{"text_format":"2","workbook":"xls","n_sheets":1,"sheets":["report2"],"not_rendered":{"charts":0,"images":0,"macros":0,"external_links":1,"defined_names":1,"comments":0,"pivot_tables":0},"unopened":[],"bounds":{"document_bytes":16777216,"sheet_cells":100000,"run_cost":"one","rows_first":2000,"rows_last":500,"rows_between":2000,"halvings":0,"cell_chars":16384,"cell_head_chars":4096},"cells_cut":0,"cells_raw":0,"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"report2","index":0,"n_rows":28,"n_cols":5,"rows_kept":28,"cut":false,"hidden":false,"merged":[[0,2,0,3],[0,4,0,5],[1,2,1,3],[1,4,1,5],[2,2,2,3],[2,4,2,5],[3,2,3,3],[4,2,4,3],[8,2,8,3],[9,2,9,3],[10,2,10,3],[11,2,11,3],[13,2,13,3],[14,2,14,3],[18,2,18,3]],"flags":["formulas_cached_only"]}
[null,"1.","Record Nr.",null,"UNINA9910815905603321"]
[null,null,"Autore",null,"Richardson M. D"]
[null,null,"Titolo",null,"Fungal infection : diagnosis and management / / Malcolm D. Richardson, David W. Warnock"]
[null,null,"Pubbl/distr/stampa",null,"Chichester, West Sussex, U.K., : Wiley-Blackwell, 2012"]
[null,null,"ISBN",null,"1-283-40610-1"]
[{"$nulls":4},"9786613406101"]
[{"$nulls":4},"1-118-32149-9"]
[{"$nulls":4},"1-4443-6099-X"]
[null,null,"Edizione",null,"[4th ed.]"]
[null,null,"Descrizione fisica",null,"1 online resource (477 p.)"]
[null,null,"Disciplina",null,"616.9/69"]
[null,null,"Soggetti",null,"Mycoses - Diagnosis"]
[{"$nulls":4},"Mycoses - Treatment"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Bibliographic Level Mode of Issuance: Monograph"]
[null,null,null,"Nota di bibliografia","Includes bibliographical references and index."]
[null,null,"Nota di contenuto",null,"Intro -- Fungal Infection : DIAGNOSIS AND MANAGEMENT -- Contents -- Preface to the fourth edition -- Preface to the first edition -- Acknowledgements -- 1 Introduction -- 1.1 The nature of fungi -- 1.2 Classification and nomenclature of fungi and fungal diseases -- 1.3 Fungi as human pathogens -- 1.3.1 The superficial mycoses -- 1.3.2 The subcutaneous mycoses -- 1.3.3 The systemic mycoses -- 1.4 The changing pattern of fungal infection -- 1.5 New directions in diagnosis -- 1.6 New directions in treatment and prevention -- Further reading -- 2 Laboratory diagnosis of fungal infection -- 2.1 Introduction -- 2.2 Collection of specimens -- 2.2.1 Skin, nails and hair -- 2.2.2 Mucous membranes -- 2.2.3 Ear -- 2.2.4 Eye -- 2.2.5 Blood -- 2.2.6 Cerebrospinal fluid -- 2.2.7 Urine -- 2.2.8 Other fluids -- 2.2.9 Lower respiratory tract specimens -- 2.2.10 Pus -- 2.2.11 Bone marrow -- 2.2.12 Tissue -- 2.2.13 Medical devices -- 2.3 Specimens for serological tests -- 2.4 Specimens for antifungal drug level determinations -- 2.5 Transport of specimens -- 2.6 Interpretation of laboratory test results -- 2.6.1 Direct microscopic examination -- 2.6.2 Histopathological examination -- 2.6.3 Immunohistochemistry -- 2.6.4 In situ hybridization -- 2.6.5 Culture -- 2.6.6 Fungal identification -- 2.6.7 Molecular identification -- 2.6.8 Serological tests -- 2.6.9 β-D-glucan detection -- 2.7 Molecular diagnosis of fungal infection -- Further reading -- 3 Antifungal drugs -- 3.1 Introduction "]
[{"$nulls":4},"-- 3.2 Allylamines -- 3.2.1 Mechanism of action -- 3.3 Terbinafine -- 3.3.1 Spectrum of activity -- 3.3.2 Acquired resistance -- 3.3.3 Pharmacokinetics -- 3.3.4 Pharmaceutics -- 3.3.5 Therapeutic use -- 3.3.6 Mode of administration -- 3.3.7 Drug interactions -- 3.3.8 Toxicity and adverse reactions -- 3.4 Other allylamine compounds for topical administration -- 3.4.1 Naftifine."]
[{"$nulls":4},"3.5 Azoles -- 3.5.1 Mechanism of action -- 3.5.2 Acquired resistance -- 3.5.3 Drug interactions -- 3.6 Fluconazole -- 3.6.1 Spectrum of activity -- 3.6.2 Acquired resistance -- 3.6.3 Pharmacokinetics -- 3.6.4 Pharmaceutics -- 3.6.5 Therapeutic use -- 3.6.6 Mode of administration -- 3.6.7 Drug interactions -- 3.6.8 Toxicity and adverse reactions -- 3.7 Itraconazole -- 3.7.1 Spectrum of activity -- 3.7.2 Acquired resistance -- 3.7.3 Pharmacokinetics -- 3.7.4 Pharmaceutics -- 3.7.5 Therapeutic use -- 3.7.6 Mode of administration -- 3.7.7 Drug interactions -- 3.7.8 Toxicity and adverse reactions -- 3.8 Ketoconazole -- 3.8.1 Spectrum of activity -- 3.8.2 Acquired resistance -- 3.8.3 Pharmacokinetics -- 3.8.4 Pharmaceutics -- 3.8.5 Therapeutic use -- 3.8.6 Mode of administration -- 3.8.7 Drug interactions -- 3.8.8 Toxicity and adverse reactions -- 3.9 Posaconazole -- 3.9.1 Spectrum of activity -- 3.9.2 Acquired resistance -- 3.9.3 Pharmacokinetics -- 3.9.4 Pharmaceutics -- 3.9.5 Therapeutic use -- 3.9.6 Mode of administration -- 3.9.7 Drug interactions -- 3.9.8 Toxicity and adverse reactions -- 3.10 Voriconazole -- 3.10.1 Spectrum of activity -- 3.10.2 Acquired resistance -- 3.10.3 Pharmacokinetics -- 3.10.4 Pharmaceutics -- 3.10.5 Therapeutic use -- 3.10.6 Mode of administration -- 3.10.7 Drug interactions -- 3.10.8 Toxicity and adverse reactions -- 3.11 Other imidazole compounds for topical administration -- 3.11.1 Bifonazole -- 3.11.2 Butoconazole -- 3.11.3 Clotrimazole -- 3.11.4 Econazole nitrate -- 3.11.5 Fenticonazole nitrate -- 3.11.6 Isoconazole nitrate -- 3.11.7 Miconazole nitrate -- 3.11.8 Oxiconazole -- 3.11.9 Sertaconazole nitrate -- 3.11.10 Sulconazole nitrate -- 3.11.11 Terconazole -- 3.11.12 Tioconazole -- 3.12 Echinocandins -- 3.12.1 Mechanism of action -- 3.12.2 Spectrum of activity -- 3.12.3 Acquired resistance -- 3.12.4 Drug interactions."]
[{"$nulls":4},"3.13 Anidulafungin -- 3.13.1 Pharmacokinetics -- 3.13.2 Pharmaceutics -- 3.13.3 Therapeutic use -- 3.13.4 Mode of administration -- 3.13.5 Drug interactions -- 3.13.6 Toxicity and adverse reactions -- 3.14 Caspofungin -- 3.14.1 Pharmacokinetics -- 3.14.2 Pharmaceutics -- 3.14.3 Therapeutic use -- 3.14.4 Mode of administration -- 3.14.5 Drug interactions -- 3.14.6 Toxicity and adverse reactions -- 3.15 Micafungin -- 3.15.1 Pharmacokinetics -- 3.15.2 Pharmaceutics -- 3.15.3 Therapeutic use -- 3.15.4 Mode of administration -- 3.15.5 Drug interactions -- 3.15.6 Toxicity and adverse reactions -- 3.16 Polyenes -- 3.16.1 Mechanism of action -- 3.17 Amphotericin B -- 3.17.1 Spectrum of activity -- 3.17.2 Acquired resistance -- 3.17.3 Pharmacokinetics -- 3.17.4 Pharmaceutics -- 3.17.5 Therapeutic use -- 3.17.6 Mode of administration -- 3.17.7 Drug interactions -- 3.17.8 Toxicity and adverse reactions -- 3.18 Other polyene compounds for topical administration -- 3.18.1 Natamycin -- 3.18.2 Nystatin -- 3.19 Flucytosine -- 3.19.1 Mechanism of action -- 3.19.2 Spectrum of activity -- 3.19.3 Acquired resistance -- 3.19.4 Pharmacokinetics -- 3.19.5 Pharmaceutics -- 3.19.6 Therapeutic use -- 3.19.7 Mode of administration -- 3.19.8 Drug interactions -- 3.19.9 Toxicity and adverse reactions -- 3.20 Griseofulvin -- 3.20.1 Mechanism of action -- 3.20.2 Spectrum of activity -- 3.20.3 Acquired resistance -- 3.20.4 Pharmacokinetics -- 3.20.5 Pharmaceutics -- 3.20.6 Therapeutic use -- 3.20.7 Mode of "]
[{"$nulls":4},"administration -- 3.20.8 Drug interactions -- 3.20.9 Toxicity and adverse reactions -- 3.21 Other miscellaneous compounds for topical administration -- 3.21.1 Amorolfine hydrochloride -- 3.21.2 Butenafine hydrochloride -- 3.21.3 Ciclopiroxolamine -- 3.21.4 Haloprogin -- 3.21.5 Tolnaftate -- 3.22 Prophylactic treatment for prevention of fungal infection."]
[{"$nulls":4},"3.23 Empirical treatment of suspected fungal infection in the neutropenic patient -- 3.24 Pre-emptive antifungal treatment -- 3.25 Combination antifungal treatment of invasive fungal infections -- 3.26 Laboratory monitoring -- 3.26.1 Antifungal drug susceptibility testing -- 3.26.2 Monitoring of blood concentrations of antifungal drugs -- Further reading -- 4 Dermatophytosis -- 4.1 Introduction -- 4.2 The causal organisms and their habitat -- 4.3 Epidemiology -- 4.4 Laboratory diagnosis of dermatophytosis -- 4.5 Tinea capitis -- 4.5.1 Definition -- 4.5.2 Geographical distribution -- 4.5.3 Causal organisms -- 4.5.4 Epidemiology -- 4.5.5 Clinical manifestations -- 4.5.6 Differential diagnosis -- 4.5.7 Essential investigations and their interpretation -- 4.5.8 Management -- 4.5.9 Prevention -- 4.6 Tinea corporis -- 4.6.1 Definition -- 4.6.2 Geographical distribution -- 4.6.3 Causal organisms -- 4.6.4 Epidemiology -- 4.6.5 Clinical manifestations -- 4.6.6 Differential diagnosis -- 4.6.7 Essential investigations and their interpretation -- 4.6.8 Management -- 4.6.9 Prevention -- 4.7 Tinea cruris -- 4.7.1 Definition -- 4.7.2 Geographical distribution -- 4.7.3 Causal organisms -- 4.7.4 Epidemiology -- 4.7.5 Clinical manifestations -- 4.7.6 Differential diagnosis -- 4.7.7 Essential investigations and their interpretation -- 4.7.8 Management -- 4.7.9 Prevention -- 4.8 Tinea pedis -- 4.8.1 Definition -- 4.8.2 Geographical distribution -- 4.8.3 Causal organisms -- 4.8.4 Epidemiology -- 4.8.5 Clinical manifestations -- 4.8.6 Differential diagnosis -- 4.8.7 Essential investigations and their interpretation -- 4.8.8 Management -- 4.8.9 Prevention -- 4.9 Tinea manuum -- 4.9.1 Definition -- 4.9.2 Geographical distribution -- 4.9.3 Causal organisms -- 4.9.4 Epidemiology -- 4.9.5 Clinical manifestations -- 4.9.6 Differential diagnosis."]
[{"$nulls":4},"4.9.7 Essential investigations and their interpretation -- 4.9.8 Management -- 4.9.9 Prevention -- 4.10 Tinea unguium -- 4.10.1 Definition -- 4.10.2 Geographical distribution -- 4.10.3 Causal organisms -- 4.10.4 Epidemiology -- 4.10.5 Clinical manifestations -- 4.10.6 Differential diagnosis -- 4.10.7 Essential investigations and their interpretation -- 4.10.8 Management -- 4.10.9 Prevention -- Further reading -- 5 Superficial candidosis -- 5.1 Definition -- 5.2 Geographical distribution -- 5.3 The causal organisms and their habitat -- 5.4 Epidemiology -- 5.5 Clinical manifestations -- 5.5.1 Oropharyngeal candidosis -- 5.5.2 Vaginal candidosis -- 5.5.3 Penile candidosis -- 5.5.4 Cutaneous candidosis -- 5.5.5 Candida nail infection -- 5.5.6 Chronic mucocutaneous candidosis -- 5.6 Essential investigations and their interpretation -- 5.7 Management -- 5.7.1 Oropharyngeal candidosis -- 5.7.2 Vaginal candidosis -- 5.7.3 Penile candidosis -- 5.7.4 Cutaneous candidosis -- 5.7.5 Candida nail infection -- 5.7.6 Chronic mucocutaneous candidosis -- 5.8 Prevention -- Further reading -- 6 Other cutaneous fungal infections -- 6.1 Pityriasis versicolor -- 6.1.1 Definition -- 6.1.2 Geographical distribution -- 6.1.3 The causal organisms and their habitat -- 6.1.4 Epidemiology -- 6.1.5 Clinical manifestations -- 6.1.6 Differential diagnosis -- 6.1.7 Essential investigations and their interpretation -- 6.1.8 Management -- 6.2 Other Malassezia infections -- 6.2.1 Malassezia folliculitis -- 6.2.2 Seborrhoeic dermatitis -- 6.3 Piedra -- 6.4 White piedra -- 6.4.1 Definition -- 6.4.2 Geographical distribution "]
[{"$nulls":4},"-- 6.4.3 The causal organisms and their habitat -- 6.4.4 Epidemiology -- 6.4.5 Clinical manifestations -- 6.4.6 Differential diagnosis -- 6.4.7 Essential investigations and their interpretation -- 6.4.8 Management -- 6.5 Black piedra -- 6.5.1 Definition."]
[{"$nulls":4},"6.5.2 Geographical distribution."]
[null,null,null,"Sommario/riassunto","\"Fungal Infection: Diagnosis and Management,\" 4th Edition is a concise and up-to-date guide to the clinical manifestations, laboratory diagnosis and management of superficial, subcutaneous and systemic fungal infections.This highly acclaimed book has been extensively revised and updated throughout to ensure all drug and dosage recommendations are accurate and in agreement with current guidelines. A new chapter on infections caused by \"Pneumocystis jirovecii\" has been added. The book has been designed to enable rapid information retrieval and to help clinicians make informed decisions about diagnosis and patient management. Each chapter concludes with a list of recent key publications which have been carefully selected to facilitate efficient access to further information on specific aspects of fungal infections.Clinical microbiologists, infectious disease specialists, as well as dermatologists, hematologists and oncologists, can depend on this contemporary text for authoritative information and the background necessary to understand fungal infections."]