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[null,"1.","Record Nr.",null,"UNINA9910810141703321"]
[null,null,"Autore",null,"Geveci Tunc"]
[null,null,"Titolo",null,"Advanced calculus : using differential functions of several variables / / Tunc Geveci"]
[null,null,"Pubbl/distr/stampa",null,"New York, [New York] (222 East 46th Street, New York, NY 10017) : , : Momentum Press, , 2016"]
[null,null,"ISBN",null,"1-60650-878-4"]
[null,null,"Descrizione fisica",null,"1 online resource (71 pages) : illustrations"]
[null,null,"Disciplina",null,"515"]
[null,null,"Soggetti",null,"Calculus"]
[{"$nulls":4},"Differential calculus"]
[{"$nulls":4},"Libros electronicos."]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Co-published with Cognella Academic Publishing."]
[{"$nulls":4},"Includes index."]
[null,null,"Nota di contenuto",null,"1. Parametrized functions -- Parametrized curves -- Tangent vectors -- Velocity --"]
[{"$nulls":4},"2. Differential equations for acceleration and curvature -- Acceleration -- The moving frame -- Arc length -- Curvature -- Tangential and normal components of acceleration --"]
[{"$nulls":4},"3. Real-valued functions -- Real-valued functions of two variables -- Real-valued functions of three or more variables --"]
[{"$nulls":4},"4. An introduction to partial derivatives -- Limits and continuity -- The definition and evaluation of partial derivatives -- The geometric interpretation of partial derivatives -- Higher-order partial derivatives --"]
[{"$nulls":4},"5. Linear approximations -- Local linear approximations -- The differential -- Functions of more than two variables --"]
[{"$nulls":4},"Index."]
[null,"2.","Record Nr.",null,"UNINA9910367755103321"]
[null,null,"Autore",null,"Contel Maria"]
[null,null,"Titolo",null,"Unconventional Anticancer Metallodrugs and Strategies to Improve their Pharmacological Profile / Maria Contel"]
[null,null,"Pubbl/distr/stampa",null,"MDPI - Multidisciplinary Digital Publishing Institute, 2019"]
[{"$nulls":4},"Basel, Switzerland : , : MDPI, , 2019"]
[null,null,"ISBN",null,"9783039213160"]
[{"$nulls":4},"3039213164"]
[null,null,"Descrizione fisica",null,"1 electronic resource (204 p.)"]
[null,null,"Soggetti",null,"Biology, life sciences"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Sommario/riassunto","For the past 40 years, metal-based drugs have been widely used for the treatment of cancer. Cisplatin and follow-up drugs carboplatin (ParaplatinTM) and oxaliplatin (EloxatinTM) have been the gold standard for metallodrugs in clinical settings as antineoplastic agents. While effective, these drugs (either alone or in combination therapy) have faced a number of clinical challenges resulting from their limited spectrum of activity, high toxicity leading to significant side effects, resistance, poor water solubility, low bioavailability and short circulating time. In the past 10 years, various unconventional non-platinum metal-based agents have emerged as a potential alternative for cancer treatment. These compounds are highly effective and selective in cancers resistant to cisplatin and other chemotherapeutic agents. Research in this area has recently exploded with a relevant number of patents and clinical trials, in addition to reports in scientific journals. Furthermore, in parallel to the synthesis of coordination and organometallic compounds comprising many different metals and unconventional platinum-based derivatives, researchers are focused on optimizing mechanistic and pharmacological features of promising drug candidates. This Special Issue aims to highlight the latest advances in anticancer metallodrugs with a focus on unconventional anticancer agents, as well as novel activation, targeting and delivery strategies aimed at improving their pharmacological profile."]