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[null,"1.","Record Nr.",null,"UNINA9910820979003321"]
[null,null,"Titolo",null,"Advanced vaccine research : methods for the decade of vaccines / / edited by Fabio Bagnoli and Rino Rappuoli"]
[null,null,"Pubbl/distr/stampa",null,"Norfolk, England : , : Caister Academic Press, , [2015]"]
[{"$nulls":4},"©2015"]
[null,null,"ISBN",null,"1-910190-04-7"]
[null,null,"Descrizione fisica",null,"1 online resource (474 p.)"]
[null,null,"Disciplina",null,"615.372"]
[null,null,"Soggetti",null,"Vaccines - Research"]
[{"$nulls":4},"Drug development"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references and index."]
[null,null,"Nota di contenuto",null,"Contents; Contributors; Current Books of Interest; Preface; Part I: Innovative Technologies and Approaches in Vaccine Research; 1: Deep Sequencing in Vaccine Research, Development and Surveillance ; Impact of DNA sequencing on vaccines research and development; Deep sequencing potential to transform vaccinology; 2: New Bioinformatics Algorithms Applied to Deep Sequencing Projects ; Introduction; Better understating of host and pathogen genomes; Computational approaches to study adaptive immune responses; Better understanding of transcriptome"]
[{"$nulls":4},"Epigenomics: understanding of inheritable chemical changesMetagenomics: finding new pathogens and strains; Bioinformatics challenges; 3: Comparative Genomics Approaches for Tracking the Emergence and Spread of Disease-associated Bacteria; Background; Comparative genomics of disease-associated bacteria; Assays for identification of disease-associated bacteria based on insights from comparative genomics; Conclusions; 4: Quantitative Proteomics in Vaccine Research; Introduction; Quantitative proteomics based on gel electrophoresis; Quantitative proteomics based on differential mass tag"]
[{"$nulls":4},"Label-free technologies and targeted proteomicsMass spectrometry for viral vaccinology; Proteomic technology for vaccine development ; Combining proteomics and system biology to improve vaccines; Concluding remarks; 5: Structural Biology in Vaccine Research; Introduction; Experimental mapping and computational prediction of epitopes; Examples of structural vaccinology for bacterial and viral "]
[{"$nulls":4},"pathogens; Concluding remarks and future directions; 6: Cellular Screens to Interrogate the Human T- and B-cell Repertoires and Design Better Vaccines ; Introduction"]
[{"$nulls":4},"Generation of naive B- and T-cell repertoires7: Novel Strategies of Vaccine Administration: The Science Behind Epidermal and Dermal Immunization; Introduction; The skin layers; Skin antigen-presenting cells and other players in vaccination; Principles and methods in skin immunization; Vaccine formulation and immunity; Immunological advantage of epidermal and dermal immunization; 8: Toll-like Receptors as Targets to Develop Novel Adjuvants; Introduction; Innate immunity; TLR-based adjuvants in high-priority vaccines; Lessons learned from studies of TLR agonists as adjuvants"]
[{"$nulls":4},"Safety considerations of TLR agonistsChallenges for the next decade; 9: The Importance of Cell-mediated Immunity for Bacterial Vaccines ; Introduction; T-cell responses to bacterial infection; Targeting cellular immunity for novel anti-bacterial vaccine design; 10: T-cell-inducing Vaccines; Introduction; How can we measure T-cell responses?; Technologies for inducing T-cell responses by vaccination; Heterologous prime-boost immunization; Successful clinical development of T-cell vaccines; 11: Exploiting the Mutanome for Personalized Cancer Immunotherapy"]
[{"$nulls":4},"Cancer mutations as therapeutic targets"]
[null,null,null,"Sommario/riassunto","Since the publication of our first book book \"\"Vaccine Design: Innovative Approaches and Novel Strategies\"\" in 2011, the field of vaccinology has advanced significantly. The application of new sophisticated 'omics' technologies and the use of pioneering approaches have yielded a wealth of new data. This new book aims to distill the most important new findings to provide a timely overview of the field. Written by leading experts in the field, each chapter affords a critical insight to a particular topic, reviews current research, discusses future direction and aims to stimulate discussion. The"]
[null,"2.","Record Nr.",null,"UNINA9910146829703321"]
[null,null,"Titolo",null,"2005 IEEE International Test Conference (ITC) : 8-10 November, 2005, Austin, TX"]
[null,null,"Pubbl/distr/stampa",null,"[Place of publication not identified], : Institute of Electrical and Electronics Engineers, 2005"]
[null,null,"ISBN",null,"9781509097678"]
[{"$nulls":4},"1509097678"]
[null,null,"Disciplina",null,"621.3815/48"]
[null,null,"Soggetti",null,"Integrated circuits - Testing"]
[{"$nulls":4},"Semiconductors - Testing"]
[{"$nulls":4},"Electronics"]
[{"$nulls":4},"Electrical Engineering"]
[{"$nulls":4},"Electrical & Computer Engineering"]
[{"$nulls":4},"Engineering & Applied Sciences"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Bibliographic Level Mode of Issuance: Monograph"]
[null,"3.","Record Nr.",null,"UNINA9910161648203321"]
[null,null,"Autore",null,"Zaritsky Arieh"]
[null,null,"Titolo",null,"The Bacterial Cell: Coupling between Growth, Nucleoid Replication, Cell Division and Shape"]
[null,null,"Pubbl/distr/stampa",null,"Frontiers Media SA, 2016"]
[null,null,"Descrizione fisica",null,"1 online resource (324 p.)"]
[null,null,"Collana",null,"Frontiers Research Topics"]
[null,null,"Soggetti",null,"Microbiology (non-medical)"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Sommario/riassunto","Bacterial Physiology was inaugurated as a discipline by the seminal research of Maaløe, Schaechter and Kjeldgaard published in 1958. Their work clarified the relationship between cell composition and growth rate and led to unravel the temporal coupling between chromosome replication and the subsequent cell division by Helmstetter et al. a decade later. Now, after half a century this field has become a major research direction that attracts interest of many scientists from different disciplines. The outstanding question how the most basic cellular processes - mass growth, chromosome replication and cell division - are inter-coordinated in both space and time is still unresolved at the molecular level. Several particularly pertinent questions that are intensively studied follow: (a) what is the primary signal to place the Z-ring precisely between the two replicating and segregating nucleoids? (b) Is this coupling related to the structure and position of the nucleoid itself? (c) How does a bacterium determine and maintain its shape and dimensions? Possible answers include gene expression-based mechanisms, self-organization of protein assemblies and physical principles such as micro-phase separations by excluded volume interactions, diffusion ratchets and membrane stress or curvature. The relationships between biochemical reactions and physical forces are yet to be conceived and discovered. This e-book discusses the above mentioned and related questions. The book also serves as an important depository for state-of-the-art technologies, methods, theoretical simulations and innovative ideas and hypotheses for future testing. Integrating the information gained from various "]
[{"$nulls":4},"angles will likely help decipher how a relatively simple cell such as a bacterium incorporates its multitude of pathways and processes into a highly efficient self-organized system. The knowledge may be helpful in the ambition to artificially reconstruct a simple living system and to develop new antibacterial drugs."]