Biomarkers of disease : an evidence-based approach / / edited by Andrew K. Trull [and others] [[electronic resource]]

• Pubblicazione: Cambridge : , : Cambridge University Press, , 2002
• Descrizione fisica: 1 online resource (xxii, 494 pages) : digital, PDF file(s)
• Disciplina: 616.0756
• Soggetto topico: Biochemical markers; Clinical chemistry
• Persona (resp. second.): TrullAndrew K.
• Note generali: Title from publisher's bibliographic system (viewed on 05 Oct 2015).
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: Cover; Half-title; Title; Copyright; Contents; Contributors; Preface; 1 Evidence-based medicine: evaluation of biomarkers; 2 Development of biomarkers: the industrial perspective; 3 Statistical approaches to rational biomarker selection; 4 Using intelligent systems in clinical decision support; 5 Biomarkers in renal disease; 6 The genetics of renal disease; 7 Early markers of nephrotoxicity for environmental and occupational monitoring; 8 The early detection of renal impairment in diabetes mellitus. The case for microalbuminuria and other biomarkers ; 9 Bone turnover markers in clinical practice10 Biomarkers of bone formation; 11 Biochemical markers of bone resorption; 12 The clinical application of biomarkers in osteoporosis; 13 Sources of preanalytical variability in the measurement of biochemical markers of bone turnover; 14 Genetic approaches to the study of complex diseases: osteoporosis; 15 Biomarkers of hepatic disease; 16 The immunogenetics of metabolic liver disease; 17 Toxicogenetic markers of liver dysfunction; 18 Prognosis and management of patients with acute liver failure ; 19 Biomarkers in artificial and bioartificial liver support20 Prognostic markers in liver disease; 21 Apoptosis: biomarkers and the key role of mitochondria; 22 Liver regeneration: mechanisms and markers; 23 Determinants of responses to viruses and self in liver disease; 24 IL-6-type cytokines and signalling in inflammation; 25 Biomarkers in gastrointestinal disease; 26 Tumour markers in gastrointestinal cancer; 27 Markers of malabsorption: coeliac disease; 28 Genomics and biomarkers in toxicology; 29 Protein profiling and proteomic databases ; 30 Biomarkers for evaluating the safety of genetically modified foods31 The impact of biochemical tests on patient management; 32 Cardiac natriuretic peptides in risk assessment of patients with acute myocardial infarction or congestive heart failure; 33 Serum markers of inflammation and cardiovascular risk; 34 The clinical significance of markers of coagulation in acute coronary syndromes; 35 Endothelin: what does it tell us about myocardial and endothelial dysfunction?; 36 Homocysteine: a reversible risk factor for coronary heart disease ; 37 Matrix metalloproteinases and their tissue inhibitors38 Biomarkers of neurodegenerative disorders; 39 Traumatic brain injury: assessment by biochemical serum markers; 40 An overview of S-100Beta as a clinically useful biomarker of brain tissue damage; 41 Monitoring heart and lung transplant patients; 42 Monitoring liver transplant recipients; 43 Chronic allograft damage index as a surrogate marker for chronic allograft rejection; 44 Advances in pharmacodynamic biomarkers for monitoring the response to immunosuppressive drug therapy ; 45 The use of biomarkers for monitoring the response to immunosuppressive drug therapy
• Sommario/riassunto: This publication takes a critical, evidence-based look at the efficacy of diagnostic tests which are increasingly being used to evaluate organ damage and dysfunction. The use of biomarkers is growing, with a steady stream of products being brought out by the pharmaceutical industry. Some of these assist in diagnosis, others provide a means of monitoring the state of progression of disease and the effectiveness of therapeutic options. However, in many cases the evidence which supports the use of these methods as opposed to traditional biochemical tests has not yet been demonstrated, and it is intended that this volume will help clarify the strengths and weaknesses of using these biomarkers across a wide range of applications and in the various organs of the body. This approach will provide pathologists, clinical biochemists and medical laboratory scientists with an invaluable overview of the diverse applications of biomarkers in medicine.
• Titolo autorizzato: Biomarkers of disease
• ISBN: 1-107-13252-5; 1-280-16105-1; 9786610161058; 1-139-14780-3; 0-511-12018-4; 0-511-06438-1; 0-511-05805-5; 0-511-54596-7; 0-511-30714-4; 0-511-07284-8
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910450552203321
• Lo trovi qui: Univ. Federico II