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[null,"1.","Record Nr.",null,"UNINA9910818732603321"]
[null,null,"Autore",null,"Pocock Stuart J."]
[null,null,"Titolo",null,"Clinical trials : a practical approach / / Stuart J. Pocock"]
[null,null,"Pubbl/distr/stampa",null,"Chichester, England : , : John Wiley & Sons, , 1983"]
[{"$nulls":4},"©1983"]
[null,null,"ISBN",null,"1-118-79391-9"]
[{"$nulls":4},"1-118-79392-7"]
[null,null,"Descrizione fisica",null,"1 online resource (280 p.)"]
[null,null,"Collana",null,"A Wiley medical publication Clinical trials"]
[null,null,"Disciplina",null,"615/.7/0724"]
[null,null,"Soggetti",null,"Clinical trials"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references and index."]
[null,null,"Nota di contenuto",null,"Cover; Title Page; Contents; Preface; 1. Introduction: The Rationale of Clinical Trials; 1.1 Types of clinical trial; 1.2 Controlled clinical trials and the scientific method; 1.3 An example of a clinical trial for primary breast cancer; 2. The Historical Development of Clinical Trials; 2.1 Clinical trials before 1950; 2.2 Clinical trials since 1950; 2.3 Cancer chemotherapy in the United States; 2.4 Treatment of acute myocardial infarction; 2.5 The pharmaceutical industry; 3. Organization and Planning; 3.1 The protocol; 3.2 Administration, staff and finance; 3.3 Selection of patients"]
[{"$nulls":4},"3.4 Treatment schedules 3.5 Evaluation of patient response; 4. The Justification for Randomized Controlled Trials; 4.1 Problems with uncontrolled trials; 4.2 Problems with historical controls; 4.3 Problems with concurrent non-randomized controls; 4.4 Is randomization feasible?; 5. Methods of Randomization; 5.1 Patient registration; 5.2 Preparing the randomization list; 5.3 Stratified randomization; 5.4 Unequal randomization; 6. Blinding and Placebos; 6.1 The justification for double-blind trials; 6.2 The conduct of double-blind trials; 6.3 When is blinding feasible?; 7. Ethical Issues"]
[{"$nulls":4},"7.1 Medical progress and individual patient care 7.2 Informed patient consent; 8. Crossover Trials; 8.1 Within-patient comparisons; 8.2 The two-period crossover design; 8.3 The analysis and interpretation of crossover trials; 8.4 Multi-period crossover designs; 9. The Size of a Clinical Trial; 9.1 Statistical methods for determining trial size; 9.2 The realistic assessment of trial size; 9.3 The inadequacy of small trials; 9.4 Multi-centre trials; 9.5 The number of treatments and factorial designs; "]
[{"$nulls":4},"10. Monitoring Trial Progress; 10.1 Reasons for monitoring; 10.2 Interim analyses"]
[{"$nulls":4},"10.3 Repeated significance testing: group sequential designs 10.4 Continuous sequential designs; 11. Forms and Data Management; 11.1 Form design; 11.2 Data management; 11.3 The use of computers; 12. Protocol Deviations; 12.1 Ineligible patients; 12.2 Non-compliance and incomplete evaluation; 12.3 Inclusion of withdrawals in analysis; 13. Basic Principles of Statistical Analysis; 13.1 Describing the data; 13.2 Significance tests; 13.3 Estimation and confidence limits; 14. Further Aspects of Data Analysis; 14.1 Prognostic factors; 14.2 The analysis of survival data; 14.3 Multiplicity of data"]
[{"$nulls":4},"15. Publication and Interpretation of Findings 15.1 Trial reports and their critical evaluation; 15.2 An excess of false-positives; 15.3 Combining evidence and overall strategy; References; Index"]
[null,null,null,"Sommario/riassunto","This comprehensive, unified text on the principles and practice of clinical trials presents a detailed account of how to conduct the trials. It describes the design, analysis, and interpretation of clinical trials in a non-technical manner and provides a general perspective on their historical development, current status, and future strategy. Features examples derived from the author's personal experience."]