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[null,"1.","Record Nr.",null,"UNINA9910830425203321"]
[null,null,"Titolo",null,"Glycogen synthase kinase 3 (GSK-3) and its inhibitors [[electronic resource] ] : drug discovery and development / / edited by Ana Martinez, Ana Castro, Miguel Medina"]
[null,null,"Pubbl/distr/stampa",null,"Hoboken, N.J., : Wiley-Interscience, c2006"]
[null,null,"ISBN",null,"1-280-64906-2"]
[{"$nulls":4},"9786610649068"]
[{"$nulls":4},"0-470-05217-1"]
[{"$nulls":4},"0-470-05215-5"]
[null,null,"Descrizione fisica",null,"1 online resource (388 p.)"]
[null,null,"Collana",null,"Wiley series in drug discovery and development"]
[null,null,"Disciplina",null,"547.12"]
[{"$nulls":4},"572.567"]
[{"$nulls":4},"572/.567"]
[null,null,"Soggetti",null,"Glycogen synthase kinase-3"]
[{"$nulls":4},"Glycogen synthase kinase-3 - Inhibitors"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references and index."]
[null,null,"Nota di contenuto",null,"Glycogen synthase kinase 3: an introductory synopsis -- Glycogen synthase kinase-3[beta] (GSK-3[beta]) a key signaling enzyme: a developmental neurobiological perspective -- Role of GSK-3/Shaggy in neuronal cell biology -- The crystal structures of glycogen synthase kinase 3 -- Kinase-kinase and site-site interactions in the phosphorylation of tau by GSK-3 -- GSK-3, a key player in Alzheimer's disease -- Glycogen synthase kinase 3 : a target for novel mood disorder treatments -- GSK-3 and stem cells -- Glycogen synthase kinase 3 : role in neurodegeneration and neuroprotection --"]
[{"$nulls":4},"Protein kinase assays for drug discovery -- Animal models with modified expression of GSK-3 for the study of its physiology and of its implications in human pathologies -- Lithium, the seminal GSK-3 inhibitor -- Inhibition of GSK-3 as therapeutic strategy in disease : efficacy of AR-A014418 -- TDZD's: selective and ATP noncompetitive glycogen synthase kinase 3 inhibitors -- 3-amino pyrazoles as potent and selective glycogen kinase synthase (GSK-3) inhibitors -- Marine compounds as a new source for glycogen synthase kinase 3 inhibitors."]
[null,null,null,"Sommario/riassunto","Many researchers believe that GSK-3 and its inhibitors could lead to effective treatments for neurogenerative disorders, type II diabetes, "]
[{"$nulls":4},"depression and bipolar disorder, and some forms of cancer. This book provides a thorough introduction to GSK-3, presents up-to-date information, and mentions the birth of several chemical families of GSK-3 inhibitors with varying selectivity. It's a great reference for researchers in drug design and development."]