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[null,"1.","Record Nr.",null,"UNISA996386495603316"]
[null,null,"Autore",null,"Elys Edmund <ca. 1634-ca. 1707>"]
[null,null,"Titolo",null,"A complaint of Edmund Elys, a minister of the gospel of Jesus Christ [[electronic resource] ] : against Titus Oates. To the nobility and gentry of England"]
[null,null,"Pubbl/distr/stampa",null,"[S.l., : s.n., 1696?]"]
[null,null,"Descrizione fisica",null,"4 p"]
[null,null,"Soggetti",null,"Great Britain History Restoration, 1660-1688 Early works to 1800"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Caption title."]
[{"$nulls":4},"Imperfect: creased, print show-through with loss of text."]
[{"$nulls":4},"Reproduction of original in: Bodleian Library."]
[null,null,null,"Sommario/riassunto","eebo-0014"]
[null,"2.","Record Nr.",null,"UNINA9910367740903321"]
[null,null,"Autore",null,"Pulido Rafael"]
[null,null,"Titolo",null,"Dual Specificity Phosphatases: From Molecular Mechanisms to Biological Function"]
[null,null,"Pubbl/distr/stampa",null,"MDPI - Multidisciplinary Digital Publishing Institute, 2019"]
[null,null,"ISBN",null,"3-03921-689-9"]
[null,null,"Descrizione fisica",null,"1 online resource (240 p.)"]
[null,null,"Soggetti",null,"Biology, life sciences"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Sommario/riassunto","Dual specificity phosphatases (DUSPs) constitute a heterogeneous group of protein tyrosine phosphatases with the ability to dephosphorylate Ser/Thr and Tyr residues from proteins, as well as from other non-proteinaceous substrates including signaling lipids. DUSPs include, among others, MAP kinase (MAPK) phosphatases (MKPs) and small-size atypical DUSPs. MKPs are enzymes specialized in regulating the activity and subcellular location of MAPKs, whereas the function of small-size atypical DUSPs seems to be more diverse. DUSPs have emerged as key players in the regulation of cell growth, differentiation, stress response, and apoptosis. DUSPs regulate essential physiological processes, including immunity, neurobiology and metabolic homeostasis, and have been implicated in tumorigenesis, pathological inflammation and metabolic disorders. Accordingly, alterations in the expression or function of MKPs and small-size atypical DUSPs have consequences essential to human disease, making these enzymes potential biological markers and therapeutic targets. This Special Issue covers recent advances in the molecular mechanisms and biological functions of MKPs and small-size atypical DUSPs, and their relevance in human disease."]