Modeling and analysis of bio-molecular networks / / Jinhu LuÌ, Pei Wang

• Autore: LuÌ Jinhu
• Pubblicazione: Singapore : , : Springer, , [2020]; ©2020
• Edizione: 1st ed. 2020.
• Descrizione fisica: 1 online resource (XXI, 464 p. 144 illus., 123 illus. in color.)
• Disciplina: 572.8
• Soggetto topico: Molecular biology - Data processing; Computational biology; Bioinformatics
• Persona (resp. second.): WangPei <1958->
• Nota di contenuto: 1 Introduction and Preliminaries -- 2 Reconstruction of Bio-molecular Networks -- 3 Modeling and Analysis of Simple Genetic Circuits -- 4 Modeling and Analysis of Coupled Bio-molecular Circuits -- 5 Modeling and Analysis of Large-scale Networks -- 6 Evolutionary Mechanisms of Network Motifs in PPI Networks -- 7 Identifying Important Nodes in Bio-molecular Networks -- 8 Statistical Analysis of Functional Genes in Human PPI Networks -- 9 Data-driven Statistical Approaches for Omics Data Analysis.
• Sommario/riassunto: This book addresses a number of questions from the perspective of complex systems: How can we quantitatively understand the life phenomena? How can we model life systems as complex bio-molecular networks? Are there any methods to clarify the relationships among the structures, dynamics and functions of bio-molecular networks? How can we statistically analyse large-scale bio-molecular networks? Focusing on the modeling and analysis of bio-molecular networks, the book presents various sophisticated mathematical and statistical approaches. The life system can be described using various levels of bio-molecular networks, including gene regulatory networks, and protein-protein interaction networks. It first provides an overview of approaches to reconstruct various bio-molecular networks, and then discusses the modeling and dynamical analysis of simple genetic circuits, coupled genetic circuits, middle-sized and large-scale biological networks, clarifying the relationships between the structures, dynamics and functions of the networks covered. In the context of large-scale bio-molecular networks, it introduces a number of statistical methods for exploring important bioinformatics applications, including the identification of significant bio-molecules for network medicine and genetic engineering. Lastly, the book describes various state-of-art statistical methods for analysing omics data generated by high-throughput sequencing. This book is a valuable resource for readers interested in applying systems biology, dynamical systems or complex networks to explore the truth of nature.
• Titolo autorizzato: Modeling and analysis of bio-molecular networks
• ISBN: 981-15-9144-X
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910447244003321
• Lo trovi qui: Univ. Federico II