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[null,"1.","Record Nr.",null,"UNINA9911006576303321"]
[null,null,"Titolo",null,"Evaluation of the linear-nonthreshold dose-response model for ionizing radiation"]
[null,null,"Pubbl/distr/stampa",null,"Bethesda, Md., : National Council on Radiation Protection and Measurements, c2001"]
[null,null,"ISBN",null,"978-0-929600-69-7"]
[{"$nulls":4},"978-1-60119-472-5"]
[{"$nulls":4},"0-929600-69-X"]
[null,null,"Descrizione fisica",null,"1 online resource (296 p.)"]
[null,null,"Collana",null,"NCRP report ; ; no. 136"]
[null,null,"Disciplina",null,"612/.01448"]
[null,null,"Soggetti",null,"Radiation - Toxicology"]
[{"$nulls":4},"Low-level radiation - Dose-response relationship"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","\"Issued June 4, 2001.\""]
[{"$nulls":4},"\"Recommendations of the National Council on Radiation Protection and Measurements.\""]
[null,null,null,"Nota di bibliografia","Includes bibliographical references (p. 212-263) and index."]
[null,null,"Nota di contenuto",null,"\"\"Cover Page\"\"; \"\"Preface\"\"; \"\"Contents\"\"; \"\"1. Executive Summary\"\"; \"\"2. Introduction\"\"; \"\"3. Biophysical\"\"; \"\"3.1 Energy Deposition and Its Relevance to Questions of Low-Dose Response\"\"; \"\"3.1.1 Track Structure\"\"; \"\"3.1.2 Quantitative Characterization of Energy Deposition in Small Sites\"\"; \"\"3.1.3 Definition of Low Dose, Corresponding to an Average of One Energy Deposition Event per Target\"\"; \"\"3.2 Implications of Energy-Deposition Patterns for Independent Cellular Effects at Low Doses\"\"; \"\"3.3 Implications of Energy-Deposition Patterns for Carcinogenic Effects of Radiation\"\""]
[{"$nulls":4},"\"\"3.3.1 Evidence Regarding the Clonality of Tumors\"\"\"\"3.3.2 Relationship Between Initially-Damaged Cells and Tumorigenic Cells\"\"; \"\"3.4 Conclusions\"\"; \"\"3.5 Research Needs\"\"; \"\"4. Deoxyribonucleic Acid Repair and Processing after Low Doses and Low-Dose Rates of Ionizing Radiation\"\"; \"\"4.1 Ionizing Radiation-Induced DNA Lesions and Their Repair\"\"; \"\"4.1.1 Single-Strand Breaks (Including Deoxyribose Damage)\"\"; \"\"4.1.2 Base Damage and Loss\"\"; \"\"4.1.3 DNA-Protein Cross-Links\"\"; \"\"4.1.4 Double-Strand Breaks\"\"; \"\"4.1.5 Multiply-Damaged Sites\"\"; \"\"4.1.6 Mismatch Repair\"\""]
[{"$nulls":4},"\"\"4.1.7 Effects of Linear-Energy Transfer\"\"\"\"4.1.8 Spontaneous DNA Damage\"\"; \"\"4.2 Cell-Cycle Checkpoints\"\"; \"\"4.3 Programmed Cell Death (Apoptosis)\"\"; \"\"4.4 Impact of Cell-Cycle Checkpoints and Apoptosis on "]
[{"$nulls":4},"the Dose Response for DNA Repair at Low-Dose Rates\"\"; \"\"4.5 The Adaptive Response\"\"; \"\"4.6 Summary\"\"; \"\"4.7 Research Needs\"\"; \"\"5. Mutagenesis\"\"; \"\"5.1 Introduction\"\"; \"\"5.2 Potential Mechanisms of Mutagenesis\"\"; \"\"5.2.1 Replication Errors\"\"; \"\"5.2.2 Mutations Arising During Repair\"\"; \"\"5.3 Dose-Response Studies with Low Linear-Energy Transfer Radiation\"\"; \"\"5.3.1 Human in Vivo\"\""]
[{"$nulls":4},"\"\"5.3.2 Animal in Vivo\"\"\"\"5.3.3 Mammalian Cells in Vitro\"\"; \"\"5.4 Dose-Response Studies with High Linear-Energy Transfer Radiation\"\"; \"\"5.5 Summary\"\"; \"\"5.6 Research Needs\"\"; \"\"6. Chromosome Aberrations Induced by Low Doses and Low-Dose Rates of Ionizing Radiation\"\"; \"\"6.1 Misrepair, Misreplication, and Chromosome Aberration Formation\"\"; \"\"6.1.1 Chromosome-Type Aberrations\"\"; \"\"6.1.2 Chromatid-Type Aberrations\"\"; \"\"6.1.3 Mechanisms of Formation of Chromosome Aberrations\"\"; \"\"6.1.4 Dose-Response Curves: Acute and Chronic Exposures\"\"; \"\"6.2 Distribution of Aberrations Within and Among Cells\"\""]
[{"$nulls":4},"\"\"6.2.1 Intercellular Distributions of Chromosome Aberrations\"\"\"\"6.2.2 Inter- and Intrachromosomal Distribution of Chromosome Aberrations\"\"; \"\"6.3 Uncertainties in Shapes of Dose-Response Curves at Low Doses\"\"; \"\"6.3.1 Nonlinear and Threshold Responses\"\"; \"\"6.3.2 Effect of Adaptive Response\"\"; \"\"6.3.3 Efficiency of DNA Repair\"\"; \"\"6.3.4 Inducibility of DNA Repair and Cell-Cycle Checkpoints\"\"; \"\"6.3.5 Genomic Instability\"\"; \"\"6.4 Association Between Chromosomal Changes and Cancer\"\"; \"\"6.5 Biological Dosimetry for Chromosome Aberrations\"\"; \"\"6.5.1 Acute Exposures\"\"; \"\"6.5.2 Chronic Exposures\"\""]
[{"$nulls":4},"\"\"6.5.3 Evidence for Threshold and/or Linearity in Dose Response\"\""]