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[null,"1.","Record Nr.",null,"UNINA9910968093403321"]
[null,null,"Autore",null,"Cohen-Haguenauer Odile"]
[null,null,"Titolo",null,"The clinibook : clinical gene transfer : state of the art / / edited by Odile Cohen-Haguenauer"]
[null,null,"Pubbl/distr/stampa",null,"Paris, : EDP Sciences, 2012"]
[null,null,"ISBN",null,"9781299276826"]
[{"$nulls":4},"1299276822"]
[{"$nulls":4},"9782842542375"]
[{"$nulls":4},"2842542371"]
[null,null,"Edizione",null,"[1st ed.]"]
[null,null,"Descrizione fisica",null,"1 online resource (589 p.)"]
[null,null,"Disciplina",null,"571.96"]
[null,null,"Soggetti",null,"Genetic transformation"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references and index."]
[null,null,"Nota di contenuto",null,"pt. 1. Technologies and pre-clinical studies -- pt. 2. Clinical trials and regulatory issues."]
[null,null,null,"Sommario/riassunto","This book provides a 2012 reference for state-of-the-art gene transfer technology and the different aspects of its clinical translation with a focus on European-based initiatives. As examples of successful outcomes, recent clinical trials are presented together with Ethical, Safety and Regulatory issues, which are discussed. The broad range of various technologies is covered whether addressing direct in vivo gene transfer like with AAV, Adeno or non-viral vectors or ex-vivo genetically engineered cells including induced pluripotent stem cells (iPS) with integrating vectors such as retrovirus, lentivirus or transposon-derived systems. The critical path to clinical implementation is covered in the second part describing currently available tools - such as molecular imaging, ex-vivo organ cultures and high-throughput technologies used for evaluation of criteria towards a go-or-no go decision to move to the clinic; in addition, utmost salient biosafety and immunotoxicology aspects are discussed. This book is ideal for postgraduates, undergraduates, scientists, clinicians, regulators and patients' advocacy groups looking for states-of-the-art information as well as emerging prospects - including gene targeting and homologous recombination - in gene transfer intended for clinical translation."]
[null,"2.","Record Nr.",null,"UNINA9910962967203321"]
[null,null,"Autore",null,"Kuznetsov Yury V"]
[null,null,"Titolo",null,"Ambiol as base of new effective drugs / / Yury V. Kuznetsov"]
[null,null,"Pubbl/distr/stampa",null,"New York, : Nova Science Publishers, c2008"]
[null,null,"ISBN",null,"1-61209-819-3"]
[null,null,"Edizione",null,"[1st ed.]"]
[null,null,"Descrizione fisica",null,"1 online resource (59 p.)"]
[null,null,"Disciplina",null,"613.2/8"]
[null,null,"Soggetti",null,"Ethephon - Therapeutic use"]
[{"$nulls":4},"Antioxidants - Therapeutic use"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Includes index."]
[null,null,"Nota di contenuto",null,"Intro -- AMBIOL AS A BASIS OFNEW EFFECTIVE DRUGS -- AMBIOL AS A BASIS OF NEW EFFECTIVE DRUGS -- CONTENTS -- PREFACE -- ABBREVIATIONS -- INTRODUCTION -- ATHEROSCLEROSIS, ISCHEMIC ILLNESS OF THE HEART, INFARCTION OF CARDIAC MUSCLE, THROMBOSIS, CEREBRAL THROMBOSIS AND HIGH CHOLESTEROL -- ONCOLOGIC DISEASES, RADIATION EFFECTS(BEAM ILLNESS), GASTRITIS, STOMACH ULCERS AND ULCERS OF THE DUODENUM -- BRONCHO PULMONIC PATHOLOGIES, ASTHMA AND ADVERSE CONSEQUENCES OF OXYGEN THERAPY -- IMMUNE SYSTEM, AGING, ALLERGY,INFLAMMATION AND INFECTIOUS ILLNESSES -- PAIN, STRESS AND NEUROLOGICAL ACTIVITY -- IMPAIRMENT OF SEXUAL AND REPRODUCTIVE FUNCTIONS (IMPOTENCE, GYNAECOLOGICAL DISEASES AND INFERTILITY) -- PROTECTIVE EFFECT IN VITAMIN DEFICIENCY -- PREVENTIVE MAINTENANCE AND TREATMENT OF INTOXICATION(INDUSTRIAL, PLANT AND ANIMAL POISONS) -- AND HELP IN WEIGHT LOSS, SMOKING CESSATION, HEMOCHROMATOSIS (SURPLUSOF NON-HEME IRON) AND VISION -- TREATMENT OF HAIR LOSS, OILY AND DRY SEBORRHEA, CHEMICAL AND THERMAL BURNS AND FROSTBITE -- SKIN REJUVENATION, PREVENTION OF SKIN AGING, REMOVAL OF KELOIDAL CICATRICES(SCARS) AND SUNBURN PROTECTION -- PRESERVATION AND IMPROVEMENT IN THE PROPERTIES OF FOOD AND COSMETIC PRODUCTS -- CONCLUSION -- INDEX."]
[null,null,null,"Sommario/riassunto","This work looks at new effective drugs. It covers the immune system, infectious illnesses, prevention of aging skin, preservation and improvement of properties of products of nourishment, and much more."]