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[null,"1.","Record Nr.",null,"UNISA996218390403316"]
[null,null,"Autore",null,"Kubinyi Hugo"]
[null,null,"Titolo",null,"QSAR : Hansch analysis and related approaches [[electronic resource] /] / by Hugo Kubinyi"]
[null,null,"Pubbl/distr/stampa",null,"Weinheim ; ; New York, : VCH, c1993"]
[null,null,"ISBN",null,"1-281-75888-4"]
[{"$nulls":4},"9786611758882"]
[{"$nulls":4},"3-527-61682-9"]
[{"$nulls":4},"3-527-61683-7"]
[null,null,"Descrizione fisica",null,"1 online resource (254 p.)"]
[null,null,"Collana",null,"Methods and principles in medicinal chemistry ; ; v. 1"]
[null,null,"Disciplina",null,"572.072"]
[{"$nulls":4},"615"]
[{"$nulls":4},"615.1901"]
[null,null,"Soggetti",null,"QSAR (Biochemistry)"]
[{"$nulls":4},"Pharmaceutical chemistry"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references (p. [183]-210) and index."]
[null,null,"Nota di contenuto",null,"QSAR: Hansch Analysis and Related Approaches; Content; 1. Introduction; 1.1. History and Development of QSAR; 1.2. Drug-Receptor Interactions; 2. Biological Data. The Additivity of Group Contributions; 3. Parameters; 3.1. Lipophilicity Parameters; 3.2. The Measurement of Partition Coefficients and Related Lipophilicity Parameters; 3.3. Lipophilicity Contributions and the Calculation of Partition Coefficients; 3.4. Polarizability Parameters; 3.5. Electronic Parameters; 3.6. Steric Parameters; 3.7. Other Parameters; 3.8. Indicator Variables; 4. Quantitative Models"]
[{"$nulls":4},"4.1. The Extrathermodynamic Approach (Hansch Analysis)4.2. The Additivity Model (Free Wilson Analysis); 4.3. The Relationships between Hansch and Free Wilson Analysis (The Mixed Approach); 4.4. Nonlinear Relationships; 4.5. Dissociation and Ionization of Acids and Bases; 4.6. Other QSAR Approaches; 5. Statistical Methods; 5.1. Regression Analysis; 5.2. The Significance and Validity of QSAR Regression Equations; 5.3. Partial Least Squares (PLS) Analysis and Other Multivariate Statistical Methods; 6. Design of Test Series in QSAR; 7. Applications of Hansch Analysis; 7.1. Enzyme Inhibition"]
[{"$nulls":4},"7.2. Other in vitro Data7.3. Pharmacokinetic Data; 7.4. Other Biological Data; 7.5. Activity-Activity Relationships; 8. Applications of Free Wilson "]
[{"$nulls":4},"Analysis and Related Models; 9. 3D QSAR Approaches; 9.1. Stereochemistry and Drug Action; 9.2. Active Site Interaction Models; 9.3. Comparative Molecular Field Analysis (CoMFA); 9.4. Molecular Similarity QSAR Analyses; 10. Summary and Conclusions; References; Index"]
[null,null,null,"Sommario/riassunto","Finding the new remedy for a certain disease: an inspired goal. QSAR, an invaluable tool in drug design, aids scientists to attain this aim.This book is a long-awaited comprehensive text to QSAR and related approaches. It provides a practice-oriented introduction to the theory, methods and analyses for QSAR relationships, including modelling-based and 3D approaches.Hugo Kubinyi is a leading expert in QSAR. Readers will benefit from the author's 20 years of practical experience, from his careful calculations and recalculations of thousands of QSAR equations. Among the topics cov"]