{"text_format":"2","workbook":"xls","n_sheets":1,"sheets":["report2"],"not_rendered":{"charts":0,"images":0,"macros":0,"external_links":1,"defined_names":1,"comments":0,"pivot_tables":0},"unopened":[],"bounds":{"document_bytes":16777216,"sheet_cells":100000,"run_cost":"one","rows_first":2000,"rows_last":500,"rows_between":2000,"halvings":0,"cell_chars":16384,"cell_head_chars":4096},"cells_cut":0,"cells_raw":0,"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"report2","index":0,"n_rows":14,"n_cols":5,"rows_kept":14,"cut":false,"hidden":false,"merged":[[0,2,0,3],[0,4,0,5],[1,2,1,3],[1,4,1,5],[2,2,2,3],[2,4,2,5],[3,2,3,3],[4,2,4,3],[5,2,5,3],[6,2,6,3],[7,2,7,3],[8,2,8,3],[9,2,9,3],[12,2,12,3]],"flags":["formulas_cached_only"]}
[null,"1.","Record Nr.",null,"UNINA9910829923103321"]
[null,null,"Autore",null,"Mountain A"]
[null,null,"Titolo",null,"Biotechnology, Recombinant Proteins, Monoclonal Antibodies, and Therapeutic Genes. Vol. 5"]
[null,null,"Pubbl/distr/stampa",null,"[Place of publication not identified], : Wiley VCH Imprint, 1999"]
[null,null,"ISBN",null,"3-527-62086-9"]
[null,null,"Descrizione fisica",null,"1 online resource (xvi, 562 pages) : illustrations"]
[null,null,"Disciplina",null,"660.6"]
[null,null,"Soggetti",null,"Biotechnology"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Bibliographic Level Mode of Issuance: Monograph"]
[null,null,"Nota di contenuto",null,"Types and Function of Proteins -- Sequence and Structure of Proteins -- Protein Interactions -- In vitro Folding of Inclusion Body Proteins on an Industrial Scale -- Medical Applications of Recombinant Proteins in Humans and Animals -- Enzymes for Industrial Applications -- Antibody Engineering and Expression -- Manufacture of Therapeutic Antibodies -- Use of Antibodies for Immunopurification -- Preclinical Testing of Antibodies: Pharmacology, Kinetics and Immunogenicity -- Preclinical Testing of Antibodies : Safety Aspects -- Therapeutic Applications of Monoclonal Antibodies : A Clinical Overview -- Antibodies for Sepsis: Some Lessons Learnt -- An Engineered Human Antibody for Chronic Therapy : CDP571 -- Antibody Targeted Chemotherapy -- ReoPro Clinical Development : A Case Study -- Overview of Gene Therapy -- Viral Vectors for Gene Therapy -- Non-Viral Vectors for Gene Therapy -- Issues of Large-Scale Plasmid DNA Manufacturing -- Gene Therapy for HIV Infection -- Regulation of Antibodies and Recombinant Proteins -- Regulation of Human Gene Therapy -- Economic Considerations."]
[null,null,null,"Sommario/riassunto","In the field of medicinal biotechnology three major developments have caused a revolution in research that has a lot of innovative effects on clinical medicine and future applications on humans. With the availability of tailored recombinant proteins and the opportunity to produce high amounts of monoclonal antibodies new diagnostic applications have emerged and many therapeutic perspectives, e.g. in the treatment of multiple sclerosis and of cancer, are being discussed today."]