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[null,"1.","Record Nr.",null,"UNINA990009633440403321"]
[null,null,"Autore",null,"Durand, Jean Nicolas Louis <1760–1834>"]
[null,null,"Titolo",null,"Recueil et parallèle des édifices en tout genre, anciens et modernes, remarquables par leur beauté, par leur grandeur ou par leur singularité dessines sur une même échelle / par J. N. L. Durand"]
[null,null,"Pubbl/distr/stampa",null,"Brouxelles : Meline Cans et C., [18..]"]
[null,null,"Descrizione fisica",null,"110 c. di tav : ill. ; 51X70 cm"]
[null,null,"Disciplina",null,"720"]
[null,null,"Locazione",null,"FINBC"]
[null,null,"Collocazione",null,"13 AR 9 C 23"]
[null,null,"Lingua di pubblicazione",null,"Francese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,"2.","Record Nr.",null,"UNINA9910960327803321"]
[null,null,"Titolo",null,"Virtual ADMET assessment in target selection and maturation / / edited by B. Testa and L. Turski"]
[null,null,"Pubbl/distr/stampa",null,"Amsterdam ; ; Washington, DC, : IOS Press, c2006"]
[null,null,"ISBN",null,"1-280-81056-4"]
[{"$nulls":4},"9786610810567"]
[{"$nulls":4},"1-4294-6772-X"]
[{"$nulls":4},"1-60750-219-4"]
[{"$nulls":4},"600-00-0604-7"]
[{"$nulls":4},"1-4337-0155-3"]
[null,null,"Edizione",null,"[1st ed.]"]
[null,null,"Descrizione fisica",null,"1 online resource (268 p.)"]
[null,null,"Collana",null,"Solvay Pharmaceuticals Conferences, , 1566-7685 ; ; v. 6"]
[null,null,"Disciplina",null,"615/.190285"]
[null,null,"Soggetti",null,"Drug development - Computer simulation"]
[{"$nulls":4},"Pharmacology"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Organized May 11-13th, 2005 in Lucerne, Switzerland."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references and index."]
[null,null,"Nota di contenuto",null,"Preface; List of Contributors; Contents; Conference Preface; The Risky Business of Developing Drugs; Benefits and Limits of in Silico Predictions; Musings on ADME Predictions and Molecular Structure; Lipophilicity: Its Calculation and Application in ADMET Predictions; Interpretation of the Role of the Electrotopological State and Molecular Connectivity Indices in the Prediction of Physical Properties and ADME-Tox Behavior - Case Study: Human Plasma Protein Binding; Molecular Descriptors for Predicting ADMET Properties; Molecular Fields to Assess Recognition Forces and Property Spaces"]
[{"$nulls":4},"Extracting Pharmacophores from Bio-Active MoleculesIn Silico Models for Human Bioavailability; In Silico Models to Predict Brain Uptake; Algorithms to Predict Affinity for Transporters; Predicting Affinity for and Metabolism by Cytochromes P450; Expert Systems to Predict Biotransformation; Expert Systems to Predict Toxicity; From in Vivo to in Vitro/in Silico ADME: Progress and Challenges; Author Index"]
[null,null,null,"Sommario/riassunto","Today, biologists and medicinal chemists realize that there is a strong relationship between pharmacodynamic (what the drug does to the organism) and pharmacokinetic (what the organism does to the drug) effects. A significant contributing factor to the evolution in drug discovery was the methodological and technological revolution with the "]
[{"$nulls":4},"advent of combinatorial chemistry, high-throughput screening and profiling, and in silico prediction of target-based activity and ADMET (absorption, distribution, metabolism, excretion and toxicity) properties. High-throughput screening and in silico methods"]