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[null,"1.","Record Nr.",null,"UNINA9910824035203321"]
[null,null,"Titolo",null,"Metal-carbon bonds in enzymes and cofactors / / edited by Astrid Sigel, Helmut Sigel, and Roland K.O. Sigel"]
[null,null,"Pubbl/distr/stampa",null,"Cambridge, UK : , : RSC Publishing, , 2009"]
[null,null,"ISBN",null,"3-11-043658-2"]
[null,null,"Descrizione fisica",null,"1 online resource"]
[null,null,"Collana",null,"Metal ions in life sciences, , 1559-0836 ; ; volume 6"]
[null,null,"Disciplina",null,"572.7"]
[null,null,"Soggetti",null,"Metalloenzymes"]
[{"$nulls":4},"Coenzymes"]
[{"$nulls":4},"Organometallic compounds"]
[{"$nulls":4},"Vitamin B12"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Nota di bibliografia","Includes bibliographical references and indexes."]
[null,null,"Nota di contenuto",null,"Organometallic chemistry of B12 coenzymes -- Cobalamin- and corrinoid-dependent enzymes -- Nickel-alkyl bond formation in the active site of methyl-coenzyme M reductase -- Nickel-carbon bonds in acetyl-coenzyme a synthases/carbon monoxide dehydrogenases -- Structure and function of [NiFe]-hydro-genases -- Carbon monoxide and cyanide ligands in the active site of [FeFe]-hydrogenases -- Carbon monoxide as intrinsic ligand to iron in the active site of [Fe]-hydrogenase -- Dual role of heme as cofactor and substrate in the biosynthesis of carbon monoxide -- Copper-carbon bonds in mechanistic and structural probing of proteins as well as in situations where copper is a catalytic or receptor site -- Interaction of cyanide with enzymes containing vanadium, manganese, non-heme iron, and zinc -- Reaction mechanism of the molybdenum hydroxylase xanthine oxidoreductase: evidence against the formation of intermediates having metal-carbon bonds."]
[null,null,null,"Sommario/riassunto","The occurrence of a wide variety of metal-carbon bonds in living organisms, ranging from bacteria to humans, is only recently recognized. Of course, the historical examples are the B12 coenzymes containing cobalt-carbon bonds, but now such bonds are also known for nickel, iron, copper, and other transition metal ions. There is no other comparable book; MILS-6, written by 17 experts, summarizes the most recent insights into this fascinating topic."]