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[null,"1.","Record Nr.",null,"UNINA9910973813403321"]
[null,null,"Titolo",null,"Toxicological effects of methylmercury / / Committee on the Toxicological Effects of Methylmercury, Board on Environmental Studies and Toxicology, Commission on Life Sciences, National Research Council"]
[null,null,"Pubbl/distr/stampa",null,"Washington, DC, : National Academy Press, c2000"]
[null,null,"ISBN",null,"9786610185344"]
[{"$nulls":4},"9780309171717"]
[{"$nulls":4},"0309171717"]
[{"$nulls":4},"9781280185342"]
[{"$nulls":4},"1280185341"]
[{"$nulls":4},"9780309569705"]
[{"$nulls":4},"0309569702"]
[null,null,"Edizione",null,"[1st ed.]"]
[null,null,"Descrizione fisica",null,"1 online resource (368 p.)"]
[null,null,"Disciplina",null,"615.9/25663"]
[null,null,"Soggetti",null,"Methylmercury - Toxicology"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references."]
[null,null,"Nota di contenuto",null,"\"\"Toxicological Effects of Methylmercury\"\"; \"\"Copyright\"\"; \"\"PREFACE\"\"; \"\"Contents\"\"; \"\"EXECUTIVE SUMMARY\"\"; \"\"THE CHARGE TO THE COMMITTEE\"\"; \"\"THE COMMITTEE'S APPROACH TO ITS CHARGE\"\"; \"\"THE COMMITTEE'S EVALUATION\"\"; \"\"Health Effects of Methylmercury\"\"; \"\"Determination of the Critical Study for the RfD\"\"; \"\"Estimation of Dose and Biological Variability\"\"; \"\"Modeling the Dose-Response Relationships\"\"; \"\"Public Health Implications\"\"; \"\"RESEARCH NEEDS\"\"; \"\"RECOMMENDATIONS\"\"; \"\"1 INTRODUCTION\"\"; \"\"SOURCES OF HG\"\"; \"\"FATE AND TRANSPORT\"\"; \"\"HEALTH EFFECTS\"\"; \"\"EXPOSURE EVENTS AND STUDIES\"\""]
[{"$nulls":4},"\"\"SUMMARY OF RISK ASSESSMENTS FOR MEHG\"\"\"\"SCIENTIFIC CONTROVERSIES AND SOURCES OF UNCERTAINTY\"\"; \"\"ORGANIZATION OF THE REPORT\"\"; \"\"REFERENCES\"\"; \"\"2 CHEMISTRY, EXPOSURE, TOXICOKINETICS, AND TOXICODYNAMICS \"\"; \"\"PHYSICAL AND CHEMICAL PROPERTIES\"\"; \"\"METHODS OF CHEMICAL ANALYSIS\"\"; \"\"EXPOSURES TO MEHG IN THE U.S. POPULATION\"\"; \"\"TOXICOKINETICS\"\"; \"\"Absorption and Distribution\"\"; \"\"Methylmercury\"\"; \"\"Dimethylmercury\"\"; \"\"Elemental Mercury\"\"; \"\"Inorganic Mercury\"\"; "]
[{"$nulls":4},"\"\"Biotransformation\"\"; \"\"Excretion\"\"; \"\"MOBILIZATION OF BODY HG\"\"; \"\"CHEMICAL FORMS OF HG IN TOXICITY\"\""]
[{"$nulls":4},"\"\"TOXIC EFFECTS AND TARGET ORGANS\"\"\"\"BIOCHEMICAL MECHANISMS OF TOXICITY\"\"; \"\"SUMMARY AND CONCLUSIONS\"\"; \"\"RECOMMENDATIONS\"\"; \"\"REFERENCES\"\"; \"\"3 BIOLOGICAL VARIABILITY \"\"; \"\"AGE-RELATED SUSCEPTIBILITY\"\"; \"\"GENDER DIFFERENCES\"\"; \"\"GENETICS\"\"; \"\"MECHANISMS OF NUTRITIONAL INFLUENCE ON MEHG HEALTH EFFECTS\"\"; \"\"Dietary Interactions and Confounding\"\"; \"\"Selenium\"\"; \"\"Garlic\"\"; \"\"Omega-3 Fatty Acids\"\"; \"\"Protein\"\"; \"\"Alcohol\"\"; \"\"Other Foods That Might Influence Hg Uptake\"\"; \"\"Vitamin E\"\"; \"\"Nutrient Enhancement of Toxicity\"\"; \"\"Beneficial Effects of Fish Consumption\"\"; \"\"TOXICOKINETIC VARIABILITY\"\""]
[{"$nulls":4},"\"\"CONCLUSIONS\"\"\"\"RECOMMENDATIONS\"\"; \"\"REFERENCES\"\"; \"\"4 DOSE ESTIMATION \"\"; \"\"DIETARY ASSESSMENT\"\"; \"\"BIOMARKERS OF EXPOSURE\"\"; \"\"Methylmercury in Blood\"\"; \"\"Methylmercury in Hair\"\"; \"\"Comparison of Biomarkers of Exposure\"\"; \"\"ANALYTICAL ERROR IN BIOMARKER MEASUREMENTS\"\"; \"\"EXPOSURE AND DOSE ASSESSMENT IN THE SEYCHELLES, FAROE ISLANDS, AND NEW ZEALAND STUDIES\"\"; \"\"SUMMARY AND CONCLUSIONS\"\"; \"\"RECOMMENDATIONS\"\"; \"\"REFERENCES\"\"; \"\"5 HEALTH EFFECTS OF METHYLMERCURY \"\"; \"\"CARCINOGENICITY\"\"; \"\"Human Studies\"\"; \"\"Animal Studies\"\"; \"\"GENOTOXICITY\"\"; \"\"Human Studies\"\"; \"\"Animal Studies\"\""]
[{"$nulls":4},"\"\"In Vitro Studies\"\"\"\"IMMUNOTOXICITY\"\"; \"\"Human Studies\"\"; \"\"Animal Studies\"\"; \"\"Effects on the Adult Immune System\"\"; \"\"Effects on the Developing Immune System\"\"; \"\"In Vitro Studies\"\"; \"\"Autoimmune Response\"\"; \"\"Human Studies\"\"; \"\"Animal Studies\"\"; \"\"REPRODUCTIVE EFFECTS\"\"; \"\"Human Studies\"\"; \"\"Animal Studies\"\"; \"\"RENAL TOXICITY\"\"; \"\"Human Studies\"\"; \"\"Animal Studies\"\"; \"\"CARDIOVASCULAR EFFECTS\"\"; \"\"Human Studies\"\"; \"\"Animal Studies\"\"; \"\"HEMATOLOGICAL EFFECTS\"\"; \"\"DEVELOPING CENTRAL-NERVOUS-SYSTEM TOXICITY\"\"; \"\"Human Studies\"\"; \"\"High-Dose Poisonings\"\"; \"\"Poisoning Episode in Japan\"\""]
[{"$nulls":4},"\"\"Poisoning Episode in Iraq\"\""]
[null,null,null,"Sommario/riassunto","Mercury is widespread in our environment. Methylmercury, one organic form of mercury, can accumulate up the aquatic food chain and lead to high concentrations in predatory fish. When consumed by humans, contaminated fish represent a public health risk.  Combustion processes, especially coal-fired power plants, are major sources of mercury contamination in the environment. The U.S. Environmental Protection Agency (EPA) is considering regulating mercury emissions from those plants.  Toxicological Effects of Methylmercury reviews the health effects of methylmercury and discusses the estimation of mercury exposure from measured biomarkers, how differences between individuals affect mercury toxicity, and appropriate statistical methods for analysis of the data and thoroughly compares the epidemiological studies available on methylmercury. Included are discussions of current mercury levels on public health and a delineation of the scientific aspects and policy decisions involved in the regulation of mercury.  This report is a valuable resource for individuals interested in the public health effects and regulation of mercury. The report also provides an excellent example of the implications of decisions in the risk assessment process for a larger audience."]