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[null,"1.","Record Nr.",null,"UNINA9911019963403321"]
[null,null,"Titolo",null,"Fragment-based drug discovery : a practical approach / / editors, Edward R. Zartler, Michael J. Shapiro"]
[null,null,"Pubbl/distr/stampa",null,"Chichester, U.K., : John Wiley & Sons, 2008"]
[null,null,"ISBN",null,"9786612342752"]
[{"$nulls":4},"9781282342750"]
[{"$nulls":4},"1282342754"]
[{"$nulls":4},"9780470721551"]
[{"$nulls":4},"0470721553"]
[{"$nulls":4},"9780470721568"]
[{"$nulls":4},"0470721561"]
[null,null,"Descrizione fisica",null,"1 online resource (297 p.)"]
[null,null,"Disciplina",null,"615/.19"]
[null,null,"Soggetti",null,"Drug development"]
[{"$nulls":4},"Drugs - Design"]
[{"$nulls":4},"Ligands (Biochemistry)"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references and index."]
[null,null,"Nota di contenuto",null,"Fragment-Based Drug Discovery; Contents; List of Contributors; 1 Introduction to Fragment-based Drug Discovery; 2 Designing a Fragment Process to Fit Your Needs; 3 Assembling a Fragment Library; 4 Practical Aspects of Using NMR in Fragment-based Screening; 5 Application of Protein-Ligand NOE Matching to the Rapid Evaluation of Fragment Binding Poses; 6 Target-immobilized NMR Screening: Validation and Extension to Membrane Proteins; 7 In Situ Fragment-based Medicinal Chemistry: Screening by Mass Spectrometry; 8 Computational Approaches to Fragment and Substructure Discovery and Evaluation"]
[{"$nulls":4},"9 Virtual Fragment Scanning: Current Trends, Applications and Web-based Tools10 Capture Methods for Fragment-based Discovery; 11 Identification of High-affinity -Secretase Inhibitors Using Fragment-based Lead Generation; Index"]
[null,null,null,"Sommario/riassunto","Fragment-based drug discovery (FBDD) is a new paradigm in drug discovery that utilizes very small molecules - fragments of larger molecules. It is a faster, cheaper, smarter way to do drug discovery, as "]
[{"$nulls":4},"shown by the number of pharmaceutical companies that have embraced this approach and the biotechnology companies who use fragments as their sole source of drug discovery.  Fragment-Based Drug Discovery: A Practical Approach is a guide to the techniques and practice of using fragments in drug screening. The emphasis is on practical guidance, with procedures, case studies, practical ti"]