{"text_format":"2","workbook":"xls","n_sheets":1,"sheets":["report2"],"not_rendered":{"charts":0,"images":0,"macros":0,"external_links":1,"defined_names":2,"comments":0,"pivot_tables":0},"unopened":[],"bounds":{"document_bytes":16777216,"sheet_cells":100000,"run_cost":"one","rows_first":2000,"rows_last":500,"rows_between":2000,"halvings":0,"cell_chars":16384,"cell_head_chars":4096},"cells_cut":0,"cells_raw":0,"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"report2","index":0,"n_rows":41,"n_cols":5,"rows_kept":41,"cut":false,"hidden":false,"merged":[[0,2,0,3],[0,4,0,5],[1,2,1,3],[1,4,1,5],[2,2,2,3],[2,4,2,5],[3,2,3,3],[5,2,5,3],[7,2,7,3],[8,2,8,3],[9,2,9,3],[10,2,10,3],[15,2,15,3],[16,2,16,3],[20,2,20,3],[20,4,20,5],[21,2,21,3],[21,4,21,5],[22,2,22,3],[23,2,23,3],[24,2,24,3],[25,2,25,3],[26,2,26,3],[27,2,27,3],[28,2,28,3],[30,2,30,3],[31,2,31,3],[35,2,35,3]],"flags":["formulas_cached_only"]}
[null,"1.","Record Nr.",null,"UNINA9910467904503321"]
[null,null,"Autore",null,"Martin Lee <1955->"]
[null,null,"Titolo",null,"Telling stories : the craft of narrative and the writing life / / Lee Martin"]
[null,null,"Pubbl/distr/stampa",null,"Lincoln, Nebraska : , : University of Nebraska Press, , 2017"]
[{"$nulls":4},"©2017"]
[null,null,"ISBN",null,"1-4962-0293-7"]
[{"$nulls":4},"1-4962-0295-3"]
[null,null,"Descrizione fisica",null,"1 online resource (253 pages)"]
[null,null,"Classificazione",null,"LAN005000LAN002000"]
[null,null,"Disciplina",null,"808.02"]
[null,null,"Soggetti",null,"Authorship"]
[{"$nulls":4},"Creative writing"]
[{"$nulls":4},"Narration (Rhetoric)"]
[{"$nulls":4},"Storytelling"]
[{"$nulls":4},"Electronic books."]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Nota di bibliografia","Includes bibliographical references and index."]
[null,null,null,"Sommario/riassunto","\"A prolific and award-winning writer, Lee Martin has put pen to paper to offer his wisdom, honed during thirty years of teaching the oh-so-elusive art of writing. Telling Stories is intended for anyone interested in thinking more about the elements of storytelling in short stories, novels, and memoirs. Martin clearly delineates helpful and practical techniques for demystifying the writing process and providestools for perfecting the art of the scene, characterization, detail, point of view, language, and revision--in short, the art of writing. His discussion of the craft in his own life draws from experiences, memories, and stories to provide a more personal perspective on the elements of writing. Martin provides encouragement by sharing what he's learned from his journey through frustrations, challenges, and successes. Most important, Telling Stories emphasizes that you are not alone on this journey and that writers must remain focused on what they love: the process of moving words on the page. By focusing on that purpose, Martin contends, the journey will always take you where you're meant to go.\"--"]
[null,"2.","Record Nr.",null,"UNINA9910956968303321"]
[null,null,"Titolo",null,"Golgi apparatus : structure, functions and mechanisms / / Christopher J. Hawkins, editor"]
[null,null,"Pubbl/distr/stampa",null,"New York, : Nova Science Publishers, c2011"]
[null,null,"ISBN",null,"1-61122-611-2"]
[null,null,"Edizione",null,"[1st ed.]"]
[null,null,"Descrizione fisica",null,"1 online resource (181 p.)"]
[null,null,"Collana",null,"Cell biology research progress."]
[null,null,"Disciplina",null,"571.6/56"]
[null,null,"Soggetti",null,"Golgi apparatus"]
[{"$nulls":4},"Protoplasm"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references and index."]
[null,null,"Nota di contenuto",null,"Intro -- GOLGI APPARATUS  STRUCTURE, FUNCTIONS  AND MECHANISMS -- GOLGI APPARATUS  STRUCTURE, FUNCTIONS  AND MECHANISMS -- CONTENTS -- PREFACE -- Chapter 1    GOLGI ORGANIZATION AND STRESS SENSING -- ABSTRACT -- 1. INTRODUCTION -- 2. GOLGI STRUCTURE -- 2.a. The Intricacies of the Mammalian Golgi Apparatus -- 2.b. Golgi Ribbon Structure and Interaction with Other Organelles -- 2.c. Golgi Structure and Stacking -- 2.d. The Cytoskeleton and Maintenance of Golgi Ribbon Structure -- 2.d.1. Microtubules Maintain Golgi Ribbon Structure -- 2.d.2. The Actin Cytoskeleton and Golgi Structure -- 2.e. Contribution of Lipids to Golgi Structure and Function -- 2.e.1. Importance Of Glycerophospholipids In Golgi Structure And Function -- 2.e.2. Role of Sphingolipids and Lipid Transfer Proteins in Golgi Structure and Function -- 2.e.2.1. CERT and Stabilization of ER-Golgi Contact Sites -- 2.e.2.2. Role of FAPP2 and Transport of GlcCer Within the Golgi Apparatus -- 2.e.2.3. OSBP, Cholesterol Sensing and Maintainence of ER-Golgi Contact Sites -- 2.e.2.4. Sphingomyelin and CERT Function in Flies and Mammals -- 3. APOPTOSIS AND GOLGI STRUCTURAL ORGANIZATION -- 3.a. The Cellular Machinery for Apoptosis -- 3.b. Ceramide Mediated Apoptosis And Golgi Ribbon Architecture -- 3.b.1. Ceramide Biosynthesis and Metabolism -- 3.b.2. Ceramide Regulation and Golgi Structure -- 3.b.3. Ceramide and Apoptosis -- 4. CELLULAR LOCATION OF THE GOLGI APPARATUS  IN STRESS SENSING -- CONCLUSION -- REFERENCES -- Chapter 2    FUNCTIONAL RELATIONSHIPS BETWEEN  GOLGI DYNAMICS AND LIPID  METABOLISM AND TRANSPORT -- ABSTRACT -- ABBREVIATIONS -- 1. INTRODUCTION -- 2. LIPIDS AND PROTEINS "]
[{"$nulls":4},"INVOLVED IN MEMBRANE BUDDING -- 2.1. Adaptor/Clathrin-Coat Vesicle Formation at the Golgi -- 2.2. Formation of COPI Vesicles -- 2.3. Lipid Functions In Membrane Trafficking."]
[{"$nulls":4},"2.3.1. PtdOH, DAG, and Lyso-Phospholipids -- 2.3.1.1. PtdOH and DAG Synthesis and Interconversion -- 2.3.1.2. Roles for PtdOH and DAG in Vesicular Fission at the Golgi -- 2.3.1.3. Role of Lyso-PtdOH in Golgi Secretion -- 2.3.2. PtdIns-Polyphosphates -- 2.3.2.1. Roles of PtdInsP in Golgi Trafficking -- 2.3.2.2. PtdInsP Metabolism in the Golgi Apparatus -- 2.3.3. Cholesterol and Sphingolipids -- 2.3.3.1. Roles of the Golgi Apparatus in Cholesterol and Sphingolipid Homeostasis -- 2.3.3.2. Cholesterol Flux and Biosynthesis -- 2.3.3.3. Sphingolipid Biosynthesis -- 2.3.4. Lipid Transport Proteins Involved in Cholesterol and Sphingolipid Metabolism -- 2.3.4.1. Glycolipid Transfer by FAPP -- 2.3.4.2. Ceramide Transfer Protein -- 2.3.4.3. Golgi Cholesterol Transfer by OSBPs -- 3. PROTEINS INVOLVED IN MEMBRANE TETHERING AND FUSION -- 3.1. Vesicle Tethering at the Golgi -- 3.2. Vesicle Fusion Mediated by SNAREs -- 4. DISEASES RELATED TO LIPID METABOLISM AND GOLGI FUNCTION -- 4.1. Lowe Syndrome -- 4.2. Congenital Disorders of Glycosylation -- 4.3. Tangier Disease -- CONCLUSION -- REFERENCES -- Chapter 3    SIGNALING PATHWAYS CONTROLLING MITOTIC GOLGI BREAKDOWN IN MAMMALIAN CELLS -- ABSTRACT -- 1. INTRODUCTION -- 2. UNLINKING OF THE GOLGI RIBBON IN LATE G2 PHASE -- 3. GOLGI STACKS DISASSEMBLY AND VESICULATION -- 4. GOLGI APPARATUS INHERITANCE AND THE MITOTIC SPINDLE -- 5. GOLGI APPARATUS REASSEMBLY -- CONCLUSION -- ACKNOWLEDGMENTS -- REFERENCES -- Chapter 4    GOLGI APPARATUS AND  HYPERICIN-MEDIATED PHOTODYNAMIC ACTION -- ABSTRACT -- 1. AN ALTERNATIVE THERAPEUTIC MODALITY: PHOTODYNAMIC THERAPY -- 2. A PROMISING SECOND-GENERATION PHOTOSENSITIVE DRUG: HYPERICIN -- 3. THE MECHANISMS OF HYPERICIN-MEDIATED PDT AND GOLGI APPARATUS'S ROLE -- ACKNOWLEDGMENTS -- REFERENCES."]
[{"$nulls":4},"Chapter 5    ROLE OF THE TRANS-GOLGI NETWORK (TGN) IN THE SORTING OF NONENZYMIC  LYSOSOMAL PROTEINS -- ABSTRACT -- I. EVOLUTIONARY SORTING SYSTEMS IN THE TGN -- II. THE FUNCTION OF LYSOSOMAL PROTEINS -- Overview -- Lysosomal Functions of Sphingolipid Activator Proteins (SAPs) -- III. SORTING OF LYSOSOMAL PROTEINS -- The Mannose-6-Phosphate Receptors (MPRs) -- Sortilin -- Adaptor Proteins - Overview -- Adaptor Proteins - Anterograde Transport -- Adaptor Proteins - Retrograde Transport -- IV. PROSAPOSIN TRAFFICKING -- Overview -- Sortilin-Mediated Sorting of Prosaposin -- Prosaposin Processing in the Golgi Apparatus -- Effect of Endo H Treatment -- Effect of Brefeldin A (BFA) Treatment -- Effects of Sequential Truncations of the Prosaposin C-Terminus -- V. GM2AP TRAFFICKING -- VI. THE ROLE OF LIPID RAFTS IN LYSOSOMAL TRAFFICKING -- VII. THE SORTILIN MODEL -- Inactivation of the Sortilin Gene -- VIII. SIGNIFICANCE OF THIS STUDY -- REFERENCES -- Chapter 6    GOLGI APPARATUS FUNCTIONS IN MANGANESE HOMEOSTASIS AND DETOXIFICATION -- ABSTRACT -- INTRODUCTION -- METHODS -- Cell Culture -- Treatment and Sample Preparation for Nano-Imaging -- Synchrotron X-Ray Fluorescence Nano-Imaging -- Golgi Apparatus Labeling -- RESULTS -- DISCUSSION -- Manganese Accumulation in GA -- Role of GA in Mn Detoxification -- Manganese Alteration of GA and Neurodegenerative Diseases -- CONCLUSION -- ACKNOWLEDGMENTS -- REFERENCES -- INDEX -- Blank Page."]
[null,null,null,"Sommario/riassunto","The Golgi apparatus is an organelle found in most eukaryotic cells. The primary function of the Golgi apparatus is to process and package macromolecules, such as proteins and lipids, after their synthesis and "]
[{"$nulls":4},"before they make their way to their destination. This book presents topical research data in the study of Golgi apparatus, including Golgi organisation and stress sensing, signalling pathways controlling mitotic Golgi breakdown in mammalian cells, the role of Golgi apparatus in the biological mechanisms of hypericin-mediated photodynamic therapy, the role of the Trans-Golgi Network (TGN) in the sorting of nonenzymic lysosomal proteins, and the mechanisms involving the role of Golgi apparatus alteration in neurological disorders triggered by manganese."]