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[null,"1.","Record Nr.",null,"UNINA9910970042803321"]
[null,null,"Titolo",null,"Adverse events associated with childhood vaccines : evidence bearing on causality / / Kathleen R. Stratton, Cynthia J. Howe, and Richard B. Johnston, Jr., editors"]
[null,null,"Pubbl/distr/stampa",null,"Washington, D.C., : National Academy Press, 1994"]
[null,null,"ISBN",null,"9786610196654"]
[{"$nulls":4},"9781280196652"]
[{"$nulls":4},"1280196653"]
[{"$nulls":4},"9780309576321"]
[{"$nulls":4},"0309576326"]
[{"$nulls":4},"9780585158693"]
[{"$nulls":4},"058515869X"]
[null,null,"Edizione",null,"[1st ed.]"]
[null,null,"Descrizione fisica",null,"1 online resource (480 pages)"]
[null,null,"Disciplina",null,"615/.372/083"]
[null,null,"Soggetti",null,"Vaccination of children - Complications"]
[{"$nulls":4},"Vaccines - Health aspects"]
[{"$nulls":4},"Vaccines - Toxicology"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","\"Vaccine Safety Committee, Division of Health Promotion and Disease Prevention, Institute of Medicine.\""]
[{"$nulls":4},"\"The project was supported by funds coordinated through the National Institute of Allergy and Infectious Diseases of the National Institutes of Health (contract no. NO-AI-15130)\"--T.p. verso."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references (p. 348-450) and index."]
[null,null,"Nota di contenuto",null,"Adverse Events Associated with CHILDHOOD VACCINES -- Copyright -- Preface -- Acknowledgments -- Contents -- 1 Executive Summary -- BACKGROUND AND HISTORY -- THE CHARGE TO THE COMMITTEE -- THE STUDY PROCESS -- CAUSALITY AND WEIGHT OF EVIDENCE -- NEED FOR RESEARCH AND SURVEILLANCE -- REFERENCES -- 2 Causality and Evidence -- CAUSALITY -- Definitions -- Types of Causal Questions -- Can It? -- Did It? -- Will It? -- SOURCES OF EVIDENCE FOR CAUSALITY -- Biologic Plausibility -- Case Reports, Case Series, and Uncontrolled Observational Studies -- Controlled Observational Studies -- Controlled Clinical Trials -- Combining the Evidence -- SUMMARIZING THE EVIDENCE FOR CAUSALITY -- REFERENCES -- 3 Neurologic Disorders -- DEMYELINATING DISEASE -- Experimental Models -- Acute Disseminated Encephalomyelitis -- Multiple Sclerosis -- Focal "]
[{"$nulls":4},"Lesions -- Guillain-Barré Syndrome -- Historical Background -- Clinical and Laboratory Features -- Diagnostic Criteria -- Antecedent Events -- Pathology and Pathogenesis -- Descriptive Epidemiology -- Summary of Demyelinating Diseases -- NON-DEMYELINATING DISEASE -- Encephalopathy -- Subacute Sclerosing Panencephalitis -- Clinical and Laboratory Features -- Pathology and Pathogenesis -- Descriptive Epidemiology -- Residual Seizure Disorder -- Sensorineural Deafness -- Neuropathy -- Mononeuropathy -- Brachial Neuritis -- REFERENCES -- 4 Immunologic Reactions -- ANAPHYLAXIS -- INTERACTION OF ANTIBODY WITH NORMAL TISSUE ANTIGENS -- ARTHUS REACTION -- DELAYED-TYPE HYPERSENSITIVITY -- EFFECT OF VACCINES ON THE IMMUNE SYSTEM -- REFERENCES -- 5 Diphtheria and Tetanus Toxoids -- BACKGROUND AND HISTORY -- Tetanus -- Diphtheria -- BIOLOGIC EVENTS FOLLOWING IMMUNIZATION -- Tetanus -- Diphtheria -- ENCEPHALOPATHY -- Clinical Description -- History of Suspected Association -- Evidence for Association -- Biologic Plausibility."]
[{"$nulls":4},"Case Reports, Case Series, and Uncontrolled Observational Studies -- Controlled Observational Studies -- Controlled Clinical Trials -- Causality Argument -- Conclusion -- RESIDUAL SEIZURE DISORDER -- Clinical Description -- History of Suspected Association -- Evidence for Association -- Biologic Plausibility -- Case Reports, Case Series, and Uncontrolled Observational Studies -- Controlled Observational Studies -- Controlled Clinical Trials -- Causality Argument -- Conclusion -- DEMYELINATING DISEASES OF THE CENTRAL NERVOUS SYSTEM -- Clinical Description -- History of Suspected Association -- Evidence for Association -- Biologic Plausibility -- Case Reports, Case Series. and Uncontrolled Observational Studies -- Controlled Observational Studies -- Controlled Clinical Trials -- Causality Argument -- Conclusion -- GUILLAIN-BARRÉ SYNDROME -- Clinical Description -- History of Suspected Association -- Evidence for Association -- Biologic Plausibility -- Case Reports, Case Series, and Uncontrolled Observational Studies -- Controlled Observational Studies -- Controlled Clinical Trials -- Causality Argument -- Conclusion -- Risk-Modifying Factors -- NEUROPATHY -- Clinical Description -- History of Suspected Association -- Evidence for Association -- Biologic Plausibility -- Case Reports, Case Series, and Uncontrolled Observational Studies -- Controlled Observational Studies -- Controlled Clinical Trials -- Causality Argument -- Conclusion -- Risk-Modifying Factors -- ARTHRITIS -- Clinical Description -- History of Suspected Association -- Evidence for Association -- Biologic Plausibility -- Case Reports, Case Series, and Uncontrolled Observational Studies -- Controlled Observational Studies -- Controlled Clinical Trials -- Causality Argument -- Conclusion -- ERYTHEMA MULTIFORME -- Clinical Description -- History of Suspected Association."]
[{"$nulls":4},"Evidence for Association -- Biologic Plausibility -- Case Reports, Case Series, and Uncontrolled Observational Studies -- Controlled Observational Studies -- Controlled Clinical Trials -- Causality Argument -- Conclusion -- ANAPHYLAXIS -- Clinical Description -- History of Suspected Association -- Evidence for Association -- Biologic Plausibility -- Case Reports, Case Series, and Uncontrolled Observational Studies -- Controlled Observational Studies -- Controlled Clinical Trials -- Causality Argument -- Conclusion -- Risk-Modifying Factors -- DEATH -- Causality Argument -- Conclusion -- REFERENCES -- 6 Measles and Mumps Vaccines -- BACKGROUND AND HISTORY -- Measles -- Mumps -- BIOLOGIC EVENTS FOLLOWING IMMUNIZATION -- Measles -- Mumps -- ENCEPHALOPATHY AND ENCEPHALITIS -- Clinical Description -- History of Suspected "]
[{"$nulls":4},"Association -- Evidence for Association -- Biologic Plausibility -- Case Reports, Case Series, and Uncontrolled Observational Studies -- Controlled Observational Studies -- Controlled Clinical Trials -- Causality Argument -- Conclusion -- ASEPTIC MENINGITIS -- Clinical Description -- History of Suspected Association -- Evidence for Association -- Biologic Plausibility -- Case Reports, Case Series, and Uncontrolled Observational Studies -- Controlled Observational Studies -- Controlled Clinical Trials -- Causality Argument -- Conclusion -- SUBACUTE SCLEROSING PANENCEPHALITIS -- Clinical Description -- History of Suspected Association -- Evidence for Association -- Biologic Plausibility -- Case Reports, Case Series, and Uncontrolled Observational Studies -- Controlled Observational Studies -- Controlled Clinical Trials -- Causality Argument -- Conclusion -- RESIDUAL SEIZURE DISORDER -- Clinical Description -- Evidence for Association -- Biologic Plausibility -- Case Reports, Case Series, and Uncontrolled Observational Studies."]
[{"$nulls":4},"Controlled Observational Studies -- Controlled Clinical Trials -- Causality Argument -- Conclusion -- SENSORINEURAL DEAFNESS -- Clinical Description -- History of Suspected Association -- Evidence for Association -- Biologic Plausibility -- Case Reports, Case Series, and Uncontrolled Observational Studies -- Controlled Observational Studies -- Controlled Clinical Trials -- Causality Argument -- Conclusion -- OPTIC NEURITIS -- Clinical Description -- History of Suspected Association -- Evidence for Association -- Biologic Plausibility -- Case Reports, Case Series, and Uncontrolled Observational Studies -- Controlled Observational Studies -- Controlled Clinical Trials -- Causality Argument -- Conclusion -- TRANSVERSE MYELITIS -- Clinical Description -- History of Suspected Association -- Evidence for Association -- Biologic Plausibility -- Case Reports, Case Studies, and Uncontrolled Observational Studies -- Controlled Observational Studies -- Controlled Clinical Trials -- Causality Argument -- Conclusion -- GUILLAIN-BARRÉ SYNDROME -- Clinical Description -- History of Suspected Association -- Evidence for Association -- Biologic Plausibility -- Case Reports, Case Series, and Uncontrolled Observational Studies -- Controlled Observational Studies -- Controlled Clinical Trials -- Causality Argument -- Conclusion -- INSULIN-DEPENDENT DIABETES MELLITUS -- Clinical Description -- History of Suspected Association -- Evidence for Association -- Plausibility -- Case Reports, Case Series, and Uncontrolled Observational Studies -- Controlled Observational Studies -- Controlled Clinical Trials -- Causality Argument -- Conclusion -- STERILITY DUE TO ORCHITIS -- Clinical Description -- History of Suspected Association -- Evidence for Association -- Biologic Plausibility -- Case Reports, Case Series, and Uncontrolled Observational Studies."]
[{"$nulls":4},"Controlled Observational Studies -- Controlled Clinical Trials -- Causality Argument -- Conclusion -- THROMBOCYTOPENIA -- Clinical Description -- History of Suspected Association -- Evidence for Association -- Biologic Plausibility -- Case Reports, Case Series, and Uncontrolled Observational Studies -- Controlled Observational Studies -- Controlled Clinical Trials -- Causality Argument -- Conclusion -- Risk-Modifying Factors -- ANAPHYLAXIS -- Clinical Description -- History of Suspected Association -- Evidence for Association -- Biologic Plausibility -- Case Reports, Case Series, and Uncontrolled Observational Studies -- Controlled Observational Studies -- Controlled Clinical Trials -- Causality Argument -- Conclusion -- Risk-Modifying Factors -- DEATH -- Causality Argument -- Conclusion -- REFERENCES -- 7 Polio Vaccines -- BACKGROUND AND HISTORY -- "]
[{"$nulls":4},"BIOLOGIC EVENTS FOLLOWING IMMUNIZATION -- POLIOMYELITIS -- Clinical Description -- History of Suspected Association -- Evidence for Association -- Biologic Plausibility -- Case Reports, Case Series, and Uncontrolled Observational Studies -- Controlled Observational Studies -- Controlled Clinical Trials -- Causality Argument -- Conclusion -- Risk-Modifying Factors -- TRANSVERSE MYELITIS -- Clinical Description -- History of Suspected Association -- Evidence for Association -- Biologic Plausibility -- Case Reports, Case Series, and Uncontrolled Observational Studies -- Controlled Observational Studies -- Controlled Clinical Trials -- Causality Argument -- Conclusion -- GUILLAIN-BARRÉ SYNDROME -- Clinical Description -- History of Suspected Association -- Evidence for Association -- Biologic Plausibility -- Case Reports, Case Series, and Uncontrolled Observational Studies -- Controlled Observational Studies -- Controlled Clinical Trials -- Causality Argument -- Conclusion -- Risk-Modifying Factors."]
[{"$nulls":4},"ANAPHYLAXIS AND THROMBOCYTOPENIA."]
[null,null,null,"Sommario/riassunto","Childhood immunization is one of the major public health measures of the 20th century and is now receiving special attention from the Clinton administration. At the same time, some parents and health professionals are questioning the safety of vaccines because of the occurrence of rare adverse events after immunization. This volume provides the most thorough literature review available about links between common childhood vaccines--tetanus, diphtheria, measles, mumps, polio, Haemophilus influenzae b,  and hepatitis B--and specific types of disorders or death. The authors discuss approaches to evidence and causality and examine the consequences--neurologic and immunologic disorders and death--linked with immunization. Discussion also includes background information on the development of the vaccines and details about the case reports, clinical trials, and other evidence associating each vaccine with specific disorders. This comprehensive volume will be an important resource to anyone concerned about the immunization controversy: public health officials, pediatricians, attorneys, researchers, and parents."]