{"text_format":"2","workbook":"xls","n_sheets":1,"sheets":["report2"],"not_rendered":{"charts":0,"images":0,"macros":0,"external_links":1,"defined_names":1,"comments":0,"pivot_tables":0},"unopened":[],"bounds":{"document_bytes":16777216,"sheet_cells":100000,"run_cost":"one","rows_first":2000,"rows_last":500,"rows_between":2000,"halvings":0,"cell_chars":16384,"cell_head_chars":4096},"cells_cut":0,"cells_raw":0,"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"report2","index":0,"n_rows":25,"n_cols":5,"rows_kept":25,"cut":false,"hidden":false,"merged":[[0,2,0,3],[0,4,0,5],[1,2,1,3],[1,4,1,5],[2,2,2,3],[2,4,2,5],[3,2,3,3],[6,2,6,3],[8,2,8,3],[9,2,9,3],[10,2,10,3],[11,2,11,3],[15,2,15,3],[16,2,16,3],[20,2,20,3]],"flags":["formulas_cached_only"]}
[null,"1.","Record Nr.",null,"UNINA9910813940903321"]
[null,null,"Autore",null,"Wallace Rodrick"]
[null,null,"Titolo",null,"A mathematical approach to multilevel, multiscale health interventions : pharmaceutical industry decline and policy response / / Rodrick Wallace, Deborah Wallace, Columbia University, USA"]
[null,null,"Pubbl/distr/stampa",null,"London, : Imperial College Press, 2013"]
[{"$nulls":4},"London : , : Imperial College Press, , [2013]"]
[{"$nulls":4},"�2013"]
[null,null,"ISBN",null,"1-299-46216-2"]
[{"$nulls":4},"1-84816-997-3"]
[null,null,"Descrizione fisica",null,"1 online resource (xi, 225 pages)"]
[null,null,"Collana",null,"Gale eBooks"]
[null,null,"Disciplina",null,"615.5/80151"]
[null,null,"Soggetti",null,"Drug development"]
[{"$nulls":4},"Drugs - Research"]
[{"$nulls":4},"Drugs - Design - Mathematical models"]
[{"$nulls":4},"Medical geography"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references and index."]
[null,null,"Nota di contenuto",null,"Preface; Contents; 1. BEYOND MAGIC BULLETS; 1.1 The Pharmaceutical Catastrophe; 1.2 A New Perspective; 1.3 Cognition as `Language'; 1.4 The Human Cognome; 2. EXPANDING THE THEORY; 2.1 No Free Lunch; 2.2 Multiple Broadcasts, Punctuated Detection; 2.3 Metabolic Constraints; 2.4 Environmental Signals; 3. DYNAMIC `REGRESSION' MODELS; 3.1 The Simplest Approach; 3.2 A Rate Distortion Reformulation; 3.3 Multiple Time Scales; 3.4 Incoming Information; 3.5 Pathologies; 3.6 Refining the Model; 4. AN EVOLUTIONARY EXCURSION; 4.1 Introduction; 4.2 Ecosystems as Information Sources; 4.3 Genetic Heritage"]
[{"$nulls":4},"4.4 Gene Expression4.5 Interacting Information Sources; 4.6 Conclusions; 5. EXAMPLE: MENTAL DISORDERS; 5.1 Introduction; 5.2 Two Classes; 5.3 Global Broadcast Models; 5.4 Gene Expression; 5.5 Summary; 6. EXAMPLE: PROTEIN FOLDING; 6.1 Introduction; 6.2 Spontaneous Symmetry Breaking; 6.3 A Formal Approach; 6.4 The Energy Picture; 6.5 The Developmental Picture; 6.6 A Comprehensive Treatment; 6.7 Aging and Protein Folding; 6.8 Summary; 7. EXAMPLE: GLYCOME DETERMINANTS; 7.1 Introduction; 7.2 Stochastic Topology; 7.3 The Glycomic Conundrum; 7.4 Another Cognitive Paradigm"]
[{"$nulls":4},"7.5 Regulating Glycan Determinants7.6 Glycan Spectra; 7.7 Summary; 8. EXAMPLE: GLYCAN/LECTIN LOGIC GATES; 8.1 Introduction; 8.2 The Critical Exponent; 8.3 Two Examples; 8.4 Information Catalysis; 8.5 A Tiling Symmetry Model; 8.6 Summary; 9. EXAMPLE: IDP LOGIC GATES; 9.1 Introduction; 9.2 Symbolic Dynamics of Molecular Switching; 9.3 Another Dual Information Source; 9.4 Information Catalysis; 9.5 Summary; 10. TREATMENT; 10.1 The Generalized Retina; 10.2 Therapeutic Efficacy; 10.3 Psychosocial Stress; 10.4 Flight, Fight, and Helplessness; 10.5 Institutions as Niche Construction"]
[{"$nulls":4},"10.6 The Hall of Mirrors10.7 Side Effects Reconsidered; 11. HISTORY AND HEALTH; 11.1 Malaria and the Fulani; 11.2 The American Catastrophe; 12. BEYOND GLASPERLENSPIEL; 13. MATHEMATICAL APPENDIX; 13.1 The Tuning Theorem; 13.2 The Rate Distortion Theorem; 13.3 Stochastic Differential Equations; 13.4 Morse Theory; 13.5 Groupoids; 13.6 `Biological' Renormalization; 13.7 Large Deviations; Bibliography; Index"]
[null,null,null,"Sommario/riassunto","This book, based on published studies, takes a unique perspective on the 30-year collapse of pharmaceutical industry productivity in the search for small molecule \"magic bullet\" interventions. The relentless escalation of inflation-adjusted cost per approved medicine in the United States - from 200 million in 1950 to 1.2 billion in 2010 - has driven industry giants to, at best, slavish imitation in drug design, and at worst, abandonment of research and embracing of widespread fraud in consumer marketing.The book adapts formalism across a number of disciplines to the strategy for design of mu"]