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[null,"1.","Record Nr.",null,"UNINA9910729795003321"]
[null,null,"Autore",null,"Casamassimi Amelia"]
[null,null,"Titolo",null,"Transcriptional Regulation and Its Misregulation in Human Diseases / / Amelia Casamassimi, Alfredo Ciccodicola, Monica Rienzo"]
[null,null,"Pubbl/distr/stampa",null,"Basel : , : MDPI - Multidisciplinary Digital Publishing Institute, , 2023"]
[null,null,"Descrizione fisica",null,"1 online resource (308 pages)"]
[null,null,"Disciplina",null,"572.865"]
[null,null,"Soggetti",null,"Genetic regulation"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Sommario/riassunto","Transcriptional regulation is a critical biological process that allows the cell or an organism to respond to a variety of intra- and extracellular signals, to define cell identity during development, to maintain it throughout its lifetime, and to coordinate cellular activity. This control involves multiple temporal and functional steps as well as innumerable molecules including transcription factors, cofactors, and chromatin regulators. It is well known that many human disorders are characterized by global transcriptional dysregulation because most of the signaling pathways ultimately target transcription machinery. Indeed, many syndromes and genetic and complex diseases--cancer, autoimmunity, neurological and developmental disorders, and metabolic and cardiovascular diseases--can be caused by mutations/alterations in regulatory sequences, transcription factors, splicing regulators, cofactors, chromatin regulators, ncRNAs, and other components of transcription apparatus. It is worth noting that advances in our understanding of molecules and mechanisms involved in the transcriptional circuitry and apparatus lead to new insights into the pathogenetic mechanisms of various human diseases and disorders. Thus, this Special Issue is focused on molecular genetics and genomics studies exploring the effects of transcriptional misregulation on human diseases."]
[null,"2.","Record Nr.",null,"UNINA9910988181903321"]
[null,null,"Autore",null,"Ignacio Ferreras"]
[null,null,"Titolo",null,"Fundamentals of Dark Matter"]
[null,null,"Pubbl/distr/stampa",null,"UCL Press, 2025"]
[null,null,"ISBN",null,"9781800084704"]
[{"$nulls":4},"1800084706"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,"3.","Record Nr.",null,"UNINA9911019849003321"]
[null,null,"Autore",null,"Kothari Vinod"]
[null,null,"Titolo",null,"Credit derivatives and structured credit trading / / Vinod Kothari"]
[null,null,"Pubbl/distr/stampa",null,"Singapore, : John Wiley & Sons (Asia), 2009"]
[null,null,"ISBN",null,"9786613619075"]
[{"$nulls":4},"9781118178782"]
[{"$nulls":4},"1118178785"]
[{"$nulls":4},"9781280589249"]
[{"$nulls":4},"1280589248"]
[{"$nulls":4},"9781118390412"]
[{"$nulls":4},"1118390415"]
[{"$nulls":4},"9781118178805"]
[{"$nulls":4},"1118178807"]
[null,null,"Edizione",null,"[Rev. ed.]"]
[null,null,"Descrizione fisica",null,"1 online resource (512 p.)"]
[null,null,"Collana",null,"Wiley finance"]
[null,null,"Disciplina",null,"332.6457"]
[null,null,"Soggetti",null,"Credit derivatives"]
[{"$nulls":4},"Credit - Management"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references and index."]
[null,null,"Nota di contenuto",null,"pt. 1. Market, instruments and motivations -- pt. 2. Single-name insrtuments [instruments] -- pt. 3. Portfolio products -- pt. 4. Pricing and valuation of credit derivatives -- pt. 5. Legal, regulatory, operational, tax and accounting aspects."]
[null,null,null,"Sommario/riassunto","Credit derivatives as a financial tool has been growing exponentially from almost nothing more than seven years ago to approximately US5 trillion deals completed by end of 2005. This indicates the growing importance of credit derivatives in the financial sector and how widely it is being used these days by banks globally. It is also being increasingly used as a device of synthetic securitisation. This significant market trend underscores the need for a book of such a nature.Kothari, an undisputed expert in credit derivatives, explains the subject matter using easy-to-understand terms, pre"]