{"text_format":"2","workbook":"xls","n_sheets":1,"sheets":["report2"],"not_rendered":{"charts":0,"images":0,"macros":0,"external_links":1,"defined_names":1,"comments":0,"pivot_tables":0},"unopened":[],"bounds":{"document_bytes":16777216,"sheet_cells":100000,"run_cost":"one","rows_first":2000,"rows_last":500,"rows_between":2000,"halvings":0,"cell_chars":16384,"cell_head_chars":4096},"cells_cut":0,"cells_raw":0,"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"report2","index":0,"n_rows":21,"n_cols":5,"rows_kept":21,"cut":false,"hidden":false,"merged":[[0,2,0,3],[0,4,0,5],[1,2,1,3],[1,4,1,5],[2,2,2,3],[4,2,4,3],[6,2,6,3],[7,2,7,3],[8,2,8,3],[9,2,9,3],[10,2,10,3],[13,2,13,3]],"flags":["formulas_cached_only"]}
[null,"1.","Record Nr.",null,"UNINA9910831190103321"]
[null,null,"Titolo",null,"Drug and therapy development for triple negative breast cancer / / edited by Pravin Kendrekar, Vinayak Adimule, and Tara Hurst"]
[null,null,"Pubbl/distr/stampa",null,"Weinheim, Germany : , : WILEY-VCH GmbH, , [2023]"]
[{"$nulls":4},"©2023"]
[null,null,"ISBN",null,"3-527-84116-4"]
[{"$nulls":4},"3-527-84118-0"]
[null,null,"Descrizione fisica",null,"1 online resource (323 pages)"]
[null,null,"Disciplina",null,"016.22"]
[null,null,"Soggetti",null,"Breast - Cancer - Treatment"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Nota di bibliografia","Includes bibliographical references and index."]
[null,null,"Nota di contenuto",null,"Intro -- Title Page -- Contents -- Preface -- Part I History of Breast Cancer -- 1 Early-Stage Diagnosis of Breast Cancer: Amelioration in Approaches -- 1.1 Introduction -- 1.2 Imaging Techniques -- 1.2.1 Mammography (MG) -- 1.2.2 Ultrasonography (US) -- 1.2.3 Magnetic Resonance Imaging (MRI) -- 1.3 Microwave Breast Imaging Methods -- 1.3.1 Microwave Tomography -- 1.3.2 Radio-Based Microwave Imaging -- 1.4 Biomarkers and Biosensors for Breast Cancer Detection -- 1.4.1 Biomarkers -- 1.4.2 Biosensors -- 1.5 Conclusion -- Acknowledgment -- Conflict of Interest -- Authors Contribution -- References -- 2 DNA Replication Stress and Genome Instability in Breast Cancer -- 2.1 Introduction -- 2.2 Causes of Replication Stress and Genomic Instability -- 2.2.1 Replication Dysfunction -- 2.2.2 Transcription-Induced Stress -- 2.2.3 Genomic Aberrations and Instability -- 2.3 Molecular Mechanism of Genomic Instability -- 2.3.1 Problems Faced During DNA Damage Repair -- 2.3.2 Transcriptional Stress -- 2.3.3 CIN: Result of Defective Mitosis -- 2.4 Aftermath of Replication Stress on Cell and Its Fate -- 2.4.1 Conservation of Stalled Replication Forks -- 2.4.2 Chromosome Segregation Defect Check by HR Repair -- 2.4.3 Aging, Cell Death, and Senescence -- 2.5 Therapeutic Approach -- 2.6 Conclusion -- Abbreviations -- References -- 3 Recent Advancement of Nanotherapeutics to Treat Breast Cancer -- 3.1 Introduction -- 3.2 Pathophysiology of Breast Cancer -- 3.3 Classification of Breast Cancer -- 3.4 Techniques for Breast Cancer Detection -- 3.5 Current Breast Cancer Therapies -- 3.6 Nanotherapeutics for Breast Cancer Treatment and Metastasis -- 3.6.1 Nanodiamonds (NDs) -- 3.6.2 Intrinsic Toxicity "]
[{"$nulls":4},"Reduction -- 3.6.3 Diminishing Chemoresistance (CR) -- 3.6.4 Delivery of Combination Therapeutics Through NDs -- 3.7 Polymer-Based Nanoparticles (PBNPs)."]
[{"$nulls":4},"3.8 Inorganic Nanoparticles (IONPs) -- 3.9 Hydrogels (HGLs) and Microbubbles (MBs) -- 3.10 Recent Patents of Nanotherapeutics for Breast Cancer Treatment -- 3.11 Clinical Trials of Nanotherapeutics for Breast Cancer -- 3.12 Conclusion and Future Perspectives -- References -- 4 HER Receptor in Breast Cancer -- 4.1 Introduction -- 4.2 Role of HER Receptors in the Human Body -- 4.3 HER2 Receptor in Breast Cancer Progression -- 4.4 Conclusion -- Conflict of Interest -- References -- 5 Human Endogenous Retroviruses in Triple-Negative Breast Cancer -- 5.1 Introduction -- 5.2 HERVs in Breast Cancer and TNBC -- 5.3 TROJAN lncRNA and TNBC -- 5.4 HERVs and Breast Cancer Treatments -- 5.5 Conclusion -- 5.6 Search Strategy -- References -- Part II Novel Drug Discovery and Development -- 6 Development in Drug Repurposing for the Treatment of Acute Leukemia Complicating Metastatic Breast Cancer -- 6.1 Introduction -- 6.1.1 Acute Leukemia's -- 6.1.2 Mitochondrial cAMP-PKA Signaling -- 6.1.3 Nuclear Compartment -- 6.1.4 Cytosolic Compartment and Plasma Membrane -- 6.2 Conclusion -- Conflict of Interest -- References -- 7 Novel Pharmaceutical Nanomaterials to Advance the Current Breast Cancer Treatment - Current Trends and Future Perspective -- 7.1 Introduction -- 7.2 Graphene-Based Nanomaterials for Breast Cancer -- 7.3 Light-Based Nanotechnology for Breast Cancer -- 7.3.1 Photodynamic Therapeutic Nanomaterials -- 7.3.2 Photothermal Therapeutic Nanomaterials -- 7.4 Green Synthesis of Gold Nanoparticles for Breast Cancer -- 7.5 Nanocarriers for Gene Therapy and Immunotherapy -- 7.6 Conclusion and Recommendations -- References -- Part III Advanced Technologies in Breast Cancer Therapy -- 8 Artificial Intelligence-Driven Decisions in Breast Cancer Diagnosis -- 8.1 Introduction -- 8.2 Breast Cancer -- 8.3 Diagnosis of Breast Cancer -- 8.4 Artificial Intelligence."]
[{"$nulls":4},"8.4.1 Artificial Intelligence and Medical Imaging -- 8.5 Conclusion -- 8.6 Future Challenges -- References -- 9 Establishing Nanotechnology-Based Drug Development for Triple-Negative Breast Cancer Treatment -- 9.1 Introduction -- 9.2 Triple-Negative Breast Cancer -- 9.2.1 Molecular Mechanisms (Signaling Pathways) Involved in TNBC Therapeutics -- 9.2.2 Conventional Therapeutics -- 9.2.3 Promising Nanotechnology Innovations for TNBC Therapy -- 9.2.4 Vaccines Under the Clinical Trial (CT) for TNBC Treatment -- 9.2.5 USFDA-Approved Clinical Trials -- 9.2.6 Current Status of TNBC Treatment -- 9.2.7 Recent Patents Based on Nanoformulations for TNBC Treatment -- 9.3 Challenges -- 9.4 Future Perspectives on TNBC Metastasis Therapy -- 9.4.1 NEO Adjuvant Modeling -- 9.4.2 Execution of In Vivo Genetic Screening -- 9.4.3 Identification of Effective Drugs for TNBC -- 9.4.4 Synergistic Effect of Drugs that Almost Eliminate Tumor -- 9.5 Conclusion -- References -- 10 Etiology and Therapy of Hormone Receptor-Positive Breast Cancer -- 10.1 Introduction -- 10.2 Etiology -- 10.2.1 Role of Estrogen Hormone -- 10.2.2 Role of Progesterone Hormone -- 10.2.3 Estrogen Receptor (ER) -- 10.2.4 Progesterone Receptor (PR) -- 10.3 Human Epidermal Growth Factor-2 (HER-2) -- 10.4 Various Types of Breast Cancer Detected Under Hormone Receptor Breast Cancer -- 10.4.1 Estrogen Receptor (ER) Positive -- 10.4.2 Progesterone Receptor (PR) Positive -- 10.4.3 Hormone Receptor (HR) Negative -- 10.5 Detection -- 10.6 Therapy -- 10.6.1 Selective Estrogen-Receptor Response Modulators (SERMs) -- 10.6.2 Aromatase Inhibitors -- 10.6.3 Estrogen-Receptor Down Regulators (ERDs) -- 10.6.4 Luteinizing Hormone-Releasing Hormone "]
[{"$nulls":4},"Agents (LHRH) -- 10.7 Limitations of Hormone Therapy -- 10.7.1 Tamoxifen -- 10.7.2 Raloxifene -- 10.7.3 Aromatase Inhibitors -- 10.7.4 Fulvestrant."]
[{"$nulls":4},"10.8 Triple-Negative Breast Cancer -- 10.8.1 Clinical History of Triple-Negative Breast Cancer -- 10.8.2 Imaging Characteristics/Features of Triple-Negative Breast Cancer -- 10.8.3 Subtypes of TNBC -- 10.8.4 Treatment of Triple-Negative Breast Cancer -- 10.8.5 Advance TNBC -- 10.8.6 Pharmacogenomics -- 10.9 Conclusion -- References -- 11 Donor-Acceptor-Based Heterocyclic Compounds as Chemotherapy and Photothermal Agents in Treatment of Breast Cancer Cell -- 11.1 Introduction -- 11.2 Causes for Breast Cancer -- 11.3 Imaging and Screening of Breast Cancer -- 11.4 Photothermal Therapy (PTT) -- 11.5 Acceptor-Donor-Based Heterocyclic Compounds -- 11.6 Examples of Organic-Based Donor-Acceptor -- 11.6.1 Indocyanine -- 11.7 Polymers-Based Agents -- 11.7.1 Phthalocyanine -- 11.8 Conclusion -- References -- Part IV Regulatory, Clinical Aspects and Case Studies -- 12 An Insight into Drug Regulatory Affairs and the Procedures -- 12.1 Endpoints of Clinical Trials for the Approval of Cancer Drugs and Biologics -- 12.2 Statutory and Regulatory Requirements for Effectiveness -- 12.2.1 Endpoints Supporting Previous Oncology Approvals -- 12.2.2 Endpoints Based on Tumor Assessments -- 12.2.3 Clinical Practice Guideline for the Diagnosis, Staging, and Treatment of Patients with Metastatic Breast Cancer -- 12.2.4 Cancer Drug and Diagnostic Regulation by the FDA -- 12.2.5 Considerations for Clinical Trial Design and Analysis -- 12.2.6 Single-Arm Studies -- 12.2.7 Randomized Studies Designed to Demonstrate Noninferiority -- 12.3 Clinical Trial Design Considerations -- 12.4 Clinical Trial Analysis Issues -- 12.5 Use of Pathological Complete Response as an Endpoint to Support Accelerated Approval in Neoadjuvant Treatment of High-Risk Early-Stage Breast Cancer -- 12.6 Developing Treatments for Premenopausal Women with Breast Cancer -- 12.7 Recommendations by FDA."]
[{"$nulls":4},"12.7.1 Access to Experimental Cancer Drugs -- 12.7.2 How to Get a Hold of an Experimental Drug -- 12.7.3 Access to More Information (Compassionate Use) -- 12.8 What is Right to Try? -- 12.9 Examples of Drugs Approved for Breast Cancer -- References -- 13 A Comprehensive Review of Some Heat-Shock Proteins in the Development and Progression of Human Breast Cancer -- 13.1 Introduction -- 13.1.1 Cancer and Its Economic Burden on Human -- 13.2 Structure-Functional Features of HSPs -- 13.2.1 Heat-Shock Protein 40 -- 13.2.2 Heat-Shock Protein 60 -- 13.2.3 Heat-Shock Protein 70 -- 13.2.4 Heat-Shock Protein 90 -- 13.3 Conclusion and Future Perspectives -- Acknowledgments -- References -- 14 Nanoparticle-Based Therapeutics for Triple Negative Breast Cancer -- 14.1 Breast Cancer: State of Research and Practice -- 14.2 Triple Negative Breast Cancer (TNBC) and Treatment Approaches -- 14.3 Nanoparticle Therapeutics for TNBC -- 14.3.1 Metallic Nanoparticles -- 14.3.2 Dendrimers -- 14.3.3 Lipid-Based Nanoparticles (LNPs) -- 14.3.4 CRISPR Nanoparticles -- 14.3.5 Exosomes (Exo) -- 14.3.6 Nucleic Acid (NA)-Based Therapeutics -- 14.4 Ligands Used to Enhance Nanoparticle Therapeutics in TNBC -- 14.4.1 Antibodies -- 14.4.2 Peptides -- 14.4.3 Aptamers -- 14.4.4 Small Molecules -- 14.5 Conclusion -- References -- 15 Current Updates in Breast Cancer Drugs -- 15.1 Introduction -- 15.2 Therapeutic Approaches -- 15.2.1 Hormonotherapy -- 15.2.2 Chemotherapy -- 15.3 Targeted Therapy -- 15.3.1 Drug Repurposing -- 15.3.2 HER2 Inhibitors -- 15.3.3 PARP Inhibitors -- 15.3.4 Immunotherapy -- 15.3.5 Others Novel Targets -- 15.4 Conclusion -- Acknowledgment -- Conflict of Interest -- Authors "]
[{"$nulls":4},"Contribution -- References -- Index -- EULA."]