Biology in Stem Cell Niche / / edited by Kursad Turksen

• Pubblicazione: Cham : , : Springer International Publishing : , : Imprint : Springer, , 2015
• Edizione: 1st ed. 2015.
• Descrizione fisica: 1 online resource (239 p.)
• Disciplina: 616.02774
• Soggetto topico: Stem cells; Biomedical engineering; Stem Cells; Biomedical Engineering and Bioengineering
• Persona (resp. second.): TurksenKursad
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references at the end of each chapters and index.
• Nota di contenuto: Preface; Contents; Editor and Contributors; 1 The Hematopoietic Stem Cell Niche: Cell-Cell Interactions and Quiescence; 1 Introduction; 2 Cell-Cell Interactions; 2.1 Endothelial Cells; 2.2 Mesenchymal-Derived Cells of the Hematopoietic Stem Cell Niche; 2.2.1 Chemokine Ligand 12 Expressing Cells; 2.2.2 Nestin Expressing Cells; 2.2.3 Osteoblasts; 2.2.4 Leptin-Receptor Expressing Cells; 2.2.5 CD146 Expressing Cells; 2.2.6 Bone Cartilage Stromal Progenitor Cells; 3 Other Niche Cells; 3.1 Megakaryocytes; 3.1.1 Non-myelinated Schwann Cells; 3.1.2 Monocytes/Macrophages ; 3.1.3 Sympathetic Nervous System4 Hematopoietic Stem Cell Niche Structure and Physiology; 4.1 Integrins; 4.2 Wnts; 4.3 Hypoxia; 4.4 Energetics; 5 Intrinsic Regulators of Cell Cycle; 6 Conclusions; Acknowledgments; References; 2 The Mammalian Limbal Stem Cell Niche: A Complex Interaction Between Cells, Growth Factors and Extracellular Matrix; 1 Introduction; 2 Defining the Limbus as the Residence Site for Corneal Stem Cells; 3 The Limbus: Its Structure and Composition; 3.1 Corneal Epithelial Stem Cells and Their Niche: Cells that Interact with the Limbal Stem Cell Reservoir ; 3.1.1 Epithelial Cells3.1.2 Melanocytes; 3.1.3 Langerhans' Cells; 3.1.4 Stromal Cells; 3.1.5 Corneal Innervation; 3.2 Corneal Epithelial Stem Cells and Their Niche: Basal Membrane and Extracellular Matrix Components; 3.3 Corneal Epithelial Stem Cells and Their Niche: Growth Factors and Cytokines; 4 The Niche as Regulator of Limbal Stem Cells; 5 Corneal Epithelial Stem Cells: Renewal and Wound Healing; 6 Limbal Stem Cells and Therapy; 7 Conclusion; Acknowledgements; References; 3 Emerging Engineering Strategies for Studying the Stem Cell Niche; 1 Introduction; 2 Stem Cells and Their Niches ; 3 Stem Cell-ECM Interactions3.1 Stem Cell Adhesion to Niche ECM via Integrins; 3.2 Cadherins, Another Class of Adhesion Receptors; 3.3 Molecular Sequestering of Growth Factors and Cytokines by ECM; 4 Seminal Engineering Strategies---Establishing a Foundation; 4.1 Micro/Nanofabrication Techniques for Generating Pre-Printed Topographies; 4.2 Micropatterning Techniques to Relate Stem Cell Shape to Behavior; 4.3 Soft Matter Hydrogel Systems with Predefined Characteristics; 5 Second Generation Engineering Strategies---Increased Complexity with a Focus on Spatiotemporal Control ; 5.1 Biomaterials with Tunable Properties5.2 Spatiotemporal Control over Topography; 5.3 Spatiotemporal Control over Matrix Stiffness; 5.4 Dynamic Control of Integrin-Based Focal Adhesions; 6 Dissecting Cell-Cell Interactions within the Stem Cell Niche; 7 Early Approaches for Studying Stem Cell-Niche Cell Interactions In Vitro; 7.1 Patterned Bulk Stem Cell Co-Cultures; 7.2 Patterned 3D Stem Cell Co-Cultures; 8 Shifting Focus to Single-Cell Resolution and Artificial Niches; 8.1 Microfluidic Approaches for Single-Cell Co-Cultures; 8.2 Artificial Stem Cell-Niche Cell Signaling Approaches ; 9 Conclusions and Future Directions
• Sommario/riassunto: This comprehensive volume explores functions, pathologies, and applications of stem cells in relation to the niches in which they develop. Ten chapters cover the subject in depth, from a historical perspective through signaling, hormonal control, quiescence, biomimetics, epigenetics, engineering strategies for emulating, tumorigenesis and more. The chapter authors represent a broad range of international expertise and perspectives. This installment of the popular Stem Cell Biology and Regenerative Medicine series delivers authoritative, international perspectives on this rapidly growing field. Biology of Stem Cell Niche is an ideal complementary volume to Tissue-Specific Stem Cell Niche and Adult Stem Cells, Second Edition and will be invaluable to clinicians and researchers working with stem cells as well as to postgraduate trainees who are studying them.
• Titolo autorizzato: Biology in Stem Cell Niche
• ISBN: 3-319-21702-X
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910298266103321
• Lo trovi qui: Univ. Federico II
• Serie: Stem Cell Biology and Regenerative Medicine, . 2196-8985