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[null,"1.","Record Nr.",null,"UNINA9910886988303321"]
[null,null,"Autore",null,"Baker Jillian G"]
[null,null,"Titolo",null,"Adrenoceptors / / edited by Jillian G. Baker, Martin C. Michel, Roger J. Summers"]
[null,null,"Pubbl/distr/stampa",null,"Cham : , : Springer International Publishing : , : Imprint : Springer, , 2024"]
[null,null,"ISBN",null,"3-031-66776-X"]
[null,null,"Edizione",null,"[1st ed. 2024.]"]
[null,null,"Descrizione fisica",null,"1 online resource (691 pages)"]
[null,null,"Collana",null,"Handbook of Experimental Pharmacology, , 1865-0325 ; ; 285"]
[null,null,"Disciplina",null,"615"]
[null,null,"Soggetti",null,"Pharmacology"]
[{"$nulls":4},"Drugs - Design"]
[{"$nulls":4},"Structure-Based Drug Design"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,"Nota di contenuto",null,"Introduction: a short history of adrenoceptor research -- Structures of Adrenoceptors -- Genetic Variants of Adrenoceptors -- Adrenoceptors: Receptors, Ligands and Their Clinical Uses, Molecular Pharmacology and Assays -- Signalling of adrenoceptors: canonical pathways and new paradigms -- Presynaptic Adrenoceptors -- Roles of b-adrenoceptor subtypes and therapeutics in human cardiovascular disease:- heart failure, tachyarrhythmias and other cardiovascular disorders -- Adrenoceptors and Hypertension -- Adrenoceptors in the Lower Urinary Tract -- Asthma and COPD: A Focus on b-Agonists – Past, Present and Future -- Adrenoceptors in the Eye- Physiological and Pathophysiological Relevance -- Adrenoceptors: A Focus on Psychiatric Disorders and Their Treatments -- Locus Coeruleus and Noradrenergic Pharmacology in Neurodegenerative Disease -- Clinical use of adrenergic receptor ligands in acute care settings -- Adrenoceptor expression and function in the endocrine pancreas -- b-adrenoceptors in cancer: old players and new perspectives."]
[null,null,null,"Sommario/riassunto","Adrenoceptors have been at the forefront of physiological and pharmacological research for a century. They served as prototypes for rationale drug design as recognized by a Nobel Prize to Sir James Black and for the molecular understanding and structure of G protein-coupled receptors as recognized by a Nobel Prize to Brian Kobilka and Robert J. Lefkowitz. Drugs directly or indirectly targeting adrenoceptors have become guideline-recommended treatments for more than 30 human and various animal diseases. This volume assembles leading "]
[{"$nulls":4},"experts on various types of adrenoceptor research to provide concise insight into the current standing and future direction of uses of adrenoceptor-targeted drugs and research in this field."]