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[null,"1.","Record Nr.",null,"UNINA9910957636303321"]
[null,null,"Titolo",null,"New developments in chromatin research / / Neil M. Simpson and Valerie J. Stewart, editors"]
[null,null,"Pubbl/distr/stampa",null,"New York, : Nova Science Publishers, 2012"]
[null,null,"ISBN",null,"1-62081-832-9"]
[null,null,"Edizione",null,"[1st ed.]"]
[null,null,"Descrizione fisica",null,"1 online resource (249 p.)"]
[null,null,"Collana",null,"Genetics--research and issues"]
[{"$nulls":4},"Cell biology research progress"]
[null,null,"Disciplina",null,"572.8/7"]
[null,null,"Soggetti",null,"Chromatin - Research - Methodology"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Nova biomedical."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references and index."]
[null,null,"Nota di contenuto",null,"Intro -- Library of Congress Cataloging-in-Publication Data -- Contents -- Preface -- The Varied Functions of Aurora Kinases A and B in Mitosis and Carcinogenesis -- Abstract -- Introduction -- Aurora A Kinase -- Aurora A Localization -- Regulation of Aurora A Protein Levels -- Aurora A Mitotic Functions -- Aurora A Functions in Mitotic Entry and Centrosomal Regulation -- Aurora A Functions in Spindle Assembly -- Regulation of Aurora A Activity -- Aurora A and Cancer -- Aurora B Kinase -- Aurora B Localization -- Regulation of Aurora B Levels -- Regulation of Aurora B Activity -- Aurora B Mitotic Functions -- Aurora B Functions in Chromosome Structure and Alignment -- Aurora B Functions in Chromosome Segregation and Anaphase Onset -- Aurora B Functions in Cytokinesis -- Aurora B and Cancer -- Perspectives - Is there a Signaling Cross-Talk  between Aurora A and Aurora B? -- Acknowledgments -- References -- Chromatin Structure and Epigenetics -- Abstract -- 1. Introduction -- 2. Chromatin Structure and Nucleosome Dynamics -- 2.1. DNA Structure and Chromatin Fibers -- 2.2. Nucleosome Positioning -- 2.3. Nucleosome Dynamics and Gene Regulation -- 3. Histone Post-Translational Modifications and Chromatin Structure -- 3.1. Types of Histone Post-Translational Modifications -- 3.1.1. Histone Acetylation -- 3.1.2. Histone Methylation -- 3.1.3. Other Modifications -- 3.2. Crosstalk between Histone Post-Translational Modifications -- 3.3. Distribution of Histone PTMs within Genomic Domains -- 4. DNA Modifications and Chromatin Structure -- 4.1. DNA Methylation and Demethylation -- 4.1.1. DNA Methylation -- 4.1.2. DNA Demethylation -- 4.2. Crosstalk between DNA Marks and Histone PTMs -- 4.3. MBP Function as "]
[{"$nulls":4},"Chromatin Architectural Proteins -- Conclusion -- Acknowledgements -- Grant Information -- References."]
[{"$nulls":4},"Sperm Chromatin Integrity, DNA Fragmentation and Male Fertility -- Abstract -- 1. Sperm Chromatin Structure -- Balhorn's Model -- Toroids -- Histone Bound DNA -- Chromatin Remodelling during Spermatogenesis -- Chromosome Territories -- 2. Sperm Chromatin Integrity, DNA Fragmentation and Male Fertility -- Origin of Sperm DNA Fragmentation -- Incomplete Repair of DNA Breaks during Chromatin Remodelling -- Aberrant Protamination -- Defective Apoptosis -- Excessive Production of ROS in the Ejaculate -- Other Factors -- Methods of Evaluation of Sperm DNA Fragmentation -- Sperm Chromatin Structure Assay (SCSA) -- Terminal Deoxytransferase Mediated deoxyUridine Triphosphate Nick End Labelling (TUNEL) -- Comet Assay -- Sperm Chromatin Dispersion Test -- Impact of Sperm Nuclear Integrity on Male Fertility -- Impact of Sperm Nuclear Integrity on Reproduction -- Natural Conception -- ART Conception -- 3. Future Perspectives -- Fundamental Research Is Essential -- Standardization of the Methods for Sperm DNA Damage Evaluation -- Questions Concerning Factors Influencing the Predictive Value of SDF -- Long-Term Follow Up of ART Children -- References -- The Chromatin State of Pluripotent  Stem Cells -- Abstract -- Introduction -- Regulation of Pluripotency in ESCs -- Higher-order Chromatin Architecture in ESCs -- Chromatin Structure in ESCs -- Chromatin Bivalency in ESCs -- ATP-Dependent Chromatin Remodeling -- Histone Variants and Exchange of Histones -- Role of Chromatin in iPSC Generation -- Epigenetic Regulation during iPSC Generation -- Conclusion -- References -- MITF Meets Chromatin in Melanoma -- Abstract -- Introduction -- MITF and Melanoma -- The SWI/SNF Complex -- SWI/SNF in Differentiation and Cancer -- MITF and SWI/SNF in Melanoma -- Conclusion -- Acknowledgments -- Conflict of Interest -- References."]
[{"$nulls":4},"The State of Chromatin as  an Integrative Indicator  of Cell Stress -- References -- A Genomics Approach to Analysing DNA Damage and Its Repair throughout  Entire Genomes -- Abstract -- Introduction -- Materials and Methods -- UV Irradiation -- DNA Preparation -- Fragmenting DNA by Sonication -- Immunoprecipitation (IP) -- Repair of DNA Damages Prior to PCR Amplification -- PCR Amplification -- Labelling -- Hybridization -- Feature Extraction -- Results -- Detecting CPDs Throughout the Entire Yeast Genome -- Repair of CPDs in Wild Type and rad4 Cells -- Discussion -- Supplementary Data -- Funding -- References -- Recent Patent on Revolver-2:  A Novel Transposon-Like Gene Useful for Chromosome Tags of Rye -- Abstract -- Large Gaps of DNA Markers in the Rye Genome -- Rye Genome Specific Transposon-Like -- Gene-Family Revolver -- Highly Quantitative and Structural -- Diversity of Revolver -- Chromosome Tags by Using Revolver -- Current and Future Development -- Acknowledgments -- References -- The Removal of DNA Damage Is Promoted by the Yeast Global Genome Nucleotide Excision Repair Factor Rad16 -- Abstract -- Introduction -- Materials and Methods -- Plasmids and Yeast Strains -- UV Survival Assays -- Chromatin Immunoprecipitation (CHIP) -- Chromatin Preparation, Mnase Digestion, and the High-Resolution Nucleosome Mapping -- Restriction Enzyme Accessibility -- Preparation of Radioactive Probes for Southern Blot Analysis -- UV Treatment of Yeast Cells, DNA Isolation and High Resolution Mapping of CPD Sites -- Results -- UV Induced Histone H3 Acetylation (K9, K14) Requires Both Rad7 and Rad16 -- Rad7 and Rad16 Control H3Ac Status by Regulating Gcn5 Occupancy at MFA2 -- Histone H3 Acetylation Regulates Chromatin Structure at the Promoter of MFA2 -- Increased Histone H3 Acetylation Levels at MFA2 in TUP1 "]
[{"$nulls":4},"Deleted ( Cells Is Dependent on Gcn5 and Rad16."]
[{"$nulls":4},"Increased Chromatin Accessibility at MFA2 in TUP1 Deleted ( Cells Depends on Rad16 and Gcn5 -- Increased Histone H3 Acetylation Levels and Open Chromatin Structure are Required for Rad7 and Rad16 Independent GG-NER -- The Atpase and RING Domains of Rad16 Both Contribute to Efficient UV Survival -- The Atpase and RING Domains of Rad16 Are Both Required for UV Induced Gcn5 Occupancy and Histone H3 Acetylation -- The Atpase and RING Domains of Rad16 Are Both Required for Efficient GG-NER -- Discussion -- Acknowledgments -- References -- Chromatin Condensation in Infertile Sperm -- Abstract -- Introduction -- Chromatin Condensation during Spermatogenesis -- DNA Packaging in Mammalian Male Germ Cells -- Human Male Infertility -- Etiology of Sperm DNA Damage -- Protamine Deficiency -- Apoptosis -- Drugs, Chemotherapy, and Radiotherapy -- Reactive Oxygen Species -- Cigarette Smoking -- Post-Testicular Factors -- Varicoceles -- Mechanisms of Sperm DNA Damage -- Evaluation of Sperm DNA Damage -- The Comet Assay -- Terminal dUTP Nick-End Labeling (TUNEL) Assay -- Sperm Chromatin Structure Assay (SCSA) -- Toluidine Blue Staining -- Chromomycin A3 (CMA3) Assay -- Ultrastructure of Spermatozoa from Infertile Men -- Clinical Significance of Sperm DNA Damage -- Conclusion -- References -- Glucocorticoid-Induced Chromatin Remodeling: A Novel Molecular Mechanism of Traumatic Stress -- Abstract -- Introduction -- Chromatin Remodeling -- Chromatin Remodeling, p11 and PTSD -- Chromatin, Memory and Depression -- Conclusion -- References -- Index."]
[null,null,null,"Sommario/riassunto","Chromatin is DNA plus the proteins (and RNA) that package DNA within the cell nucleus. The primary functions of chromatin are: to package DNA into a smaller volume to fit in the cell, to strengthen the DNA to allow mitosis and meiosis and prevent DNA damage, and to control gene expression and DNA replication. In this book, the authors present topical research in the study of chromatin including the varied functions of aurora kinases A and B in mitosis and carcinogenesis; the chromatin state of pluripotent stem cells; MITF meets chromatin in melanoma; the state of chromatin as an integrative indicator of cell stress; analysing DNA damage and its repair throughout entire genomes; the cloning process, structural characterisation of Revolver transposon and its patented application for chromosome tags; DNA damage and Rad16; and glucocorticoid-induced chromatin remodelling."]
[null,"2.","Record Nr.",null,"UNINA9910298995803321"]
[null,null,"Titolo",null,"Advances in Digital Forensics X : 10th IFIP WG 11.9 International Conference, Vienna, Austria, January 8-10, 2014, Revised Selected Papers / / edited by Gilbert Peterson, Sujeet Shenoi"]
[null,null,"Pubbl/distr/stampa",null,"Berlin, Heidelberg : , : Springer Berlin Heidelberg : , : Imprint : Springer, , 2014"]
[null,null,"ISBN",null,"3-662-44952-8"]
[null,null,"Edizione",null,"[1st ed. 2014.]"]
[null,null,"Descrizione fisica",null,"1 online resource (XX, 335 p. 67 illus.)"]
[null,null,"Collana",null,"IFIP Advances in Information and Communication Technology, , 1868-422X ; ; 433"]
[null,null,"Disciplina",null,"364.168"]
[null,null,"Soggetti",null,"Data protection"]
[{"$nulls":4},"Computers and civilization"]
[{"$nulls":4},"Electronic commerce"]
[{"$nulls":4},"Information technology - Management"]
[{"$nulls":4},"Cryptography"]
[{"$nulls":4},"Data encryption (Computer science)"]
[{"$nulls":4},"Data and Information Security"]
[{"$nulls":4},"Computers and Society"]
[{"$nulls":4},"e-Commerce and e-Business"]
[{"$nulls":4},"Computer Application in Administrative Data Processing"]
[{"$nulls":4},"Cryptology"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Bibliographic Level Mode of Issuance: Monograph"]
[null,null,"Nota di contenuto",null,"Conditional Weighted Transaction Aggregation for Credit Card Fraud Detection -- Using Fraud Trees to Analyze Internet Credit Card Fraud -- Automated Analysis of Underground Marketplaces -- An Exploratory Profiling Study of Online Auction Fraudsters -- Web User Profiling Based on Browsing Behavior Analysis -- Validation Rules for Enhanced Foxy P2P Network Investigations -- Windows Event Forensic Process -- Schema Reconstruction in Database Forensics -- Analysis of the Use of XOR as an Obfuscation Technique in a Real Data Corpus -- Similarity Hashing Based on Levenshtein Distance -- Using Approximate Matching to Reduce the Volume of Digital Data -- Active Linguistic Authentication Using Real-Time Stylometric Evaluation for Multi-Modal Decision Fusion -- Breaking the Closed-World Assumption in Stylometric Authorship Attribution -- Preserving Dates and Timestamps "]
[{"$nulls":4},"for Incident Handling in Android Smartphones -- An Open Source Toolkit for iOS Filesystem Forensics -- Smartphones as Distributed Witnesses for Digital Forensics -- Smartphone Message Sentiment Analysis -- Forensic Analysis of the TomTom Navigation Application -- Performance of a Logical Five-Phase, Multithreaded, Bootable Triage Tool -- Towards Fully Automated Digital Alibis with Social Interactions -- Data Corpora for Digital Forensics Education and Research -- Educating the Next Generation of Cyberforensic Professionals."]
[null,null,null,"Sommario/riassunto","Digital forensics deals with the acquisition, preservation, examination, analysis and presentation of electronic evidence. Networked computing, wireless communications and portable electronic devices have expanded the role of digital forensics beyond traditional computer crime investigations. Practically every crime now involves some aspect of digital evidence; digital forensics provides the techniques and tools to articulate this evidence. Digital forensics also has myriad intelligence applications. Furthermore, it has a vital role in information assurance -- investigations of security breaches yield valuable information that can be used to design more secure systems. Advances in Digital Forensics X describes original research results and innovative applications in the discipline of digital forensics. In addition, it highlights some of the major technical and legal issues related to digital evidence and electronic crime investigations. The areas of coverage include: - Internet Crime Investigations; - Forensic Techniques; - Mobile Device Forensics; - Forensic Tools and Training. This book is the 10th volume in the annual series produced by the International Federation for Information Processing (IFIP) Working Group 11.9 on Digital Forensics, an international community of scientists, engineers and practitioners dedicated to advancing the state of the art of research and practice in digital forensics. The book contains a selection of twenty-two edited papers from the 10th Annual IFIP WG 11.9 International Conference on Digital Forensics, held in Vienna, Austria in the winter of 2014. Advances in Digital Forensics X is an important resource for researchers, faculty members and graduate students, as well as for practitioners and individuals engaged in research and development efforts for the law enforcement and intelligence communities."]