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[null,"1.","Record Nr.",null,"UNINA9911004715503321"]
[null,null,"Titolo",null,"Extrapolation of radiation-induced cancer risks from nonhuman experimental systems to humans [[electronic resource]]"]
[null,null,"Pubbl/distr/stampa",null,"Bethesda, MD, : National Council on Radiation Protection and Measurements, c2005"]
[null,null,"ISBN",null,"1-4294-7996-5"]
[{"$nulls":4},"1-60119-213-4"]
[null,null,"Descrizione fisica",null,"1 online resource (280 p.)"]
[null,null,"Collana",null,"NCRP report ; ; no. 150"]
[null,null,"Disciplina",null,"616.99/4071"]
[null,null,"Soggetti",null,"Radiation carcinogenesis"]
[{"$nulls":4},"Radiation - Toxicology"]
[{"$nulls":4},"Animal models in research"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","\"Recommendations of the National Council on Radiation Protection and Measurements.\""]
[{"$nulls":4},"\"Issued November 18, 2005.\""]
[null,null,null,"Nota di bibliografia","Includes bibliographical references (p. 194-241) and index."]
[null,null,"Nota di contenuto",null,"\"\"Cover\"\"; \"\"Preface\"\"; \"\"Contents\"\"; \"\"1. Executive Summary and Recommendations\"\"; \"\"1.1 Why Is Extrapolation Still Required?\"\"; \"\"1.2 Summary of Findings\"\"; \"\"1.2.1 Historical Aspects\"\"; \"\"1.2.2 Neoplastic Disease\"\"; \"\"1.2.3 Somatic Genetic Damage at Molecular and Cellular Levels\"\"; \"\"1.2.4 Extrapolation Models and Methods\"\"; \"\"1.3 Conclusions\"\"; \"\"1.4 Recommendations\"\"; \"\"2. Introduction\"\"; \"\"3. History of Extrapolation: Nonhuman Experimental Systems to Humans\"\"; \"\"3.1 Introduction\"\"; \"\"3.2 Lessons Learned from Genetic Risks\"\"; \"\"3.2.1 Methods of Estimation\"\""]
[{"$nulls":4},"\"\"3.2.2 Discussion of Methods of Estimating Genetic Risk\"\"\"\"3.2.3 Role of Genetics in the Estimation of Somatic Risks\"\"; \"\"3.3 Somatic Risks\"\"; \"\"4. Tissue and Organ Differences Among Species with Emphasis on the Cells of Origin of Cancers\"\"; \"\"4.1 Introduction\"\"; \"\"4.2 Hematopoietic System\"\"; \"\"4.2.1 Introduction: Leukemias and Lymphomas\"\"; \"\"4.2.2 Comparison of Radiation-Induced Leukemias Among Species\"\"; \"\"4.2.3 Pathology and Dose-Response Relationships\"\"; \"\"4.2.4 Comparison of Hematopoietic Systems\"\"; \"\"4.2.5 Target Cells\"\""]
[{"$nulls":4},"\"\"4.2.6 Comparison of Cytogenetic Processes: Common or Species-Specific Patterns\"\"\"\"4.2.7 Leukemogenesis Resulting from Gene Rearrangements\"\"; \"\"4.2.8 Secondary Cytogenetic Lesions Associated with Leukemia Promotion and Progression\"\"; \"\"4.2.9 Hematopoietic Cell "]
[{"$nulls":4},"Origins of the Putative â€œCriticalâ€? Genic Lesions and the Nature of Induced Genic Dysfunctions\"\"; \"\"4.2.10 Cooperating Oncogenes in Lymphoid Neoplasias\"\"; \"\"4.2.11 Cooperating Oncogenes in Myeloid Neoplasias\"\"; \"\"4.2.12 Hematopoeitic Microenvironment\"\"; \"\"4.2.13 Summary\"\"; \"\"4.3 Lung\"\"; \"\"4.3.1 Introduction\"\""]
[{"$nulls":4},"\"\"4.3.2 Adenocarcinoma\"\"\"\"4.3.3 Squamous-Cell Carcinoma\"\"; \"\"4.3.4 Small-Cell Lung Carcinoma\"\"; \"\"4.3.5 Large-Cell Carcinoma\"\"; \"\"4.3.6 Summary\"\"; \"\"4.4 Breast\"\"; \"\"4.4.1 Histogenesis of Mammary Glands and Mammary Cancer\"\"; \"\"4.4.2 Hormones and Mammary Carcinogenesis\"\"; \"\"4.4.3 Cellular Origins of Mammary Cancer\"\"; \"\"4.4.4 Summary\"\"; \"\"4.5 Thyroid\"\"; \"\"4.5.1 General Background\"\"; \"\"4.5.2 Histogenesis of the Thyroid Gland and Thyroid Cancer\"\"; \"\"4.5.3 Thyroid Function and its Control\"\"; \"\"4.5.4 Cellular Economy of the Thyroid Gland and the Origin of Cancer\"\"; \"\"4.5.5 Summary\"\"; \"\"4.6 Skin\"\""]
[{"$nulls":4},"\"\"4.6.1 Introduction\"\"\"\"4.6.2 Epidermal Cancers\"\"; \"\"4.6.3 Melanoma\"\"; \"\"4.6.4 Tumors of the Dermis\"\"; \"\"4.6.5 Mechanisms of Epidermal Carcinogenesis\"\"; \"\"4.6.6 Importance of Interactions\"\"; \"\"4.6.7 Summary\"\"; \"\"4.7 Gastrointestinal Tract\"\"; \"\"4.7.1 Introduction\"\"; \"\"4.7.2 Stomach\"\"; \"\"4.7.3 Small Intestine\"\"; \"\"4.7.4 Colorectal Tumors\"\"; \"\"4.7.5 Summary\"\"; \"\"4.8 Bone\"\"; \"\"4.8.1 Humans\"\"; \"\"4.8.2 Mice\"\"; \"\"4.8.3 Rats\"\"; \"\"4.8.4 Dogs\"\"; \"\"4.8.5 Summary\"\"; \"\"5. Radiation Effects at the Molecular and Cellular Levels\"\"; \"\"5.1 Introduction\"\""]
[{"$nulls":4},"\"\"5.2 Effects of Ionizing Radiations at the Molecular Level\"\""]