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[null,"1.","Record Nr.",null,"UNINA9910818426803321"]
[null,null,"Autore",null,"Levy Gilberto"]
[null,null,"Titolo",null,"The biostatistics of aging : from Gompertzian mortality and to an index of aging-relatedness / / Gilberto Levy, Bruce Levin"]
[null,null,"Pubbl/distr/stampa",null,"Hoboken, NJ : , : John Wiley & Sons Inc., , [2014]"]
[{"$nulls":4},"©2014"]
[null,null,"ISBN",null,"1-118-64584-7"]
[{"$nulls":4},"1-118-64567-7"]
[null,null,"Descrizione fisica",null,"1 online resource (270 p.)"]
[null,null,"Disciplina",null,"571.8/78"]
[null,null,"Soggetti",null,"Aging - Statistical methods"]
[{"$nulls":4},"Mortality - Statistical methods"]
[{"$nulls":4},"Life spans (Biology)"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references and index."]
[null,null,"Nota di contenuto",null,"THE BIOSTATISTICS OF AGING: From Gompertzian Mortality to an Index of Aging-Relatedness; Copyright; CONTENTS; PREFACE AND ACKNOWLEDGMENT; 1 Introduction; 2 An Account of Gompertzian Mortality through Statistical and Evolutionary Arguments; 2.1 The Statistical Theory of Extreme Values; 2.1.1 Background to Results; 2.1.2 Original Results; 2.2 The Evolutionary Theory of Aging; 2.2.1 The Argument for Gompertzian Mortality; 2.2.2 Boundaries of the Argument; 3 The Argument against Gompertzian Mortality; 3.1 Departures from the Gompertz Model; 3.2 An Evolution-Based Model of Causation"]
[{"$nulls":4},"4 The Index of Aging-Relatedness 4.1 A Survival Mixture Model of the Gompertz and Weibull Distributions; 4.2 Definition and Interpretation of the Index of Aging-Relatedness; 4.3 The Survival Mixture Model and Competing Risks; 4.4 Estimation of the Model Parameters; 4.5 Illustrative Application: The Israeli Ischemic Heart Disease Study; 4.6 Precision of Estimation; 5 Discussion: Implications; 5.1 The Meaning of the Gompertz Parameter; 5.2 Age as a Risk Factor for Disease; 5.3 Are Aging-Related Diseases an Integral Part of Aging?; 5.4 Biological versus Chronological Aging"]
[{"$nulls":4},"5.5 The Public Health Notion of Compression of Morbidity 5.6 A Picture of Aging for the Twenty-First Century; APPENDIX A: PROOFS OF RESULTS IN SECTION 2.1.2 WITH SOME EXTENSIONS; APPENDIX B: "]
[{"$nulls":4},"DERIVATION OF HAMILTON'S EQUATION FOR THE FORCE OF NATURAL SELECTION ON MORTALITY; APPENDIX C: SOME PROPERTIES OF THE GOMPERTZ AND WEIBULL DISTRIBUTIONS; APPENDIX D: FIRST AND SECOND PARTIAL DERIVATIVES OF THE MIXTURE LOG-LIKELIHOOD FUNCTION; APPENDIX E: EXPECTATION-CONDITIONAL MAXIMIZATION(ECM) ALGORITHM; APPENDIX F: R PROGRAM; REFERENCES; AUTHOR INDEX; SUBJECT INDEX"]
[null,null,null,"Sommario/riassunto","A practical and clarifying approach to aging and aging-related diseases  Providing a thorough and extensive theoretical framework, The Biostatistics of Aging: From Gompertzian Mortality to an Index of Aging-Relatedness addresses the surprisingly subtle notion-with consequential biomedical and public health relevance-of what it means for a condition to be related to aging. In this pursuit, the book presents a new quantitative method to examine the relative contributions of genetic and environmental factors to mortality and disease incidence in a population.  With input fr"]