3 Organisation of rDNA Operons in Bacteria -- 4 Transcription Regulation of rDNA Genes Along the Microbial Growth Curve -- 4.1 Ribosomal DNA Promoters and Cis-Regulatory Elements -- 4.2 Trans-regulatory Elements -- 4.2.1 Regulation by Transcription Factors -- 4.2.2 Regulation by NTP and (p)ppGpp -- 5 Processing of Premature rRNA into Functional rRNAs -- 5.1 Maturation of 23S rRNA in E. coli -- 5.2 Maturation of 16S rRNA in E. coli -- 5.3 Maturation of 5S rRNA in E. coli -- 6 Bacterial rRNA Fragmentation -- 7 Chemical Modification of rRNA Molecules -- 8 Assembly of rRNAs into Ribosomes -- 9 rRNA Quality Control -- 10 Damage and Repair of Bacterial rRNA -- 11 Conclusion -- References -- The Rtc RNA End Healing and Sealing System -- 1 Introduction -- 2 Biological RNA Damage -- 2.1 CRISPR-Cas Systems -- 3 RNA Repair -- 4 The RtcA and RtcB Enzymes. ; 4.1 The RtcA RNA Cyclase -- 4.2 The RtcB RNA Ligase -- 4.3 The RtcB RNA Ligase in Prokaryotes -- 4.4 The RtcB RNA Ligase in Metazoans -- 5 The Bacterial Rtc RNA Repair System -- 5.1 Diversity of the rtc Operon in Bacteria -- 5.2 The RtcR Transcriptional Regulator and Its CARF Domain -- 5.3 Expression and Function of the Rtc System in Bacteria -- 6 Conclusions -- References -- Part II: RNA Damage and Repair in Eukaryotes -- Oxidative and Nitrative RNA Modifications in Plants -- 1 Introduction -- 2 Oxidative Modifications of RNA in Plants -- 3 Nitrative Modifications of RNA in Plants -- 4 Conclusions -- References -- The Role of Ribonucleases in RNA Damage, Inactivation and Degradation -- 1 Introduction -- 2 Quality Control Mechanisms to Manage Damaged RNA -- 3 Ribosome Quality Control (RQC) and No-Go-Decay (NGD) -- 4 Xrn1, a 5'-3' Exoribonuclease, and the Exosome, a 3'-5' Exoribonuclease Complex -- 5 Cue2 as a Potential NGD Endonuclease -- 6 The Role of Ribonucleases in Targeting and Inactivating Host and Foreign RNA -- 7 Regulatory RNase 1 (Regnase-1) -- 8 NEDD4-Binding Protein 1 (N4BP1) -- 9 Zinc Finger Antiviral Protein (ZAP) and Co-Factor Nucleases -- 10 ZAP and KHNYN -- 11 ZAP and the Exosome Complex -- 12 The 2',5'-Oligoadenylate Synthetase (OAS)/RNAse L System -- 13 Conclusion -- References -- Cytoplasmic mRNA Recapping: An Unexpected Form of RNA Repair -- 1 The Nature of the Cap and Its Role in mRNA Metabolism -- 2 Decapping and 5' Decay -- 3 Early Evidence for Uncapped and Recapped Transcripts -- 4 The Discovery of Cytoplasmic Capping -- 5 The Proteins of the Cytoplasmic Capping Complex -- 6 Cap Homeostasis as an RNA Repair Mechanism That Modulates Translation, mRNA Decay, and Translational Control -- 7 Is There a Relationship Between Recapped Ends and CAGE Tags? -- 8 Does Cytoplasmic Capping Impact the Proteome?. ; 9 Conclusion and Future Questions -- References -- Part III: RNA Damage in Human Diseases -- Adenosine-to-Inosine RNA Editing: A Key RNA Processing Step Rewriting Transcriptome in Normal Physiology and Diseases -- 1 Regulatory Mechanisms of A-to-I RNA Editing -- 1.1 Editing Regulation by Altering ADAR Expression and Activity -- 1.2 Editing Regulation by Affecting Subcellular Localization of ADAR -- 1.3 Additional Layers of A-to-I RNA Editing Regulation -- 2 Cross Talk of RNA Editing with Other RNA Processing and Cellular Pathways -- 2.1 Roles of ADARs and RNA Editing in miRNA Targeting and Biogenesis -- 2.2 ADARs and Splicing Regulation -- 2.3 ADAR Directly Promotes Proximal Polyadenylation Site -- 2.4 ADAR and N6-Methyladenosine -- 2.5 ADAR and Apoptosis -- 2.6 ADAR and Innate Immunity -- 2.7 ADAR2 and Circadian Rhythm -- References -- RNA-Mediated Metabolic Defects in Microsatellite Expansion Diseases -- 1 Overview of Microsatellite Expansion Diseases -- 2 RNA Structure and RNA-Mediated Toxicity -- 3 Repeat Associated Non-AUG Translation -- 4 Emerging Pathological Roles of microRNA -- 5 Defects in Nucleocytoplasmic Transport -- 6 Liquid-Liquid Phase Separation (LLPS) and Stress Granules -- 7 Conclusions and Future Perspectives -- References.
• Titolo autorizzato: RNA Damage and Repair
• ISBN: 3-030-76571-7
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910490024403321
• Lo trovi qui: Univ. Federico II