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[null,"1.","Record Nr.",null,"UNISA996218292203316"]
[null,null,"Autore",null,"Maroni Gustavo"]
[null,null,"Titolo",null,"Molecular and genetic analysis of human traits [[electronic resource] /] / Gustavo Maroni"]
[null,null,"Pubbl/distr/stampa",null,"Malden, MA, : Blackwell Science, c2001"]
[null,null,"ISBN",null,"1-281-32161-3"]
[{"$nulls":4},"9786611321611"]
[{"$nulls":4},"0-470-76007-9"]
[{"$nulls":4},"0-470-75980-1"]
[null,null,"Descrizione fisica",null,"1 online resource (296 p.)"]
[null,null,"Disciplina",null,"599.935"]
[null,null,"Soggetti",null,"Human genetics"]
[{"$nulls":4},"Medical genetics"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references and index."]
[null,null,"Nota di contenuto",null,"Contents; PREFACE; CHAPTER 1 The Inheritance of Simple Mendelian Traits in Humans; DETECTING MENDELIAN INHERITANCE IN HUMANS; Test-Crosses and Pure Lines versus Pedigrees and Inferred Genotypes; Box 1.1 Early observations of Mendelian inheritance in humans; PATTERNS OF INHERITANCE AND EXAMPLES; Autosomal Dominant Traits; Autosomal Recessive Traits; X-Linked Recessive Traits; THE USE OF PEDIGREES TO PREDICT THE RESULTS OF MATINGS; Probability of Individual Genotypes; Probability of Group Outcomes; GATHERING DATA TO TEST THE MODE OF INHERITANCE OF A TRAIT"]
[{"$nulls":4},"Pooling Data from Many Families and Ascertainment ErrorsAscertainment errors in studies of dominant traits; Ascertainment errors in studies of recessive traits; INHERITANCE OF MULTIPLE TRAITS: INDEPENDENT ASSORTMENT AND LINKAGE; Determination of Linkage from Human Pedigrees; Genetic Recombination and LOD Scores; Informative and Noninformative Matings; Neutral Polymorphisms, Marker Loci, and Genetic Maps; Box 1.2 Internet sites; The use of protein products to define marker loci; The use of directly detected DNA differences as marker lod"]
[{"$nulls":4},"EXAMPLE 1.1 Linkage of the Huntington's disease gene to an RFLPCONCLUSION; EXERCISES; REFERENCES; CHAPTER 2 Hereditary Traits That Do Not Show a Simple Mendelian Pattern; SINGLE-GENE TRAITS LACKING A SIMPLE MENDEUAN PATTERN; Variable Exprrssiviy "]
[{"$nulls":4},"and Incomplete Penetrance; Complementation; Phenocopies and Pleiotropy; QUANTITATIVE TRAITS; Multiple Alleles; Polygenic Inheritance; Major and Minor Genes; COMPLEX TRAITS; Epidemiological Analysis of Complex Traits; Liability; Family Clustering; Identical Twins; LOCALIZATION OF GENES RESPONSIBLE FOR COMPLEX AND QUANTITATIVE TRAITS"]
[{"$nulls":4},"Linkage Analysis of Complex TraitsAffected Pedigree Member (APM) or Allele-Sharing Methods; Example 2.1. Familial psoriasis; Example 2.2. Familial breast cancer; Analysis of quantitative trait loci by allele-sharing methods; Example 2.3. Insulin-dependent diabetes mellitus; Example 2.4. Male homosexuality; Allelic Association; Example 2.5. Dyslexia; Candidate Gene; Example 2.6. Nonsyndromal autosomal recessive deafness; Example 2.7. Neuroticism and genes for serotonin metabolism; CONCLUSION: NATURE VERSUS NURTURE; EXERCISES; REFERENCES; CHAPTER 3 Genome Organization I"]
[{"$nulls":4},"UNEXPRESSED DNA, REPETITIVE AND UNIQUE SEQUENCESClustered, Highly Repetitive Sequences; The main families of highly repetitive sequences; Example 3.1. The a family of highly repetitive DNA; Small-Cluster, Intermediately Repeated DNA; Minisatellite DNA; Microsatellite DNA; Dispersed, Intermediately Repeated Sequences; Viral retrotransposons; Nonviral retrotransposons: Alu, L1, and processed pseudogenes; Unique Sequence DNA; EXPRESSED DNA, GENES AND GENE FAMILIES; The Organization of RNA Polymerase I1 Genes: Intmns and Exons; Box 3.1. Internet sites; Example 3.2. Collagen"]
[{"$nulls":4},"Example 3.3. Cystic fibrosis"]
[null,null,null,"Sommario/riassunto","Molecular and Genetic Analysis of Human Traits will address the science student human genetics market. Although incorporating two basic themes: how do we establish that a trait is hereditary, and how is the human genome organized, it will also address relevant clinical examples and key related ethical issues. New attractive features have been added, including a chapter project, and end of chapter exercises which rely on real data. Each chapter includes end of chapter exercises, and references. In-text examples and internet references are cited. Most figur"]