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[null,"1.","Record Nr.",null,"UNINA9911018923203321"]
[null,null,"Titolo",null,"Genetic effects on environmental vulnerability to disease / / edited by Michael Rutter"]
[null,null,"Pubbl/distr/stampa",null,"Chicester, : Wiley-Blackwell (an imprint of John Wiley & Sons Ltd), 2008"]
[null,null,"ISBN",null,"9786611840488"]
[{"$nulls":4},"9781281840486"]
[{"$nulls":4},"1281840483"]
[{"$nulls":4},"9780470696781"]
[{"$nulls":4},"0470696788"]
[{"$nulls":4},"9780470696798"]
[{"$nulls":4},"0470696796"]
[null,null,"Descrizione fisica",null,"1 online resource (237 p.)"]
[null,null,"Collana",null,"Novartis Foundation symposium ; ; 293"]
[null,null,"Disciplina",null,"616.042"]
[null,null,"Soggetti",null,"Disease susceptibility - Genetic aspects"]
[{"$nulls":4},"Environmentally induced diseases - Genetic aspects"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references and indexes."]
[null,null,"Nota di contenuto",null,"Genetic effects on environmental vulnerability to disease; Contents; 1: Introduction: whither gene-environment interactions?; 2: Gene-environment interaction: overcoming methodological challenges; 3: Gene-environment interaction and behavioral disorders: a developmental perspective based on endophenotypes; 4: Use of monozygotic twins to investigate the relationship between 5HTTLPR genotype, depression and stressful life events: an application of Item Response Theory; GENERAL DISCUSSION I; 5: Role of gene-stress interactions in gene-finding studies"]
[{"$nulls":4},"6: Practice and public policy in the era of gene-environment interactions7: Gene-environment interaction and the metabolic syndrome; GENERAL DISCUSSION II; 8: Longitudinal studies of gene-environment interaction in common diseases-good value for money?; 9: Gene-environment interactions in breast cancer; 10: Unbiased forward genetics and systems biology approaches to understanding how gene-environment interactions work to predict susceptibility and outcomes of infections; 11: Gene-environment interactions in environmental lung diseases; GENERAL DISCUSSION III"]
[{"$nulls":4},"12: Gene-environment interaction in complex diseases: asthma as an "]
[{"$nulls":4},"illustrative case13: Conclusions: taking stock and looking ahead; Glossary; Contributor Index; Subject Index; Color Plate"]
[null,null,null,"Sommario/riassunto","Much research has attempted to show direct linear relations between genes and disorder. However, scientists have been discouraged by inconsistent findings based on this simple gene-phenotype approach. The alternative approach is to incorporate information about the environment. A gene-environment interaction approach assumes that environmental pathogens cause disorder, whereas genes influence susceptibility to environmental pathogens.  This book brings together contributions from experts from multiple disciplines who discuss:How epidemiological cohort studies can bett"]