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[null,"1.","Record Nr.",null,"UNINA9910131807103321"]
[null,null,"Autore",null,"Collotti Enzo"]
[null,null,"Titolo",null,"Impegno civile e passione critica / / a cura di Mariuccia Salvati"]
[null,null,"Pubbl/distr/stampa",null,"Roma, : Viella, 2010"]
[null,null,"Descrizione fisica",null,"P. 1-289"]
[null,null,"Disciplina",null,"940"]
[null,null,"Soggetti",null,"Europe Historiography"]
[null,null,"Lingua di pubblicazione",null,"Italiano"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Sommario/riassunto","Questo libro è il ritratto di un intellettuale, che è anche uno storico dell'Europa del Novecento; oppure dovremmo dire: uno storico che è anche un intellettuale? Difficile separare i due termini nel clima culturale dell'Italia del secondo dopoguerra: quel dimenticato ventennio in cui, \"animato unicamente da passione critica e impegno civile\", l'autore sceglie, movendosi tra Trieste, Roma e Milano, di intraprendere la strada dello studioso di storia, perché solo con uno studio rigoroso del passato sembra possibile rispondere alle domande che l'Europa uscita dalla catastrofe del nazismo pone alla nuova generazione.Letta oggi, la vicenda biografica qui ricostruita - attraverso le memorie del protagonista e poi in dialogo con una storica di una generazione più giovane - sorprende per la ricchezza dei contatti, la varietà dei personaggi che la animano, la presenza di una intellighenzia internazionale impegnata a realizzare e difendere un modello di Europa cosmopolita ispirata a ideali di libertà e giustizia."]
[null,"2.","Record Nr.",null,"UNINA9910810182203321"]
[null,null,"Autore",null,"Rosenberg Michael J"]
[null,null,"Titolo",null,"The agile approach to adaptive research : optimizing efficiency in clinical development / / Michael J. Rosenberg"]
[null,null,"Pubbl/distr/stampa",null,"Hoboken, N.J., : Wiley, c2010"]
[null,null,"ISBN",null,"9786612547645"]
[{"$nulls":4},"9781282547643"]
[{"$nulls":4},"128254764X"]
[{"$nulls":4},"9780470599686"]
[{"$nulls":4},"0470599685"]
[{"$nulls":4},"9780470599679"]
[{"$nulls":4},"0470599677"]
[null,null,"Edizione",null,"[1st ed.]"]
[null,null,"Descrizione fisica",null,"1 online resource (296 p.)"]
[null,null,"Collana",null,"Wiley series on technologies for the pharmaceutical industry"]
[null,null,"Disciplina",null,"615/.19"]
[null,null,"Soggetti",null,"Drug development"]
[{"$nulls":4},"Pharmaceutical industry"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references and index."]
[null,null,"Nota di contenuto",null,"The Agile Approach to Adaptive Research: Optimizing Efficiency in Clinical Development; Contents; Preface; Acknowledgments; 1 Opportunity for Efficiency; The Adaptive Solution; An Industrial Success Story; Signs of Trouble Ahead; Converging Challenges; The Struggle to Replace Lost Revenues; Clinical Research Is the Key; Behind the High Costs of Clinical Development; High Costs and Increasing Prices; Growing Pressures Mandate Greater Efficiency; The High Risk of Current Development Practices; Economic Consequences of Faster Clinical Development; Thriving in a New Era; References"]
[{"$nulls":4},"2 Defining and Extending the Adaptive ApproachThe Adaptive Concept; Knowledge, Time, and Decision Making; The Value of Early Knowledge; The Spectrum of Design and Operational Adaptations; Maximizing the Adaptive Approach: Agile Clinical Development; Measure Performance in Real Time; Metrics in Action; Right Information to the Right Eyes at the Right Time; Make Timely Decisions; Organize Work in Lean Processes; Rework in Clinical Studies; Backflow of Patient Data; Match Technology with Tasks; Objections to Adaptive Methods; Integrity and Validity; The Regulatory Environment"]
[{"$nulls":4},"The Complexity of Clinical ResearchConclusion; References; 3 Design "]
[{"$nulls":4},"Adaptations Part One: Finding the Right Dose; Background; Types of Design Adaptations; Order of Discussion; Dosing Nomenclature; Determining Maximum Safe Dose; Single Arm; Continual Reassessment Method; Other Bayesian Dose-Finding Methods; Determining Optimal Dose (Pruning); Multiple Arms; Improvements over Conventional Approaches to Dose Finding; Dose Selection in Practice; Optimizing Dose Selection; Minimizing Costs Versus Maximizing Information; Surrogate Endpoints; Conclusion; References"]
[{"$nulls":4},"4 Design Adaptations Part Two: Additional Design ChangesSample-Size Reestimation; The Trouble with Planning Estimates; The High Cost of \"Underbuilt\" Studies; The Benefits of Reestimation and Rightsizing; Reestimation and Trial Stages; Rules to Restrict Reestimation; Adjusting Sample Size for Nuisance Parameters; Seamless Designs: Combining Multiple Phases; When to Consider Seamless Studies; Seamless Phase I/Phase II Trials; Seamless Phase II/Phase III Trials; Planning Issues in Seamless Trials; Phase I-II-III Designs; Adaptive Randomization; Response-Adaptive Randomization"]
[{"$nulls":4},"Other Forms of Adaptive RandomizationOther Types of Design Adaptations; Noninferiority-to-Superiority Design; Adaptive Hypotheses and Subpopulations; Treatment Switching; Conclusions; References; 5 Operational Adaptations; Design and Operational Adaptations; The Nature and Significance of Operational Adaptations; Implementing Operational Adaptations; Enrollment and Other Site Issues; Data Quality; Monitoring; Site Closeout and Database Lock; Supporting Functions for Efficient Operations; The Bottom Line; References; 6 Agile Clinical Development; Benefits of Agile Development"]
[{"$nulls":4},"A Development Example"]
[null,null,null,"Sommario/riassunto","Apply adaptive research to improve results in drug development The pharmaceutical industry today faces a deepening crisis: inefficiency in its core business, the development of new drugs. The Agile Approach to Adaptive Research offers a solution. It outlines how adaptive research, using already-available tools and techniques, can enable the industry to streamline clinical trials and reach decision points faster and more efficiently. With a wealth of real-world cases and examples, author Michael Rosenberg gives readers a practical overview of drug development, the problems inh"]