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[null,"1.","Record Nr.",null,"UNINA990006485310403321"]
[null,null,"Autore",null,"Levefer, Ernest W."]
[null,null,"Titolo",null,"Crisis in the Congo : A United Nations Force in Action / Ernest W. Levefer"]
[null,null,"Pubbl/distr/stampa",null,"Washington : The Brookings Institution, 1965"]
[null,null,"Descrizione fisica",null,"XII, 215 p. ; 22 cm"]
[null,null,"Disciplina",null,"967.5"]
[null,null,"Locazione",null,"FSPBC"]
[null,null,"Collocazione",null,"XIV E 1171"]
[null,null,"Lingua di pubblicazione",null,"Italiano"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,"2.","Record Nr.",null,"UNINA9910887362803321"]
[null,null,"Titolo",null,"Dieci lezioni sulle vitamine / raccolte dall'Istituto biochimico italiano"]
[null,null,"Pubbl/distr/stampa",null,"[Milano, : Istituto biochimico italiano]"]
[null,null,"Descrizione fisica",null,"v. ; 18 cm"]
[null,null,"Disciplina",null,"615.328"]
[null,null,"Locazione",null,"FAGBC"]
[null,null,"Collocazione",null,"A AGR 1244-1"]
[{"$nulls":4},"A AGR 1244-2"]
[{"$nulls":4},"A AGR 1244-3"]
[{"$nulls":4},"A AGR 1244-4"]
[{"$nulls":4},"A AGR 1244-5"]
[{"$nulls":4},"A AGR 1244-6"]
[{"$nulls":4},"A AGR 1244-7"]
[{"$nulls":4},"A AGR 1244-8"]
[{"$nulls":4},"A AGR 1244-9"]
[{"$nulls":4},"A AGR 1244-10"]
[null,null,"Lingua di pubblicazione",null,"Italiano"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Titolo desunto dal contenitore"]
[null,null,"Nota di contenuto",null,"1.: Indirizzi di realizzazione nel campo della vitaminologia 2.: Le vitamine nel campo ostetrico 3.: Disfunzioni vitaminiche nella patogenesi del rachitismo 4.: Le vitamine nello sviluppo del lattante 5.: Vitamine e funzioni endocrine 6.: Rapporti delle vitamine con la patologia del sistema nervoso 7.: Fisiopatologia della digestione e vitamine 8.: Discrasie ematiche di genesi avitaminica 9.: Vitamine e resistenza immunitaria, con speciale riguardo alla tubercolosi 10.: Rapporti tra vitamine e apparato dentario"]
[null,"3.","Record Nr.",null,"UNINA9910983338303321"]
[null,null,"Autore",null,"Aoki Keisuke"]
[null,null,"Titolo",null,"Development of Mirror-Image VHHs with Less Immunogenicity / / by Keisuke Aoki"]
[null,null,"Pubbl/distr/stampa",null,"Singapore : , : Springer Nature Singapore : , : Imprint : Springer, , 2025"]
[null,null,"ISBN",null,"9789819613014"]
[{"$nulls":4},"9819613019"]
[null,null,"Edizione",null,"[1st ed. 2025.]"]
[null,null,"Descrizione fisica",null,"1 online resource (140 pages)"]
[null,null,"Collana",null,"Springer Theses, Recognizing Outstanding Ph.D. Research, , 2190-5061"]
[null,null,"Disciplina",null,"541.39"]
[null,null,"Soggetti",null,"Chemistry"]
[{"$nulls":4},"Pharmacy"]
[{"$nulls":4},"Proteins"]
[{"$nulls":4},"Immunogenetics"]
[{"$nulls":4},"Chemical Synthesis"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,"Nota di contenuto",null,"Chapter 1.Introduction -- Chapter 2.Chemical Synthesis of Mirror-Image VHHs and Evaluation of Their Immunogenicity -- Chapter 3.Identification of a Mirror-Image VHH against Vascular Endothelial Growth Factor -- Chapter 4.Synthetic Study of Full-Length Hepatitis B Virus Core Protein and Its Capsid Assembly -- Chapter 5.Chemical Synthesis of Interleukin-6 for Mirror-Image VHH Discovery -- Chapter 6.Conclusions."]
[null,null,null,"Sommario/riassunto","This book outlines the chemical synthesis of therapeutic targets and a screening process for unexplored mirror-image single-domain antibodies (D-VHH). This book first describes the chemical synthesis of model VHH and the characteristics of both enantiomeric VHHs, including binding activity, biodistribution and immunogenicity. Immunogenicity testing in mice demonstrated that administration of conventional L-VHH induced the generation of anti-drug antibodies while D-VHH-binding antibodies were not observed in D-VHH-immunized mice. Second, it is explained that the T7-phage-based mirror-image screening system was developed to identify D-VHH antibody fragments capable of binding to vascular endothelial growth factors. Additionally, this book details the chemical synthesis of full-length hepatitis B virus core protein and interleukin-6 for the "]
[{"$nulls":4},"application of exploring D-VHHs and other mirror-image molecules. Demonstrating that it is possible to develop a D-VHH that preferentially binds the native target protein and exhibits reduced immunogenicity, this book is useful for anyone interested in developing alternative biotherapeutics with reduced immunogenicity by combining chemical and biological approaches."]