{"text_format":"2","workbook":"xls","n_sheets":1,"sheets":["report2"],"not_rendered":{"charts":0,"images":0,"macros":0,"external_links":1,"defined_names":1,"comments":0,"pivot_tables":0},"unopened":[],"bounds":{"document_bytes":16777216,"sheet_cells":100000,"run_cost":"one","rows_first":2000,"rows_last":500,"rows_between":2000,"halvings":0,"cell_chars":16384,"cell_head_chars":4096},"cells_cut":0,"cells_raw":0,"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"report2","index":0,"n_rows":21,"n_cols":5,"rows_kept":21,"cut":false,"hidden":false,"merged":[[0,2,0,3],[0,4,0,5],[1,2,1,3],[1,4,1,5],[2,2,2,3],[2,4,2,5],[3,2,3,3],[4,2,4,3],[5,2,5,3],[6,2,6,3],[7,2,7,3],[8,2,8,3],[10,2,10,3],[11,2,11,3],[15,2,15,3]],"flags":["formulas_cached_only"]}
[null,"1.","Record Nr.",null,"UNINA9910971361403321"]
[null,null,"Autore",null,"Taupin Philippe"]
[null,null,"Titolo",null,"Stem cells and regenerative medicine . Volume 6 Molecular and cellular mechanisms / / Philippe Taupin"]
[null,null,"Pubbl/distr/stampa",null,"New York, : Nova Science Publishers, c2011"]
[null,null,"ISBN",null,"1-61761-388-6"]
[null,null,"Edizione",null,"[1st ed.]"]
[null,null,"Descrizione fisica",null,"1 online resource (154 p.)"]
[null,null,"Collana",null,"Cell biology research progress"]
[null,null,"Soggetti",null,"Stem cells"]
[{"$nulls":4},"Regenerative medicine"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references and index."]
[null,null,"Nota di contenuto",null,"Intro -- STEM CELLS AND REGENERATIVE MEDICINE. VOLUME 5.  PATENTS AND CLINICAL TRIALS -- STEM CELLS AND REGENERATIVE MEDICINE. VOLUME 5.  PATENTS AND CLINICAL TRIALS -- Contents -- Preface -- Introduction: Therapeutic Neuronal Stem Cells: Patents at the Forefront* -- Abstract -- 1. Background -- 2. Neural Stem Cells, Therapeutic Potential and Patents -- 3. Expert Opinion -- Acknowledgments -- References** -- Chapter I   Adult Neurogenesis and Pharmacology in Alzheimer's Disease and Depression -- Abstract -- Introduction -- Adult Neurogenesis in Alzheimer's Disease -- Adult Neurogenesis in Depression -- Discussion -- Conclusion and Perspectives -- Acknowledgments -- References -- Chapter II   Adult Neurogenesis in the Pathogenesis of Alzheimer's Disease -- Acknowledgments -- References -- Chapter III   Therapeutic Potential of Adult Neural Stem Cells* -- Abstract -- Introduction -- Neural Progenitor and Stem Cells -- Neural Progenitor and Stem Cells in Vitro -- Origin of Newly Generated Neuronal Cells in the Adult Brain -- Therapeutic Potential of Adult NSCs -- Cellular Therapy -- Gene Therapy -- Current and Future Developments -- References** -- Chapter IV   Human Neural Progenitor and Stem Cells* -- Abstract -- 1. Introduction -- 2. Chemistry -- 2.1 Proliferation Medium -- 2.2 Culture of Human Fetal Neural Progenitor and Stem Cells -- 3. Biology and Action -- 3.1 Growth Rate -- 3.2 Immunocytofluorescence -- 3.3 Differentiation of Human Fetal Neural Progenitor and Stem Cells -- 4. Expert Opinion -- Acknowledgments -- References** -- Chapter V   Cryopreservation of Early Postmitotic Neuronal Cells in Culture* -- Abstract -- 1. Introduction -- 2. Chemistry -- 2.1 Defined Derivation "]
[{"$nulls":4},"Medium -- 2.1.1 Defined Derivation Medium #1 -- 2.1.2 Defined Medium #2 -- 2.1.3 Defined Medium #3 -- 2.2 Induction Medium -- 2.2.1 Induction Medium."]
[{"$nulls":4},"2.3 Production of Neural Progenitor Cells from Embryonic Stem Cells -- 2.4 Induction of Neural Progenitor Cells into Neuronal or Neural-Like Cells -- 2.5 Cryopreservation -- 2.6 Thawing Cryopreserved Cells -- 2.7 Cultivation -- 3. Biology and Action -- 4. Expert Opinion -- Acknowledgments -- References** -- Chapter VI   Adult Neural Stem Cells for the Treatment of Neuroinflammation* -- Abstract -- 1. Introduction -- 2. Chemistry -- 3. Biology and Action -- 3.1 Relapsing-Remitting Model of Experimental Autoimmune Encephalomyelitis -- 3.2 Syngeneic Transplantation -- 3.3 In Situ Proliferation of Transplanted Anscs -- 3.4 Immunocytology and Immunohistology -- 4. Expert Opinion -- Acknowledgments -- References** -- Chapter VII   Adult Periodontal-Derived Neural Progenitor and Stem Cells* -- Abstract -- 1. Introduction -- 2. Chemistry -- 2.1 Periodontal Tissue -- 2.2 Cell Culture -- 2.3 Differentiation -- 2.4 Immunocytology -- 2.5 Organotypic Hippocampal Slice Cultures -- 2.6 Further Studies -- 3. Biology and Action -- 4. Expert Opinion -- Acknowledgments -- References** -- Chapter VIII   Magnetic Resonance Imaging for Monitoring Neurogenesis in the Adult Hippocampus* -- Abstract -- 1. Introduction -- 2. Chemistry -- 2.1 Experimental Study in Rats -- 2.2 MRI Scanning in Rats -- 2.3 Histology -- 2.4 Epidemiological Study -- 2.5 MRI Protocol in Human Subjects -- 3. Biology and Action -- 4. Expert Opinion -- Acknowledgments -- References** -- Chapter IX   Apigenin and Related Compounds Stimulate Adult Neurogenesis* -- Abstract -- 1. Introduction -- 2. Chemistry -- 2.1 Compounds and Derivatives -- 2.2 Synthesis -- 3. Biology and Action -- 3.1 Animal Studies -- 3.1.1 Intraperitoneal Administration of Apigenin -- 3.1.2 Oral Administration of Apigenin and Epicatechin -- 3.2 Immunohistology -- 3.3 Cell Culture -- 4. Expert Opinion -- Acknowledgments."]
[{"$nulls":4},"References** -- Chapter X   Nootropic Agents Stimulate Neurogenesis* -- Abstract -- 1. Introduction -- 2. Chemistry -- 2.1 Cell Culture -- 2.2 Differentiation -- 2.3 Immunocytochemistry -- 2.4 Novel Object Recognition Task -- 3. Biology and Action -- 4. Expert Opinion -- Acknowledgments -- References** -- Chapter XI   Fourteen Compounds and their Derivatives for the Treatment of Diseases and Injuries Characterized by Reduced Neurogenesis and Neurodegeneration* -- Abstract -- 1. Introduction -- 2. Chemistry -- 2.1 Compounds and Derivatives -- 2.2 Synthesis -- 3. Biology and Action -- 3.1 Cell Culture -- 3.2 Immunocytology -- 3.3 Apoptosis -- 3.4 Necrosis -- 3.5 Neuron Dysfunction -- 4. Expert Opinion -- Acknowledgments -- References** -- Chapter XII   Brevetoxin Derivative Compounds for Stimulating Neuronal Growth* -- Abstract -- 1. Introduction -- 2. Chemistry -- 3. Biology and Action -- 3.1 Primary Cell Culture of Neocortical Neurons -- 4. Expert Opinion -- Acknowledgments -- References** -- Chapter XIII   OTI-010 Osiris Therapeutics/JCR Pharmaceuticals* -- Summary -- Abstract -- Introduction -- Synthesis and SAR -- Preclinical Development -- In Vitro -- In Vivo -- Toxicity -- Clinical Development -- GVHD -- Transplantation in Cancer Patients -- Crohn's Disease -- Metabolism and Pharmacokinetics -- Side Effects and Contraindications -- Patent Summary -- Current Opinion -- Licensing -- JCR Pharmaceuticals Co Ltd -- Acknowledgments -- References -- Chapter XIV   ADA-Transduced Hematopoietic Stem Cell Therapy for ADA-SCID -- Summary -- Abstract -- Introduction -- Synthesis and SAR -- Preclinical Development -- Metabolism and Pharmacokinetics -- "]
[{"$nulls":4},"Toxicity -- Clinical Development -- Phase I/II -- Side Effects and Contraindications -- Patent Summary -- Current Opinion -- Acknowledgments -- References* -- Index."]
[null,null,null,"Sommario/riassunto","Stem cells are the building blocks of the body. They can develop into any of the cells that make up our bodies. Stem cells carry a lot of hope for the treatment of a broad range of diseases and injuries, spanning from cancers, diabetes, genetic diseases, graft-versus-host disease, eye, heart and liver diseases, inflammatory and autoimmune disorders, to neurological diseases and injuries, particularly neurodegenerative diseases, like Alzheimer's and Parkinson's diseases, cerebral strokes, and traumatic brain and spinal cord injuries. Stem cell research is therefore as important for understanding the Physio- and pathology of the body as for development and therapy as well as for understanding the nervous system. This book provides an overview and in-depth analysis of recent developments in stem cell research and therapy."]