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[null,"1.","Record Nr.",null,"UNINA9910830560303321"]
[null,null,"Titolo",null,"Computer applications in pharmaceutical research and development [[electronic resource] /] / [edited by] Sean Ekins"]
[null,null,"Pubbl/distr/stampa",null,"Hoboken, N.J., : Wiley-Interscience, c2006"]
[null,null,"ISBN",null,"1-280-46840-8"]
[{"$nulls":4},"9786610468409"]
[{"$nulls":4},"0-470-03723-7"]
[{"$nulls":4},"0-470-03722-9"]
[null,null,"Descrizione fisica",null,"1 online resource (840 p.)"]
[null,null,"Collana",null,"Wiley series in drug discovery and development"]
[null,null,"Disciplina",null,"615.0285"]
[{"$nulls":4},"615/.10285"]
[null,null,"Soggetti",null,"Pharmacy - Data processing"]
[{"$nulls":4},"Pharmacology - Data processing"]
[{"$nulls":4},"Pharmaceutical industry - Data processing"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references and index."]
[null,null,"Nota di contenuto",null,"The history of computers in pharmaceutical research and development: a narrative / Donald B. Boyd and Max M. Marsh -- Computers as data analysis and data management tools in preclinical development / Weiyong Li and Kenneth Banks -- Statistical modeling in pharmaceutical research and development / Andrea de Gaetano ... [et al.] -- Drug discovery from historic herbal texts / Eric J. Buenz -- Contextualizing the impact of bioinformatics on preclinical drug and vaccine discovery / Darren R. Flower -- Systems approaches for pharmaceutical research and development / Sean Ekins and Craig Giroux -- Information management-biodata in life sciences / Richard K. Scott and Anthony Parsons -- Chemoinformatics techniques for processing chemical structure databases / Valerie J. Gillet and Peter Willett -- Electronic laboratory notebooks / Alfred Nehme and Robert A. Scoffin -- Strategies for using information effectively in early-stage drug discovery / David J. Wild -- Improving the pharmaceutical R&D process: how simulation can support management decision making / Andrew Chadwick ... [et al.] --"]
[{"$nulls":4},"Computers and protein crystallography / David J. Edwards and Roderick E. Hubbard -- Computers, cheminformatics, and the medicinal chemist / Weifan Zheng and Michael Jones -- The challenges of making useful "]
[{"$nulls":4},"protein-ligand free energy predictions for drug discovery / Jun Shimada -- Computer algorithms for selecting molecule libraries for synthesis / Konstantin V. Balakin, Nikolay P. Savchuk, and Alex Kiselyov -- Success stories of computer-aided design / Hugo Kubinyi -- Pharmaceutical research and development productivity: can software help? / Christophe Lambert and S. Stanley Young -- Computer methods for predicting drug metabolism / Sean Ekins -- Computers in toxicology and risk assessment / John C. Dearden -- Computational modeling of drug disposition / Cheng Chang and Peter W. Swaan -- Computer simulations in pharmacokinetics and pharmacodynamics: rediscovering systems physiology in the 21st century / Paolo Vicini -- Predictive models for better decisions from understanding physiology to optimizing trial design / James R. Bosley, Jr --"]
[{"$nulls":4},"Making pharmaceutical development more efficient / Michael Rosenberg and Richard Farris -- Use of interactive software in medical decision making / Renée J. Goldberg Arnold -- Clinical data collection and management / Mazen Abdellatif -- Regulation of computer systems / Sandy Weinberg -- A new paradigm for analyzing adverse drug events / Ana Szarfman, Jonathan G. Levine and Joseph M. Tonning -- Computers in pharmaceutical formulation / Raymond C. Rowe and Elizabeth A. Colbourn -- Legal protection of innovative uses of computers in R&D / Robert Harrison -- The ethics of computing in pharmaceutical research / Matthew K. McGowan and Richard J. McGowan -- The UltraLink: an expert system for contextual hyperlinking in knowledge management / Martin Romacker ... [et al.] -- Powerful, predictive and pervasive: the future of computers in the pharmaceutical industry / Nick Davies, Heather Ahlborn, Stuart Henderson."]
[null,null,null,"Sommario/riassunto","A unique, holistic approach covering all functions and phases of pharmaceutical research and developmentWhile there are a number of texts dedicated to individual aspects of pharmaceutical research and development, this unique contributed work takes a holistic and integrative approach to the use of computers in all phases of drug discovery, development, and marketing. It explains how applications are used at various stages, including bioinformatics, data mining, predicting human response to drugs, and high-throughput screening. By providing a comprehensive view, the book offers read"]
[null,"2.","Record Nr.",null,"UNINA9910903789103321"]
[null,null,"Autore",null,"Rudnicki Ryszard"]
[null,null,"Titolo",null,"Individual-Based Models and Their Limits / / by Ryszard Rudnicki, Radosław Wieczorek"]
[null,null,"Pubbl/distr/stampa",null,"Cham : , : Springer Nature Switzerland : , : Imprint : Springer, , 2024"]
[null,null,"ISBN",null,"3-031-75270-8"]
[null,null,"Edizione",null,"[1st ed. 2024.]"]
[null,null,"Descrizione fisica",null,"1 online resource (VIII, 126 p. 12 illus.)"]
[null,null,"Collana",null,"SpringerBriefs in Mathematical Methods, , 2365-0834"]
[null,null,"Disciplina",null,"519"]
[null,null,"Soggetti",null,"Mathematics"]
[{"$nulls":4},"Biomathematics"]
[{"$nulls":4},"Applications of Mathematics"]
[{"$nulls":4},"Mathematical and Computational Biology"]
[{"$nulls":4},"Biologia de poblacions"]
[{"$nulls":4},"Models matemàtics"]
[{"$nulls":4},"Llibres electrònics"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,"Nota di contenuto",null,"- 1. Models -- 2. Limit Passages -- 3. Central Limit-type Theorems -- 4. Selected Superprocesses -- 5. Phenotype Models -- 6. Modelling of Phytoplankton Dynamics -- 7. Chemotaxis Models."]
[null,null,null,"Sommario/riassunto","Individual-based models (IBM) describe a population as a collection of different organisms whose local interactions determine the behaviour of the entire population. The individual description is convenient for computer simulations and the determination of various model parameters, and appropriate limit passages lead to the transport equations used in classical population dynamics models. The aim of this book is to provide a brief mathematical introduction to IBMs and their application to selected biological topics. The book is divided into seven chapters. In the first chapter we give a general description of IBMs and we present examples of models to illustrate their possible applications. Examples of applications include age, size and phenotype models, coagulation-fragmentation process, and models of genome evolution. The second chapter contains some theoretical results concerning limit passages from IBMs to phenotype and age-structured models. The rate of this convergence formulated as functional central limit theorems is presented in Chapter 3. As a result of the limit passage can be a superprocess, i.e., a stochastic process with values in "]
[{"$nulls":4},"a space of measures. Chapter 4 presented examples of such passages: from the branching Brownian motion to the Dawson--Watanabe superprocess and from the Moran's model of genetic drift with mutations to the Fleming--Viot superprocess. The next three chapters are devoted to models, in which we directly participated in the study. In Chapter 5 we study IBMs phenotype models and their limit passages. We show that random mating stabilises the distribution of traits, while assortative mating can lead to a polymorphic population. Formation of aggregates of phytoplankton and their movement is studied in Chapter 6. We present two types of models based on: fragmentation-coagulation processes; and diffusion with chemical signals leading to advanced superprocesses. Chapter 7 is devoted to rather advanced models with chemotaxis used to description of retinal angiogenesis and cell proliferations. The book is complemented by two appendices in which we have collected information about stochastic processes and various spaces we have used. The book is dedicated both to mathematicians and biologists. The first group will find here new biological models which leads to interesting and often new mathematical questions. Biologists can observe how to include seemingly different biological processes into a unified mathematical theory and deduce from this theory interesting biological conclusions. Apart from the sections on superprocesses, where quite advanced mathematical issues arise, such as stochastic partial equations, we try to keep the required mathematical and biological background to a minimum so that the topics are accessible to students."]