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[null,"1.","Record Nr.",null,"UNINA9910830637803321"]
[null,null,"Autore",null,"McLachlan Geoffrey J. <1946->"]
[null,null,"Titolo",null,"Analyzing microarray gene expression data [[electronic resource] /] / Geoffrey J. McLachlan, Kim-Anh Do, Christopher Ambroise"]
[null,null,"Pubbl/distr/stampa",null,"Hoboken, N.J., : Wiley-Interscience, c2004"]
[null,null,"ISBN",null,"1-280-25332-0"]
[{"$nulls":4},"9786610253326"]
[{"$nulls":4},"0-470-35030-X"]
[{"$nulls":4},"0-471-72612-5"]
[{"$nulls":4},"0-471-72842-X"]
[null,null,"Descrizione fisica",null,"1 online resource (366 p.)"]
[null,null,"Collana",null,"Wiley series in probability and statistics"]
[null,null,"Disciplina",null,"572.8636"]
[{"$nulls":4},"572.865"]
[null,null,"Soggetti",null,"DNA microarrays - Statistical methods"]
[{"$nulls":4},"Gene expression - Statistical methods"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references and index."]
[null,null,"Nota di contenuto",null,"Analyzing Microarray Gene Expression Data; Contents; Preface; 1 Microarrays in Gene Expression Studies; 1.1 Introduction; 1.2 Background Biology; 1.2.1 Genome, Genotype, and Gene Expression; 1.2.2 Of Wild-Types and Other Alleles; 1.2.3 Aspects of Underlying Biology and Physiochemistry; 1.3 Polymerase Chain Reaction; 1.4 cDNA; 1.4.1 Expressed Sequence Tag; 1.5 Microarray Technology and Application; 1.5.1 History of Microarray Development; 1.5.2 Tools of Microarray Technology; 1.5.3 Limitations of Microarray Technology; 1.5.4 Oligonucleotides versus cDNA Arrays"]
[{"$nulls":4},"1.5.5 SAGE: Another Method for Detecting and Measuring Gene Expression Levels1.5.6 Emerging Technologies; 1.6 Sampling of Relevant Research Entities and Public Resources; 2 Cleaning and Normalization; 2.1 Introduction; 2.2 Cleaning Procedures; 2.2.1 Image Processing to Extract Information; 2.2.2 Missing Value Estimation; 2.2.3 Sources of Nonlinearity; 2.3 Normalization and Plotting Procedures for Oligonucleotide Arrays; 2.3.1 Global Approaches for Oligonucleotide Array Data; 2.3.2 Spiked Standard Approaches; 2.3.3 Geometric Mean and Linear Regression Normalization for Multiple Arrays"]
[{"$nulls":4},"2.3.4 Nonlinear Normalization for Multiple Arrays Using Smooth Curves2.4 Normalization Methods for cDNA Microarray Data; 2.4.1 "]
[{"$nulls":4},"Single-Array Normalization; 2.4.2 Multiple Slides Normalization; 2.4.3 ANOVA and Related Methods for Normalization; 2.4.4 Mixed-Model Method for Normalization; 2.4.5 SNOMAD; 2.5 Transformations and Replication; 2.5.1 Importance of Replication; 2.5.2 Transformations; 2.6 Analysis of the Alon Data Set; 2.7 Comparison of Normalization Strategies and Discussion; 3 Some Cluster Analysis Methods; 3.1 Introduction; 3.2 Reduction in the Dimension of the Feature Space"]
[{"$nulls":4},"3.3 Cluster Analysis3.4 Some Hierarchical Agglomerative Techniques; 3.5 k-Means Clustering; 3.6 Cluster Analysis with No A Priori Metric; 3.7 Clustering via Finite Mixture Models; 3.7.1 Definition; 3.7.2 Advantages of Model-Based Clustering; 3.8 Fitting Mixture Models Via the EM Algorithm; 3.8.1 E-Step; 3.8.2 M-Step; 3.8.3 Choice of Starting Values for the EM Algorithm; 3.9 Clustering Via Normal Mixtures; 3.9.1 Heteroscedastic Components; 3.9.2 Homoscedastic Components; 3.9.3 Spherical Components; 3.9.4 Choice of Root; 3.9.5 Available Software; 3.10 Mixtures of t Distributions"]
[{"$nulls":4},"3.11 Mixtures of Factor Analyzers3.12 Choice of Clustering Solution; 3.13 Classification ML Approach; 3.14 Mixture Models for Clinical and Microarray Data; 3.14.1 Unconditional Approach; 3.14.2 Conditional Approach; 3.15 Choice of the Number of Components in a Mixture Model; 3.15.1 Order of a Mixture Model; 3.15.2 Approaches for Assessing Mixture Order; 3.15.3 Bayesian Information Criterion; 3.15.4 Integrated Classification Likelihood Criterion; 3.16 Resampling Approach; 3.17 Other Resampling Approaches for Number of Clusters; 3.17.1 The Gap Statistic"]
[{"$nulls":4},"3.17.2 The Clest Method for the Number of Clusters"]
[null,null,null,"Sommario/riassunto","A multi-discipline, hands-on guide to microarray analysis of biological processes Analyzing Microarray Gene Expression Data provides a comprehensive review of available methodologies for the analysis of data derived from the latest DNA microarray technologies. Designed for biostatisticians entering the field of microarray analysis as well as biologists seeking to more effectively analyze their own experimental data, the text features a unique interdisciplinary approach and a combined academic and practical perspective that offers readers the most complete and applied coverage of the subject"]
[null,"2.","Record Nr.",null,"UNISA996218266003316"]
[null,null,"Autore",null,"Lewalski Barbara Kiefer <1931->"]
[null,null,"Titolo",null,"The life of John Milton [[electronic resource] ] : a critical biography / / Barbara K. Lewalski"]
[null,null,"Pubbl/distr/stampa",null,"Oxford ; ; Malden, MA, : Blackwell Publishers, 2000"]
[null,null,"ISBN",null,"1-281-31076-X"]
[{"$nulls":4},"9786611310769"]
[{"$nulls":4},"0-470-77567-X"]
[{"$nulls":4},"0-470-77684-6"]
[null,null,"Edizione",null,"[1st ed.]"]
[null,null,"Descrizione fisica",null,"1 online resource (814 p.)"]
[null,null,"Collana",null,"Blackwell critical biographies"]
[null,null,"Disciplina",null,"821/.4"]
[{"$nulls":4},"B"]
[null,null,"Soggetti",null,"Poets, English - Early modern, 1500-1700"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references (p. [705]-753) and index."]
[null,null,"Nota di contenuto",null,"The Life of John Milton: A Critical Biography Revised Edition; Contents; List of Plates; Preface; Acknowledgments; List of Abbreviations; 1 \"The Childhood Shews the Man\" 1608-1625; 2 \"To Cambridge . . . for Seven Years\" 1625-1632; 3 \"Studious Retirement\": Hammersmith and Horton 1632-1638; 4 \"I Became Desirous . . . of Seeing Foreign Parts, Especially Italy\" 1638-1639; 5 \"All Mouths Were Opened Against . . . the Bishops\" 1639-1642; 6 \"Domestic or Personal Liberty\" 1642-1645; 7 \"Service . . . Between Private Walls\" 1645-1649"]
[{"$nulls":4},"8 \"The So-called Council of State . . . Desired to Employ My Services\" 1649-16529 \"Tireless . . . for the Sake of Liberty\" 1652-1654; 10 \"I . . . Still Bear Up and Steer Right Onward\" 1654-1658; 11 \"The Last Words of Our Expiring Libertie\" 1658-1660; 12 \"In Darknes, and with Dangers Compast Round\" 1660-1665; 13 \"Higher Argument\": Completing and Publishing Paradise Lost 1665-1669; 14 \"To Try, and Teach the Erring Soul\" 1669-1674; Epilogue: \"Something . . . Written to Aftertimes\"; Notes; Select Bibliography; Index"]
[null,null,null,"Sommario/riassunto","Providing a close examination of Milton's wide-ranging prose and poetry at each stage of his life, Barbara Lewalski reveals a rather different Milton from that in earlier accounts. Provides a close analysis of each of Milton's prose and poetry works. Reveals how Milton was the first writer to self consciously construct himself as an 'author'. Focuses on the development of Milton's ideas and his art."]
[null,"3.","Record Nr.",null,"UNINA9910822436203321"]
[null,null,"Autore",null,"Sholl David S"]
[null,null,"Titolo",null,"Density functional theory : a practical introduction / / David S. Sholl and Jan Steckel"]
[null,null,"Pubbl/distr/stampa",null,"Hoboken, N.J., : Wiley, c2009"]
[null,null,"ISBN",null,"1-118-21104-9"]
[{"$nulls":4},"1-282-13728-X"]
[{"$nulls":4},"9786612137280"]
[{"$nulls":4},"0-470-44771-0"]
[{"$nulls":4},"0-470-44770-2"]
[null,null,"Edizione",null,"[1st ed.]"]
[null,null,"Descrizione fisica",null,"1 online resource (252 p.)"]
[null,null,"Classificazione",null,"UL 2000"]
[{"$nulls":4},"VE 5650"]
[null,null,"Disciplina",null,"530.14/4"]
[null,null,"Soggetti",null,"Density functionals"]
[{"$nulls":4},"Mathematical physics"]
[{"$nulls":4},"Quantum chemistry"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Includes index."]
[null,null,"Nota di contenuto",null,"DENSITY FUNCTIONAL THEORY; CONTENTS; Preface; 1 What Is Density Functional Theory?; 1.1 How to Approach This Book; 1.2 Examples of DFT in Action; 1.2.1 Ammonia Synthesis by Heterogeneous Catalysis; 1.2.2 Embrittlement of Metals by Trace Impurities; 1.2.3 Materials Properties for Modeling Planetary Formation; 1.3 The Schrödinger Equation; 1.4 Density Functional Theory-From Wave Functions to Electron Density; 1.5 Exchange-Correlation Functional; 1.6 The Quantum Chemistry Tourist; 1.6.1 Localized and Spatially Extended Functions; 1.6.2 Wave-Function-Based Methods; 1.6.3 Hartree-Fock Method"]
[{"$nulls":4},"1.6.4 Beyond Hartree-Fock1.7 What Can DFT Not Do?; 1.8 Density Functional Theory in Other Fields; 1.9 How to Approach This Book (Revisited); References; Further Reading; 2 DFT Calculations for Simple Solids; 2.1 Periodic Structures, Supercells, and Lattice Parameters; 2.2 Face-Centered Cubic Materials; 2.3 Hexagonal Close-Packed Materials; 2.4 Crystal Structure Prediction; 2.5 Phase Transformations; Exercises; Further Reading; Appendix Calculation Details; 3 Nuts and Bolts of DFT Calculations; 3.1 Reciprocal Space and k Points; 3.1.1 Plane Waves and the Brillouin Zone"]
[{"$nulls":4},"3.1.2 Integrals in k Space3.1.3 Choosing k Points in the Brillouin Zone; 3.1.4 Metals-Special Cases in k Space; 3.1.5 Summary of k Space; 3.2 Energy Cutoffs; 3.2.1 Pseudopotentials; 3.3 Numerical Optimization; 3.3.1 Optimization in One Dimension; 3.3.2 Optimization in More than One Dimension; 3.3.3 What Do I Really Need to Know about Optimization?; 3.4 DFT Total Energies-An Iterative Optimization Problem; 3.5 Geometry Optimization; 3.5.1 Internal Degrees of Freedom; 3.5.2 Geometry Optimization with Constrained Atoms; 3.5.3 Optimizing Supercell Volume and Shape; Exercises; References"]
[{"$nulls":4},"Further ReadingAppendix Calculation Details; 4 DFT Calculations for Surfaces of Solids; 4.1 Importance of Surfaces; 4.2 Periodic Boundary Conditions and Slab Models; 4.3 Choosing k Points for Surface Calculations; 4.4 Classification of Surfaces by Miller Indices; 4.5 Surface Relaxation; 4.6 Calculation of Surface Energies; 4.7 Symmetric and Asymmetric Slab Models; 4.8 Surface Reconstruction; 4.9 Adsorbates on Surfaces; 4.9.1 Accuracy of Adsorption Energies; 4.10 Effects of Surface Coverage; Exercises; References; Further Reading; Appendix Calculation Details"]
[{"$nulls":4},"5 DFT Calculations of Vibrational Frequencies5.1 Isolated Molecules; 5.2 Vibrations of a Collection of Atoms; 5.3 Molecules on Surfaces; 5.4 Zero-Point Energies; 5.5 Phonons and Delocalized Modes; Exercises; Reference; Further Reading; Appendix Calculation Details; 6 Calculating Rates of Chemical Processes Using Transition State Theory; 6.1 One-Dimensional Example; 6.2 Multidimensional Transition State Theory; 6.3 Finding Transition States; 6.3.1 Elastic Band Method; 6.3.2 Nudged Elastic Band Method; 6.3.3 Initializing NEB Calculations; 6.4 Finding the Right Transition States"]
[{"$nulls":4},"6.5 Connecting Individual Rates to Overall Dynamics"]
[null,null,null,"Sommario/riassunto","Demonstrates how anyone in math, science, and engineering can master DFT calculations Density functional theory (DFT) is one of the most frequently used computational tools for studying and predicting the properties of isolated molecules, bulk solids, and material interfaces, including surfaces. Although the theoretical underpinnings of DFT are quite complicated, this book demonstrates that the basic concepts underlying the calculations are simple enough to be understood by anyone with a background in chemistry, physics, engineering, or mathematics. The authors show how the widespread"]