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[null,"1.","Record Nr.",null,"UNINA9910813940903321"]
[null,null,"Autore",null,"Wallace Rodrick"]
[null,null,"Titolo",null,"A mathematical approach to multilevel, multiscale health interventions : pharmaceutical industry decline and policy response / / Rodrick Wallace, Deborah Wallace, Columbia University, USA"]
[null,null,"Pubbl/distr/stampa",null,"London, : Imperial College Press, 2013"]
[{"$nulls":4},"London : , : Imperial College Press, , [2013]"]
[{"$nulls":4},"�2013"]
[null,null,"ISBN",null,"1-299-46216-2"]
[{"$nulls":4},"1-84816-997-3"]
[null,null,"Descrizione fisica",null,"1 online resource (xi, 225 pages)"]
[null,null,"Collana",null,"Gale eBooks"]
[null,null,"Disciplina",null,"615.5/80151"]
[null,null,"Soggetti",null,"Drug development"]
[{"$nulls":4},"Drugs - Research"]
[{"$nulls":4},"Drugs - Design - Mathematical models"]
[{"$nulls":4},"Medical geography"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references and index."]
[null,null,"Nota di contenuto",null,"Preface; Contents; 1. BEYOND MAGIC BULLETS; 1.1 The Pharmaceutical Catastrophe; 1.2 A New Perspective; 1.3 Cognition as `Language'; 1.4 The Human Cognome; 2. EXPANDING THE THEORY; 2.1 No Free Lunch; 2.2 Multiple Broadcasts, Punctuated Detection; 2.3 Metabolic Constraints; 2.4 Environmental Signals; 3. DYNAMIC `REGRESSION' MODELS; 3.1 The Simplest Approach; 3.2 A Rate Distortion Reformulation; 3.3 Multiple Time Scales; 3.4 Incoming Information; 3.5 Pathologies; 3.6 Refining the Model; 4. AN EVOLUTIONARY EXCURSION; 4.1 Introduction; 4.2 Ecosystems as Information Sources; 4.3 Genetic Heritage"]
[{"$nulls":4},"4.4 Gene Expression4.5 Interacting Information Sources; 4.6 Conclusions; 5. EXAMPLE: MENTAL DISORDERS; 5.1 Introduction; 5.2 Two Classes; 5.3 Global Broadcast Models; 5.4 Gene Expression; 5.5 Summary; 6. EXAMPLE: PROTEIN FOLDING; 6.1 Introduction; 6.2 Spontaneous Symmetry Breaking; 6.3 A Formal Approach; 6.4 The Energy Picture; 6.5 The Developmental Picture; 6.6 A Comprehensive Treatment; 6.7 Aging and Protein Folding; 6.8 Summary; 7. EXAMPLE: GLYCOME DETERMINANTS; 7.1 Introduction; 7.2 Stochastic Topology; 7.3 The Glycomic Conundrum; 7.4 Another Cognitive Paradigm"]
[{"$nulls":4},"7.5 Regulating Glycan Determinants7.6 Glycan Spectra; 7.7 Summary; 8. EXAMPLE: GLYCAN/LECTIN LOGIC GATES; 8.1 Introduction; 8.2 The Critical Exponent; 8.3 Two Examples; 8.4 Information Catalysis; 8.5 A Tiling Symmetry Model; 8.6 Summary; 9. EXAMPLE: IDP LOGIC GATES; 9.1 Introduction; 9.2 Symbolic Dynamics of Molecular Switching; 9.3 Another Dual Information Source; 9.4 Information Catalysis; 9.5 Summary; 10. TREATMENT; 10.1 The Generalized Retina; 10.2 Therapeutic Efficacy; 10.3 Psychosocial Stress; 10.4 Flight, Fight, and Helplessness; 10.5 Institutions as Niche Construction"]
[{"$nulls":4},"10.6 The Hall of Mirrors10.7 Side Effects Reconsidered; 11. HISTORY AND HEALTH; 11.1 Malaria and the Fulani; 11.2 The American Catastrophe; 12. BEYOND GLASPERLENSPIEL; 13. MATHEMATICAL APPENDIX; 13.1 The Tuning Theorem; 13.2 The Rate Distortion Theorem; 13.3 Stochastic Differential Equations; 13.4 Morse Theory; 13.5 Groupoids; 13.6 `Biological' Renormalization; 13.7 Large Deviations; Bibliography; Index"]
[null,null,null,"Sommario/riassunto","This book, based on published studies, takes a unique perspective on the 30-year collapse of pharmaceutical industry productivity in the search for small molecule \"magic bullet\" interventions. The relentless escalation of inflation-adjusted cost per approved medicine in the United States - from 200 million in 1950 to 1.2 billion in 2010 - has driven industry giants to, at best, slavish imitation in drug design, and at worst, abandonment of research and embracing of widespread fraud in consumer marketing.The book adapts formalism across a number of disciplines to the strategy for design of mu"]
[null,"2.","Record Nr.",null,"UNINA9910741142003321"]
[null,null,"Titolo",null,"Advances in applied self-organizing systems / / Mikhail Prokopenko, editor"]
[null,null,"Pubbl/distr/stampa",null,"London ; ; New York, : Springer, c2013"]
[null,null,"ISBN",null,"1-4471-5113-5"]
[null,null,"Edizione",null,"[2nd ed.]"]
[null,null,"Descrizione fisica",null,"1 online resource (425 p.)"]
[null,null,"Collana",null,"Advanced information and knowledge processing"]
[null,null,"Disciplina",null,"003.7"]
[null,null,"Soggetti",null,"Self-organizing systems"]
[{"$nulls":4},"Self-organizing systems - Data processing"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references and index."]
[null,null,"Nota di contenuto",null,"Preface -- Part I – Introduction -- Design versus Self-Organization -- Foundations and Formalizations of Self-Organization -- Part II – Distributed Management and Control -- Self-Organizing Traffic Lights: A Realistic Simulation -- Self-Organizing Sensing of Structures: Monitoring a Space Vehicle Thermal Protection System -- Decentralized Decision Making for Ad-hoc Multi-Agent Systems -- Learning Mutation Strategies for Evaluation and Adaptation of a Simulated Snakebot -- Self-Organization as Phase Transition in Decentralized Groups of Robots: A Study Based on Boltzmann Entropy -- Distributed Control of Microscopic Robots in Biomedical Applications -- Part III – Self-Organizing Computation -- Self-Organizing Computing Systems: Songline Processors -- Self-Organizing Nomadic Services in Grids -- Immune System Support for Scheduling -- Formal Immune Networks: Self-Organization and Real-World Applications -- A Model for Self-Organizing Data Visualization using Decentralized Multi-Agent Systems -- Memristive Excitable Automata: Structural Dynamics, Phenomenology, Localizations and Conductive Pathways -- Part IV – Discussion -- A Turing Test for Emergence -- Index."]
[null,null,null,"Sommario/riassunto","How do we design a self-organizing system? Is it possible to validate and control non-deterministic dynamics? What is the right balance between the emergent patterns that bring robustness, adaptability and scalability, and the traditional need for verification and validation of the outcomes? The last several decades have seen much progress from original ideas of “emergent functionality” and “design for emergence”, to sophisticated mathematical formalisms of “guided self-"]
[{"$nulls":4},"organization”. And yet the main challenge remains, attracting the best scientific and engineering expertise to this elusive problem. This book presents state-of-the-practice of successfully engineered self-organizing systems, and examines ways to balance design and self-organization in the context of applications. As demonstrated in this second edition of Advances in Applied Self-Organizing Systems, finding this balance helps to deal with practical challenges as diverse as navigation of microscopic robots within blood vessels, self-monitoring aerospace vehicles, collective and modular robotics adapted for autonomous reconnaissance and surveillance, self-managing grids and multiprocessor scheduling, data visualization and self-modifying digital and analog circuitry, intrusion detection in computer networks, reconstruction of hydro-physical fields, traffic management, immunocomputing and nature-inspired computation. Many algorithms proposed and discussed in this volume are biologically inspired, and the reader will also gain an insight into cellular automata, genetic algorithms, artificial immune systems, snake-like locomotion, ant foraging, birds flocking, neuromorphic circuits, amongst others. Demonstrating the practical relevance and applicability of self-organization, Advances in Applied Self-Organizing Systems will be an invaluable tool for advanced students and researchers in a wide range of fields."]