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[null,"1.","Record Nr.",null,"UNINA9910822397703321"]
[null,null,"Autore",null,"Crichton Robert R"]
[null,null,"Titolo",null,"Metal-based neurodegeneration : from molecular mechanisms to therapeutic strategies / / Robert Crichton and Roberta Ward"]
[null,null,"Pubbl/distr/stampa",null,"Chichester, West Sussex, U.K. : , : Wiley, , 2014"]
[null,null,"ISBN",null,"1-118-55351-9"]
[{"$nulls":4},"1-118-55348-9"]
[{"$nulls":4},"1-118-55349-7"]
[null,null,"Edizione",null,"[Second edition.]"]
[null,null,"Descrizione fisica",null,"1 online resource (439 p.)"]
[null,null,"Disciplina",null,"616.8/0471"]
[null,null,"Soggetti",null,"Brain - Pathophysiology"]
[{"$nulls":4},"Metals - Health aspects"]
[{"$nulls":4},"Nervous system - Degeneration - Etiology"]
[{"$nulls":4},"Oxidative stress"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references and index."]
[null,null,"Nota di contenuto",null,"Brain function, physiology, and the blood-brain barrier -- Role of metal ions in brain function, metal transport, storage, and homeostasis -- Immune system and neuroinflammation -- Oxidative stress in neurodegenerative diseases -- Aging and mild cognitive impairment, MCI -- Parkinson's disease -- Alzheimer's disease -- Huntington's disease and polyglutamine expansion neurodegenerative diseases -- Friedreich's ataxia and diseases associated with expansion of non-coding triplets -- Creutzfeldt-Jakob and other prion diseases -- Amyotropic lateral sclerosis -- Alcoholic brain damage -- Other neurological diseases -- Therapeutic strategies to combat the onset and progression of neurological diseases."]
[null,null,null,"Sommario/riassunto","Neurodegenerative diseases of the human brain appear in various forms, resulting in disorders of movement and coordination, cognitive deterioration and psychiatric disturbances. Many of the key factors leading to neurodegenerative diseases are similar, including the dysfunction of metal ion homeostasis, redox-active metal ions generating oxidative stress, and intracellular inclusion bodies.  Metal-based Neurodegeneration presents a detailed survey of the molecular origins of neurodegenerative diseases. Each chapter is dedicated to a specific disease, presenting the latest scient"]