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[null,"1.","Record Nr.",null,"UNINA9910974206303321"]
[null,null,"Titolo",null,"Genome instability and transgenerational effects / / Igor Kovalchuk and Olga Kovalchuk, editors"]
[null,null,"Pubbl/distr/stampa",null,"New York, : Nova Science Publishers, c2010"]
[null,null,"ISBN",null,"1-61761-663-X"]
[null,null,"Edizione",null,"[1st ed.]"]
[null,null,"Descrizione fisica",null,"1 online resource (490 p.)"]
[null,null,"Collana",null,"Genetics--research and issues series"]
[null,null,"Disciplina",null,"572.8/77"]
[null,null,"Soggetti",null,"Epigenesis"]
[{"$nulls":4},"Mutation (Biology)"]
[{"$nulls":4},"Variation (Biology)"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references and index."]
[null,null,"Nota di contenuto",null,"\"\"GENOME INSTABILITY AND TRANSGENERATIONAL EFFECTS\"\"; \"\"GENOME INSTABILITY AND TRANSGENERATIONAL EFFECTS\"\"; \"\"CONTENTS \"\"; \"\"PREFACE \"\"; \"\"GENETIC AND EPIGENETIC REGULATION  OF TRANSGENERATIONAL CHANGES  IN GENOME STABILITY: AN OVERVIEW\"\"; \"\"REFERENCES \"\"; \"\"GENETIC AND EPIGENETIC MECHANISMS ENSURING STABILITY OF MAMMALIAN GENOMES\"\"; \"\"ABSTRACT \"\"; \"\"INTRODUCTION \"\"; \"\"GENETIC MECHANISMS OF GENOME STABILITY \"\"; \"\"Direct Reversal of Damage \"\"; \"\"Base Excision Repair \"\"; \"\"Nucleotide Excision Repair \"\"; \"\"Mismatch Repair \"\"; \"\"Repair of DNA Strand Breaks by Homologous Recombination \"\""]
[{"$nulls":4},"\"\"Non-Homologous End Joining \"\"\"\"Cell Cycle Checkpoints \"\"; \"\"EPIGENETIC REGULATION OF GENOMIC STABILITY \"\"; \"\"DNA Methylation \"\"; \"\"Histone Modifications \"\"; \"\"Short RNA-Mediated Silencing \"\"; \"\"CONCLUSION \"\"; \"\"REFERENCES \"\"; \"\"GENETIC AND EPIGENETIC REGULATION  OF GENOME STABILITY IN PLANTS\"\"; \"\"ABSTRACT \"\"; \"\"INTRODUCTION \"\"; \"\"1. ENDOGENOUS AND EXOGENOUS FACTORS THAT AFFECT  GENOME STABILITY\"\"; \"\"1.1. Reactive Oxygen Species Challenge DNA the Repair Machinery  and Decrease Genome Stability \"\"; \"\"1.2. The Choice of DNA Repair Pathway May Regulate Plant Genome Stability \"\""]
[{"$nulls":4},"\"\"1.3. The Importance of Plant Genome Plasticity for Stress Tolerance and Genome Evolution\"\"\"\"2. MECHANISMS AND FUNCTIONS OF EPIGENETIC REGULATIONS  IN THE PLANT GENOME \"\"; \"\"2.1. DNA Methylation Is a Critical Component in the System of Epigenetic Modifications in Plants\"\"; \"\"2.2. Histone Modifications and DNA "]
[{"$nulls":4},"Methylation Are Interdependent \"\"; \"\"2.3. Chromatin Remodeling Shapes Chromatin Structure and Complements DNA and Histone Modifications\"\"; \"\"3. EPIGENETIC MODIFICATIONS â€? A STRESS-RESPONSIVE MECHANISM CONTROLLING GENE REGULATION  AND GENOME STABILITY\"\""]
[{"$nulls":4},"\"\"3.1. Effects of Stress on Epigenetic Regulations \"\"\"\"3.2. Small RNAs May Direct Epigenetic Modifications to a Specific Genomic Locus\"\"; \"\"3.2.1. The Complexity and Functional Redundancy of smRNA Biogenesis Pathways in Arabidopsis \"\"; \"\"3.2.2. Mechanisms of smRNA-Directed Epigenetic Regulations \"\"; \"\"3.2.3. Small RNA Biogenesis is a Sensitive Stress-Responsive System \"\"; \"\"4. INDUCIBLE EPIGENETIC CHANGES MAY CHANGE GENOME STABILITY AND GUIDE GENOME EVOLUTION\"\"; \"\"CONCLUDING REMARKS \"\"; \"\"ACKNOWLEDGMENTS \"\"; \"\"REFERENCES \"\"; \"\"EVOLUTION OF THE FPG/NEI FAMILY OF DNA GLYCOSYLASES \"\""]
[{"$nulls":4},"\"\"ABSTRACT \"\"\"\"ABBREVIATIONS \"\"; \"\"INTRODUCTION \"\"; \"\"METHODS \"\"; \"\"EVENTS IN THE FPG/NEI PHYLOGENY \"\"; \"\"Horizontal Transfer \"\"; \"\"Changes in Substrate Specificity \"\"; \"\"Changes in the Structural Zinc-Finger Motif \"\"; \"\"Expansion within the Actinobacteria \"\"; \"\"THE ENZYMATIC FUNCTION OF THE FPG2 GLADE REMAINS UNKNOWN \"\"; \"\"CONCLUSION \"\"; \"\"REFERENCES \"\"; \"\"STRESS-INDUCED MUTAGENESIS IN BACTERIA \"\"; \"\"ABSTRACT \"\"; \"\"INTRODUCTION \"\"; \"\"STRESSFUL (MUTAGENIC) FACTORS \"\"; \"\"STRESS RESPONSE TO ENDOGENOUS AND EXOGENOUS DNA-DAMAGING AGENTS\"\"; \"\"TRANSLESION DNA SYNTHESIS \"\""]
[{"$nulls":4},"\"\"THE GENERAL STRESS RESPONSE \"\""]
[null,null,null,"Sommario/riassunto","This work looks at how genome stability depends on the complex interaction of predefined and environmentally induced genetic and epigenetic states. It describes various phenomena associated with the maintenance of genome stability, including genetic and epigenetic responses to various stresses in exposed cells and organisms."]