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[null,"1.","Record Nr.",null,"UNINA9910459222003321"]
[null,null,"Titolo",null,"Methods in bioengineering : alternatives to animal testing / / Tim Maguire, Eric Novik, editors"]
[null,null,"Pubbl/distr/stampa",null,"Boston, Massachusetts : , : Artech House, , ©2010"]
[{"$nulls":4},"[Piscataqay, New Jersey] : , : IEEE Xplore, , [2010]"]
[null,null,"ISBN",null,"1-60807-012-3"]
[null,null,"Descrizione fisica",null,"1 online resource (298 p.)"]
[null,null,"Collana",null,"Methods in bioengineering series"]
[null,null,"Disciplina",null,"179.4"]
[null,null,"Soggetti",null,"Animal experimentation - Moral and ethical aspects"]
[{"$nulls":4},"Animal welfare - Moral and ethical aspects"]
[{"$nulls":4},"Human-animal relationships - Moral and ethical aspects"]
[{"$nulls":4},"Electronic books."]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references and index."]
[null,null,"Nota di contenuto",null,"Contents; Preface; Chapter 1 Current Methods for Prediction of Human Hepatic Clearance Using In Vitro Intrinsic Clearance; 1.1 Introduction; 1.2 Materials; 1.3 Methods; 1.3.1 Thawing the hepatocytes; 1.3.2 Clearance study using a hepatocyte suspension; 1.3.3 Clearance study using a plated hepatocyte culture; 1.3.4 Clearance study using a plated hepatocyte culture under a flow condition; 1.3.5 Sampling for the clearance study; 1.3.6 Sample analysis using LC-MS/MS; 1.4 Data Acquisition, Anticipated Results, and Interpretation; 1.4.1 Hepatocyte suspension and plated hepatocyte system"]
[{"$nulls":4},"1.4.2 Physiologically based microfluidic systems1.5 Discussion and Commentary; 1.5.1 Hepatocyte suspension system; 1.5.2 Plated hepatocyte system; 1.5.3 Physiologically based microfluidic systems; 1.6 Summary; References; Chapter 2 Use of Permeability from Cultured Cell Linesand PAMPA System and Absorption from Experimental Animals for the Prediction of Absorption in Humans; 2.1 Introduction; 2.2 Materials; 2.3 Methods; 2.3.1 Cultured cell system; 2.3.2 PAMPA system; 2.3.3 In vivo absorption measurements; 2.4 Data Acquisition, Anticipated Results, and Interpretation; 2.4.1 Data analysis"]
[{"$nulls":4},"2.4.2 Results and interpretation2.5 Discussion and Commentary; 2.5.1 Cell culture and PAMPA systems; 2.5.2 Absorption in experimental animals; 2.5.3 Rats; 2.5.4 Dogs; 2.5.5 Monkeys; 2.6 Summary; References; Chapter 3 Aggregating Brain Cell Cultures for Neurotoxicity "]
[{"$nulls":4},"Tests; 3.1 Introduction; 3.2 Experimental Design; 3.3 Materials; 3.3.1 Animals; 3.3.2 Special equipment; 3.3.3 Reagents; 3.3.4 Preparation of solutions and media; 3.4 Methods; 3.4.1 Washing and sterilizing the glassware; 3.4.2 Cell isolation and culture preparation"]
[{"$nulls":4},"3.4.3 Maintenance of aggregating brain cell cultures (media replenishmentand subdivision)3.4.4 Preparation and treatment of replicate cultures; 3.4.5 Harvest of replicate cultures for various analytical procedures; 3.4.6 Examples of sample preparation and use for various analytical procedures; 3.4.7 Data Analysis; 3.5 Anticipated Results; 3.6 Discussion and Commentary; 3.7 Application Notes; 3.8 Summary Points; Acknowledgments; References; Chapter 4 Approaches Towards a Multiscale Model of Systemic Inflammation in Humans; 4.1 Introduction; 4.2 Materials"]
[{"$nulls":4},"4.2.1 Human endotoxin model and data collection4.3 Methods; 4.3.1 Transcriptional dynamics and intrinsic responses; 4.3.2 Modeling inflammation at the cellular level; 4.3.3 Modeling inflammation at the systemic level; 4.4 Results; 4.4.1 Elements of the multiscale host response model of human inflammation; 4.4.2 Estimation of relevant model parameters; 4.4.3 Qualitative assessment of the model; 4.5 Conclusions; Acknowledgments; References; Chapter 5 A Liposome Assay for Evaluating the Ocular Toxicity of Chemicals; 5.1 Introduction; 5.2 Experimental Design; 5.3 Materials; 5.4 Methods"]
[{"$nulls":4},"5.4.1 Preparation of calcein-loaded liposomes"]
[null,null,null,"Sommario/riassunto","Written and edited by recognized experts in the field, the new Artech House Methods in Bioengineering book series offers detailed guidance on authoritative methods for addressing specific bioengineering challenges. Offering a highly practical presentation of each topic, each book provides research engineers, scientists, and students with step-by-step procedures, clear examples, and effective ways to overcome problems that may be encountered. Providing alternatives to animal testing is one of the hottest topics in biomedical research, and this groundbreaking volume addresses this critical issues head on. This unique book presents techniques and methods at the forefront of scientific research that have the potential to replace certain whole animal tests. Moreover, this book provides a platform where other widely accepted techniques and scientific advancements can be collated into a concise set of methods that can be implemented within both academic and industrial communities."]
[null,"2.","Record Nr.",null,"UNISALENTO991000197599707536"]
[null,null,"Autore",null,"Briggs, Martin S."]
[null,null,"Titolo",null,"Storia di Lecce : Nel tallone d'Italia / Martin S. Briggs ; a cura di Mario De Marco"]
[null,null,"Pubbl/distr/stampa",null,"Cavallino : Capone, 1980"]
[null,null,"Descrizione fisica",null,"XXVI, 406 p. ; 21 cm."]
[null,null,"Collana",null,"Itinerari meridionali ; 5"]
[null,null,"Disciplina",null,"945.753"]
[null,null,"Soggetti",null,"Architettura - Lecce"]
[{"$nulls":4},"Lecce - Storia"]
[null,null,"Lingua di pubblicazione",null,"Italiano"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Tit. orig.: In the heel of Italy"]
[null,"3.","Record Nr.",null,"UNINA9910724401303321"]
[null,null,"Autore",null,"Tütken Johannes"]
[null,null,"Titolo",null,"Privatdozenten im Schatten der Georgia Augusta . Teil II Biographische Materialien zu den Privatdozenten des Sommersemesters 1812 : zur älteren Privatdozentur (1734 bis 1831) / / Johannes Tütken"]
[null,null,"Pubbl/distr/stampa",null,"Göttingen : , : Universitätsverlag Göttingen, , 2005"]
[null,null,"Descrizione fisica",null,"1 online resource (533 pages) : illustrations"]
[null,null,"Disciplina",null,"001.3"]
[null,null,"Soggetti",null,"Humanities - History"]
[null,null,"Lingua di pubblicazione",null,"Tedesco"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Nota di bibliografia","Includes bibliographical references and index."]
[null,null,null,"Sommario/riassunto","Die Darstellung der Institution »ältere Privatdozentur« im ersten Teil wird im zweiten Band durch biographische Skizzen von 32 Privatdozenten des Sommersemesters 1812 ergänzt. Sie verdeutlichen, dass die Privatdozentur nur für wenige eine Pflanzschule künftiger Professoren war, als die sie der Göttinger Orientalist Michaelis 1773 bezeichnete - nur sechs Privatdozenten erreichten eine Professur. Der Regelfall war ein nicht habilitierter Privatlehrer ohne Berufungsaussicht, der mit seinem Zweitberuf den gehaltlosen Privatdozenten in sich ernährte. Das Karrierespektrum in der gewählten Stichprobe ist weit gefächert: es reicht von dem bedeutenden Arabistikprofessor G. W. Freytag an der Universität Bonn bis zum örtlichen Notar J. G. Quentin, der am Rande des akademischen Proletariats stand, bis hin zu dem jung dahingegangenen Autor Ernst Schulze, der für Cäcilie Tychsen einfühlsame Poesie schrieb und posthum zu einem Lieblingsdichter seiner Zeit wurde. Die Stichprobe schließt den Friseurgesellen Ch. Focke ein, der sich zum Mathematikdozenten aufschwang, sowie den Musicus J. N. Forkel, einen Mitbegründer der Musikwissenschaft. Die Arbeit beruht vor allem auf den Akten des Universitätsarchivs und führt daher viele Aspekte des alltäglichen Mit- und Gegeneinanders an der Georgia Augusta auf, die im ausführlichen Personen- und Sachregister aufgeführt sind. Abgerundet werden die Einsichten in den akademischen Alltag durch den Blick auf andere Universitäten: von Salamanca, zu dessen Promotionsbräuchen auch der Stierkampf gehörte, bis hin zur Erfurter Universität, an der man eine Promotion "]
[{"$nulls":4},"kaufen konnte und darüber hinaus auf W. von Humboldts Neugründung, die sich 1810 am östlichen Horizont zeigte."]