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[null,"1.","Record Nr.",null,"UNINA9911020225303321"]
[null,null,"Titolo",null,"Pharmacology in veterinary anesthesia and analgesia / / edited by Turi Aarnes and Phillip Lerche"]
[null,null,"Pubbl/distr/stampa",null,"Newark : , : John Wiley & Sons, Incorporated, , 2024"]
[{"$nulls":4},"©2024"]
[null,null,"ISBN",null,"9781118975145"]
[{"$nulls":4},"1118975146"]
[{"$nulls":4},"9781118975169"]
[{"$nulls":4},"1118975162"]
[null,null,"Edizione",null,"[1st ed.]"]
[null,null,"Descrizione fisica",null,"1 online resource (430 pages)"]
[null,null,"Disciplina",null,"636.089/796"]
[null,null,"Soggetti",null,"Anesthesia - veterinary"]
[{"$nulls":4},"Analgesia - veterinary"]
[{"$nulls":4},"Anesthetics - pharmacology"]
[{"$nulls":4},"Anesthetics - adverse effects"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,"Nota di contenuto",null,"Cover -- Title Page -- Copyright Page -- Dedication Page -- Contents -- List of Contributors -- Preface -- Chapter 1 Pharmacokinetics and Pharmacodynamics -- Introduction -- Pharmacokinetics -- Absorption and Bioavailability -- Distribution -- Metabolism (Biotransformation) -- Elimination -- Pharmacokinetic Models -- Pharmacodynamics -- Receptors -- Pharmacokinetic/Pharmacodynamic Modeling -- References -- Further Reading -- Chapter 2 Pharmacogenetics in Veterinary Anesthesia and Analgesia -- Introduction -- Pharmacogenetics - Historical Perspectives -- Pharmacogenetics - Current Situation -- Pharmacogenetics - Cytochrome P450 Function -- Genetic Variations in Drug Disposition -- Pharmacogenomics of Drug Metabolism in Veterinary Patients - Polymorphisms of CYP450 -- Cytochrome P450 1A2 -- Cytochrome P450 2B -- Cytochrome P450 2C -- Cytochrome P450 2D -- Cytochrome P450 2E -- Cytochrome P450 3A -- Other Polymorphisms of Relevance Based upon Clinically Recognized Phenomena - Drug Transporters -- Feline Hypokalemia -- Inherited Ventricular Arrhythmias and Sudden Death of German Shepherd Dogs -- Opioids and Other Polymorphisms -- References -- Chapter 3 Veterinary Regulatory Concerns Associated with Anesthesia "]
[{"$nulls":4},"and Analgesia for Food Animals -- Introduction -- The Drug Approval Process and Animals -- Extra-Label Drug Use -- The Withdrawal Time, Tolerance and Withdrawal Interval -- Establishment of the Extended Withdrawal Interval -- Anesthetic Drugs - General Characteristics -- Analgesic Drugs -- Precautionary Comments - Euthanasia -- References -- Chapter 4 α2 Receptor Agonists and Antagonists -- Introduction -- α2 Receptors -- Sedative and Analgesic Effects -- Cardiovascular Effects -- Respiratory Effects -- Other Organ Effects -- Contraindications -- Specific α2 Receptor Agonists -- Clonidine -- Xylazine -- Detomidine -- Medetomidine."]
[{"$nulls":4},"Dexmedetomidine -- Romifidine -- α2 Receptor Antagonists -- Yohimbine -- Tolazoline -- Atipamezole -- Vatinoxan -- References -- Chapter 5 Phenothiazines and Butyrophenones -- Mechanism of Action -- Pharmacokinetics of Acepromazine in Major Species (Awake and Under Anesthesia) -- Dogs -- Horses -- Metabolism -- Clinical Use -- Dogs and Cats -- Horses -- Pigs -- Ruminants -- Effect in Patients Under General Anesthesia -- Effects on Organ Systems -- Cardiovascular System -- Respiratory System -- Central Nervous System -- Renal System -- Other Effects -- References -- Chapter 6 Benzodiazepines -- Introduction -- Structures and Mechanisms of Action -- Molecular Structure of Benzodiazepines -- Benzodiazepine Interaction with GABAA Receptors -- Pharmacokinetic Properties -- Routes of Administration -- Protein Binding -- Metabolism -- Excretion -- Indications and Pharmacodynamic Effects -- Hypnotic and Anxiolytic -- Anesthetic Sparing -- Anticonvulsant and Central Nervous System Effects -- Muscle Relaxation -- Amnesic Effects -- Appetite Stimulation -- Side Effects -- Respiratory and Cardiovascular -- Analgesic Effects -- Hepatic Necrosis -- Drug Interaction -- Dependence -- Aging -- Laryngeal Function -- Propylene Glycol -- Pregnancy -- Diazepam Hydrochloride -- Midazolam Maleate -- Lorazepam -- Remimazolam (also Known as CNS 7056) -- Flumazenil -- References -- Chapter 7 Opioid Agonists and Antagonists -- Introduction -- Mechanism of Action -- Pharmacokinetics -- Pharmacodynamics -- Nervous System Effects - Analgesia -- CNS Sedation and Excitation -- Ocular Effects -- Cardiovascular Effects -- Respiratory Effects -- Gastrointestinal Effects -- Urinary Effects -- Integumentary Effects -- Thermoregulatory Effects -- Effect on Inhalant Anesthetic Requirement -- Interactions with Sedatives -- Interactions with Selective Serotonin Reuptake Inhibitors."]
[{"$nulls":4},"Opioid Agonists -- Fentanyl Derivatives and Remifentanil -- Opioid Partial Agonist -- Opioid Agonist-Antagonists -- Opioid Antagonists -- References -- Chapter 8 Barbiturates -- Introduction -- Physicochemical Characteristics -- Pharmacokinetics -- Metabolism -- Mechanism of Action -- Pharmacodynamics -- Effects on Cerebral Metabolism -- Effects on Cardiovascular System -- Effects on the Respiratory System -- Other Effects -- Clinical Use in Veterinary Medicine -- Thiopental -- Methohexital -- Pentobarbital Sodium -- References -- Chapter 9 Induction Drugs -- Introduction -- Propofol -- Mechanism of Action -- Pharmacokinetics -- Metabolism -- Clinical Uses -- Effects on Organ Systems -- Cardiovascular -- Respiratory -- Central Nervous System -- Other Effects -- Contraindications -- Drug Interactions -- Alfaxalone -- Mechanism of Action -- Pharmacokinetics -- Metabolism -- Clinical Uses -- Effects on Organ Systems -- Cardiovascular -- Respiratory -- Central Nervous System -- Other Effects -- Contraindications -- Drug Interactions -- Dissociative Anesthetics (Ketamine and Tiletamine) -- Mechanism of Action -- Pharmacokinetics -- Metabolism -- Clinical Uses -- Effects on Organ Systems -- Cardiovascular -- Respiratory -- Central Nervous System -- "]
[{"$nulls":4},"Other Effects -- Contraindications -- Drug Interactions -- Etomidate -- Mechanism of Action -- Pharmacokinetics -- Metabolism -- Clinical Uses -- Effects on Organ Systems -- Cardiovascular -- Respiratory -- Central Nervous System -- Other Effects -- Contraindications -- Drug Interactions -- Miscellaneous Induction Agents -- Chloral Hydrate -- Alpha-Chloralose -- Urethane -- References -- Chapter 10 Inhalant Anesthetic Agents -- Introduction -- Chemical Structure -- Physical and Chemical Properties of Inhalant Anesthetics -- Mechanism of Action -- Solubility -- Potency -- Pharmacokinetics."]
[{"$nulls":4},"Pharmacodynamics of the Volatile Anesthetics -- Nitrous Oxide -- References -- Chapter 11 Non-Steroidal Anti-Inflammatory Drugs -- Introduction -- Pharmacology -- Mechanism of Action -- Classification -- Adverse Effects -- Gastrointestinal -- Kidney -- Coagulation -- Liver -- Interaction with Steroids -- Acetaminophen -- Aspirin -- Carprofen -- Deracoxib -- Etodolac -- Firocoxib -- Flunixin Meglumine -- Grapiprant -- Ketoprofen -- Meloxicam -- Phenylbutazone -- Piroxicam -- Robenacoxib -- References -- Chapter 12 Local Anesthetics -- Pharmacology of Local Anesthetics -- Neural Blockade -- Nerve Classification -- Nerve Blockade -- Other Factors that Influence Local Anesthetic Activity -- Additives -- Site of Injection -- Pregnancy -- Toxicity of Local Anesthetics -- Chemical Structure of Local Anesthetics and Classification of Local Anesthetics -- Ester-Linked Local Anesthetics -- Amide-Linked Local Anesthetics -- Lidocaine -- Mepivacaine -- Ropivacaine -- Bupivacaine -- References -- Chapter 13 Anticholinergics -- Introduction -- Mechanism of Action -- Chemical Structure and Pharmacokinetics -- Atropine -- Glycopyrrolate -- Pharmacodynamics -- Use with Other Drugs -- References -- Chapter 14 CNS Stimulants -- Introduction -- Doxapram -- Metabolism -- Clinical Use -- Methylxanthines -- References -- Chapter 15 Centrally Acting Muscle Relaxants -- Introduction and Physiology -- Guaifenesin -- Benzodiazepines -- Pharmacokinetics - Human -- Metabolism - Humans -- Dog Metabolism -- Diazepam -- Cats -- Diazepam -- Horses - Midazolam -- Alpacas - Midazolam -- Pharmacodynamics -- Reproductive/Nursing Safety -- Drug Interactions -- Veterinary Medicine - Uses and Specific Agents -- Midazolam -- Dosages and Usage -- Dogs -- Cats -- Horses -- Sedation in Neonatal Foals -- Camelids -- Small Ruminants -- Diazepam -- Flumazenil -- References."]
[{"$nulls":4},"Chapter 16 Neuromuscular Blocking Agents -- Introduction -- General Concepts and Nomenclature Regarding NMBAs -- Monitoring of Neuromuscular Function -- Depolarizing Neuromuscular Blocking Agents -- Effects on Organ Systems -- Non-depolarizing Neuromuscular Blocking Agents -- Benzylisoquinolines -- Aminosteroids -- Novel Non-depolarizing NMBAs -- References -- Chapter 17 Anticholinesterase Drugs and Reversal of Neuromuscular Blockade -- Introduction -- References -- Chapter 18 Sympathomimetics and Vasopressin -- Introduction -- Mechanism of Action and Main Effects -- Catecholamines - Structure and Pharmacokinetics -- Endogenous Catecholamines -- Epinephrine (Adrenaline) -- Cardiovascular Effects -- During CPR -- Other Effects -- Norepinephrine (Noradrenaline) -- Pharmacodynamics -- Other Effects -- Dopamine -- Pharmacodynamics -- Other Effects -- Synthetic Catecholamines -- Isoproterenol (Isoprenaline) -- Pharmacodynamics -- Dobutamine -- Pharmacodynamics -- Synthetic Non-catecholamines -- Phenylephrine (m-Synephrine, Neosynephrine) -- Pharmacodynamics -- Ephedrine -- Vasopressin (Arginine Vasopressin, Anti-Diuretic Hormone) -- Use in CPR -- Use in Septic Shock -- Selective Beta2 Adrenoceptor Agonists -- Albuterol "]
[{"$nulls":4},"(Salbutamol) -- Terbutaline -- Drug Interactions -- References -- Chapter 19 Antihypertensives -- Introduction -- Sympatholytic Drugs -- Selective α1-Adrenergic Receptor Antagonists -- Prazosin -- Terazosin and Doxazosin -- Non-Selective α1- and α2-Adrenergic Receptor Antagonists -- Phenoxybenzamine -- Phentolamine -- α2-Adrenergic Receptor Agonists -- Angiotensin Converting Enzyme (ACE) Inhibitors -- Benazepril -- Enalapril -- Angiotensin II Receptor Blockers -- Telmisartan -- Losartan -- Calcium Channel Blocker -- Amlodipine -- β-Adrenergic Receptor Blockers -- Vasodilators -- Others -- Acepromazine -- Magnesium Sulfate -- Diuretics."]
[{"$nulls":4},"References."]
[null,null,null,"Sommario/riassunto","\"In Pharmacology in Veterinary Anesthesia and Analgesia, a team of distinguished veterinary practitioners delivers a singular and comprehensive text dedicated to anesthetic drug pharmacology and drug interactions related specifically to anesthetic drugs in a veterinary setting. This concise, easily navigable reference combines information scattered throughout the academic literature and covers mechanisms of action of commonly used drugs in commonly encountered species, drug interactions, and clinical uses of anesthetic drugs. The volume explores drug metabolism, the effects of various drugs on organ systems, risks of adverse effects, as well as the impact of anesthesia on drugs, and the effects of drugs on anesthesia. Perfect for veterinary anesthesiologists and criticalists, internists, and surgeons, Pharmacology in Veterinary Anesthesia and Analgesia will also earn a place in the libraries of private practitioners performing anesthesia and veterinary technicians performing anesthesia, as well as researchers using veterinary species as a model\"--"]