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[null,"1.","Record Nr.",null,"UNINA9910136501303321"]
[null,null,"Titolo",null,"2016 3rd International Conference on Advances in Computational Tools for Engineering Applications (ACTEA) / / Institute of Electrical and Electronics Engineers"]
[null,null,"Pubbl/distr/stampa",null,"Piscataway, NJ : , : IEEE, , 2016"]
[null,null,"ISBN",null,"1-4673-8523-9"]
[null,null,"Descrizione fisica",null,"1 online resource (50 pages)"]
[null,null,"Disciplina",null,"620.00151"]
[null,null,"Soggetti",null,"Engineering - Data processing"]
[{"$nulls":4},"Computer-aided design"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Sommario/riassunto","The program of the conference ACTEA 16 aims at bringing together researchers and companies involved in computational research to advance the state of knowledge by sharing research results and pioneering views about recent trends and developments."]
[null,"2.","Record Nr.",null,"UNINA9911049063503321"]
[null,null,"Autore",null,"Gukasyan Hovhannes J"]
[null,null,"Titolo",null,"Antibody Drug Conjugates : Design, Discovery, and Development / / edited by Hovhannes J. Gukasyan, Ashutosh Kulkarni"]
[null,null,"Pubbl/distr/stampa",null,"Cham : , : Springer Nature Switzerland : , : Imprint : Springer, , 2026"]
[null,null,"ISBN",null,"3-031-89319-0"]
[null,null,"Edizione",null,"[1st ed. 2026.]"]
[null,null,"Descrizione fisica",null,"1 online resource (306 pages)"]
[null,null,"Collana",null,"AAPS Advances in the Pharmaceutical Sciences Series, , 2210-738X ; ; 52"]
[null,null,"Disciplina",null,"615.36"]
[null,null,"Soggetti",null,"Pharmacology"]
[{"$nulls":4},"Pharmacy"]
[{"$nulls":4},"Pharmaceutical chemistry"]
[{"$nulls":4},"Pharmaceutics"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,"Nota di contenuto",null,"Commercialized ADCs: A Market Snapshot for Exemplification -- Application of ADCs to Therapeutic Areas Outside of Oncology -- Regulatory framework for the manufacturing and marketing of ADCs -- Conjugation Chemistry and Chemical Design for the Discovery and Development of Antibody Drug Conjugates -- Clinical Pharmacology Considerations in Antibody-Drug Conjugates Development -- Bioanalytical Methodologies for Pharmacokinetic Characterization of Antibody Drug Conjugates -- Toxicology Considerations on Antibody-Drug Conjugate Discovery and Development -- Considerations for Antibody Drug Conjugate Design Stability and Formulation."]
[null,null,null,"Sommario/riassunto","This volume provides a comprehensive recapitulation of structure-activity relationship (SAR) from a mechanism of action point of view for this unique therapeutic modality, in a largely disease agnostic manner. From a disease biology and pharmacology perspective, the cellular target and drug-conjugate selection, considerations on liker -chemistry and -antibody ratio, and formulation science and technology, to get from bench to bedside (i.e. from a laboratory to the systemic circulation in a patient). The book also provides an understanding around target binding and drug/\"payload\" release mechanisms. Furthermore, pharmacokinetic and safety pharmacological aspects from a regulatory and clinical perspective are discussed, along with current chemistry, manufacturing, controls guidance and emerging novel "]
[{"$nulls":4},"delivery devices or technologies. The key differentiation in Antibody Drug Conjugates is the clinical and development discussion, that offers pragmatic considerations in medical product development, IP, regulatory considerations, among others. Furthermore, we discuss the topic as a platform, in a disease agnostic manner."]