{"text_format":"2","workbook":"xls","n_sheets":1,"sheets":["report2"],"not_rendered":{"charts":0,"images":0,"macros":0,"external_links":1,"defined_names":1,"comments":0,"pivot_tables":0},"unopened":[],"bounds":{"document_bytes":16777216,"sheet_cells":100000,"run_cost":"one","rows_first":2000,"rows_last":500,"rows_between":2000,"halvings":0,"cell_chars":16384,"cell_head_chars":4096},"cells_cut":0,"cells_raw":0,"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"report2","index":0,"n_rows":25,"n_cols":5,"rows_kept":25,"cut":false,"hidden":false,"merged":[[0,2,0,3],[0,4,0,5],[1,2,1,3],[1,4,1,5],[2,2,2,3],[2,4,2,5],[3,2,3,3],[5,2,5,3],[9,2,9,3],[10,2,10,3],[11,2,11,3],[12,2,12,3],[13,2,13,3],[16,2,16,3],[17,2,17,3],[19,2,19,3]],"flags":["formulas_cached_only"]}
[null,"1.","Record Nr.",null,"UNINA9911006524503321"]
[null,null,"Autore",null,"Kulkarni Vitthal S"]
[null,null,"Titolo",null,"Handbook of non-invasive drug delivery systems : science and technology / / Vitthal S. Kulkarni"]
[null,null,"Pubbl/distr/stampa",null,"Norwich, N.Y., : William Andrew"]
[{"$nulls":4},"Oxford, : Elsevier Science [distributor], 2009"]
[null,null,"ISBN",null,"1-282-48172-X"]
[{"$nulls":4},"9786612481727"]
[{"$nulls":4},"0-8155-2026-3"]
[{"$nulls":4},"0-08-095187-2"]
[null,null,"Edizione",null,"[1st ed.]"]
[null,null,"Descrizione fisica",null,"1 online resource (327 pages)"]
[null,null,"Collana",null,"Personal Care and Cosmetic Technology"]
[null,null,"Disciplina",null,"615.6"]
[null,null,"Soggetti",null,"Drug delivery systems"]
[{"$nulls":4},"Transdermal medication"]
[{"$nulls":4},"Oral medication"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,"Nota di contenuto",null,"Front Cover; Handbook of NON-INVASIVE DRUG DELIVERY SYSTEMS; Copyright; CONTENTS; PREFACE; EDITOR BIOGRAPHY; CONTRIBUTORS; ACKNOWLEDGEMENT; CHAPTER 1Topical and Transdermal Drug Delivery; 1.1 STRUCTURE OF THE SKIN; 1.2 TOPICAL vs. TRANSDERMAL DRUG DELIVERY; 1.3 PERCUTANEOUS ABSORPTION PATHWAYS; 1.4 APPROACHES TO ENHANCE PASSIVE CUTANEOUSDRUG ABSORPTION; 1.5 CONCLUSIONS; REFERENCES; CHAPTER 2 Micellar Nanoparticles: Applications for Topical and Passive Transdermal Drug Delivery; 2.1 INTRODUCTION; 2.2 TRANSDERMAL DRUG DELIVERY APPLICATIONS OF MNPTECHNOLOGY"]
[{"$nulls":4},"2.3 TOPICAL DRUG DELIVERY APPLICATIONS OF MNPTECHNOLOGY; 2.4 CONCLUSION; REFERENCES; CHAPTER 3Emulsions and Microemulsions for Topical and Transdermal Drug Delivery; 3.1 OVERVIEW OF BASIC ASPECTS OF EMULSIONSAND MICROEMULSIONS; 3.2 APPLICATION OF EMULSIONS FOR TOPICALAND TRANSDERMAL DRUG DELIVERY; 3.3 ADVANCES IN USING MICROEMULSIONS AS TOPICALAND TRANSDERMAL DRUG DELIVERY SYSTEMS; REFERENCES; CHAPTER 4Iontophoretic Transdermal Drug Delivery; 4.1 INTRODUCTION; 4.2 HISTORY AND DEVELOPMENT OF IONTOPHORESIS; 4.3 ADVANTAGES AND LIMITATIONS OF IONTOPHORESIS"]
[{"$nulls":4},"4.4 IONTOPHORETIC DELIVERY PRINCIPLES AND SYSTEM COMPONENTS; 4.5 DRUG TRANSPORT IN IONTOPHORESIS; 4.6 PATHWAYS FOR IONTOPHORETIC TRANSPORTAND FACTORS AFFECTING THE SAME; 4.7 PROPERTIES OF THE DRUG/ION: CONCENTRATION,COMPETING IONS, AND MOLECULAR SIZE; 4.8 PROPERTIES OF THE IONTOPHORETIC SYSTEM: pH, CURRENT; 4.9 COMBINATION STRATEGIES TO IMPROVETRANSDERMAL IONTOPHORETIC DRUG DELIVERY; 4.10 REVERSE IONTOPHORESIS; 4.11 APPLICATIONS OF IONTOPHORESIS; 4.12 CURRENT AND FUTURE DEVELOPMENT; REFERENCES; CHAPTER 5 Ultrasound-based Technology for Skin Barrier Permeabilization; 5.1 INTRODUCTION"]
[{"$nulls":4},"5.2 WHAT IS ULTRASOUND?; 5.3 ULTRASOUND BIOEFFECTS; 5.4 HISTORICAL BACKGROUND; 5.5 SONOPHORESIS FOR ENHANCED DRUG DELIVERY; 5.6 ONGOING DEVELOPMENTS; 5.7 CURRENT CHALLENGES AND TRENDS; REFERENCES; CHAPTER 6Microneedles - Minimally Invasive Transdermal Delivery Technology; 6.1 INTRODUCTION; 6.2 MICRONEEDLE GEOMETRY; 6.3 TYPES OF APPROACH; 6.4 FACTORS INFLUENCING TRANSDERMAL PERMEATION; 6.5 MICRONEEDLE TECHNOLOGY IN DRUG DELIVERY; 6.6 COMMERCIALIZATION OF MICRONEEDLE TECHNOLOGY; 6.7 CONCLUSION; REFERENCES; CHAPTER 7 Recent Advances in Ophthalmic Drug Delivery; 7.1 INTRODUCTION"]
[{"$nulls":4},"7.2 THE ANATOMY OF THE EYE; 7.3 DELIVERY SYSTEMS FOR THE ANTERIOR SEGMENT; 7.4 RETINAL DRUG DELIVERY SYSTEMS; 7.5 CONCLUSIONS; REFERENCES; CHAPTER 8 Nasal Delivery of Micro- and Nano-encapsulated Drugs; 8.1 INTRODUCTION; 8.2 PHYSIOLOGY OF THE NOSE; 8.3 DRUG DELIVERY FORMULATION; 8.4 MICRO- AND NANO-ENCAPSULATION; 8.5 SUMMARY; REFERENCES; CHAPTER 9 Pulmonary Drug Delivery; 9.1 GENERAL INTRODUCTION; 9.2 PULMONARY DRUG DEPOSITION MECHANISMS; 9.3 PULMONARY DRUG DELIVERY METHODS; 9.4 ANALYTICAL METHODS; 9.5 CHALLENGES AND ADVANTAGES; 9.6 CONCLUSIONS; REFERENCES; CHAPTER 10 Regulatory Aspects of Nasal and Pulmonary Spray Drug; nbsp; Products"]
[null,null,null,"Sommario/riassunto","With the improvements in formulation science and certain transdermal delivery technologies, the non-invasive mode of drug delivery is now ready to compete with traditional methods of oral and injectible routes of drug delivery. The Handbook of Non-Invasive Drug Delivery Systems encompasses the broad field of non-invasive drug delivery systems that include drug delivery via topical, transdermal-passive, transdermal-active (device- aided enhanced penetration), trans-mucosal membrane, trans-ocular membrane as well as delivery via alveolar membrane from inhaled medication. Patient complianc"]