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[null,"1.","Record Nr.",null,"UNINA9910798538603321"]
[null,null,"Autore",null,"Willis Jon (College teacher)"]
[null,null,"Titolo",null,"All these worlds are yours : the scientific search for alien life / / Jon Willis"]
[null,null,"Pubbl/distr/stampa",null,"New Haven, Connecticut : , : Yale University Press, , [2016]"]
[{"$nulls":4},"©2016"]
[null,null,"ISBN",null,"0-300-22475-3"]
[null,null,"Descrizione fisica",null,"1 online resource (232 p.)"]
[null,null,"Disciplina",null,"576.839"]
[null,null,"Soggetti",null,"Exobiology"]
[{"$nulls":4},"Life on other planets"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Nota di bibliografia","Includes bibliographic references (page [189]-205) and index."]
[null,null,"Nota di contenuto",null,"Front matter -- CONTENTS -- Preface -- Acknowledgments -- One. Alien Extravaganza -- Two. A Universe Fit for Life? -- Three. What on Earth Is Life? -- Four. A Biological Tour of Our Solar System -- Five. Mars: The Riddle in the Sands -- Six. Europa and Enceladus: Life Aquatic? -- Seven. Titan: Nature's Petrochemical Plant -- Eight. Exoplanets: Worlds without End -- Nine. The Search for Extraterrestrial Intelligence -- Ten. The Meaning of (Alien) Life? -- Notes -- References: Billions and Billions of Books -- Index"]
[null,null,null,"Sommario/riassunto","Where would you look for alien life? An astronomer and science popularizer explains the basics of astrobiology to outline five plausible scenarios for finding extraterrestrials Long before space travel was possible, the idea of life beyond Earth transfixed humans. In this fascinating book, astronomer Jon Willis explores the science of astrobiology and the possibility of locating other life in our own galaxy. Describing the most recent discoveries by space exploration missions, including the Kepler space telescope, the Mars Curiosity rover, and the New Horizons probe, Willis asks readers to imagine-and choose among-five scenarios for finding life. He encourages us to wonder whether life might exist within Mars's subsoil ice. He reveals the vital possibilities on the water-ice moons Europa and Enceladus. He views Saturn's moon Titan through the lens of our own planet's ancient past. And, he even looks beyond our solar system, investigating the top candidates for a \"second Earth\" in a myriad of exoplanets and imagining the case of a radio signal arriving from deep space. Covering "]
[{"$nulls":4},"the most up-to-date research, this accessibly written book provides readers with the basic knowledge necessary to decide where they would look for alien life."]
[null,"2.","Record Nr.",null,"UNINA9910808692603321"]
[null,null,"Titolo",null,"The cell biology of cyanobacteria / / edited by Enrique Flores and Antonia Herrero, Instituto de Bioquimica Vegetal y Fotosintesis CSIC and Universidad de Sevilla, Seville, Spain"]
[null,null,"Pubbl/distr/stampa",null,"Norfolk, England : , : Caister Academic Press, , [2014]"]
[{"$nulls":4},"©2014"]
[null,null,"ISBN",null,"1-908230-92-4"]
[null,null,"Descrizione fisica",null,"1 online resource (320 p.)"]
[null,null,"Disciplina",null,"579.39"]
[null,null,"Soggetti",null,"Cyanobacteria - Molecular aspects"]
[{"$nulls":4},"Cyanobacteria - Cytology"]
[{"$nulls":4},"Cyanobacteria - Physiology"]
[{"$nulls":4},"Cyanobacteria"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references and index."]
[null,null,"Nota di contenuto",null,"Contents; Contributors ; Current books of interest; Preface; 1: A Brief History of Cyanobacterial Research: Past, Present, and Future Prospects; 2: Cell Division in Cyanobacteria; Introduction; Peptidoglycan synthesis and hydrolysis; The cytoskeleton and peptidoglycan synthesis; Identification and analysis of cyanobacterial cell division proteins that are not present in E. coli and B. subtilis; Cyanobacteria-derived components of the chloroplast division machinery; Concluding remarks; 3: The Cell Envelope; The structural properties of the cell envelope"]
[{"$nulls":4},"The outermost layer of the cyanobacterial cell wallThe lipid composition of cyanobacterial membranes; The protein composition of the cyanobacterial cell envelope; Concluding remarks; 4: Proteomics in Revealing the Composition, Acclimation and Biogenesis of Thylakoid Membranes; Introduction; Membrane organization in cyanobacteria; Challenges in proteomic analysis of thylakoids; Proteomic investigations of thylakoid proteins; Proteomics of thylakoid protein complexes; Quantitative proteomics: response of the thylakoid membrane proteome to changes in environmental conditions"]
[{"$nulls":4},"Biogenesis of the thylakoid membrane and protein complexesFuture perspectives; 5: Protein Targeting, Transport and Translocation in Cyanobacteria; Subcellular organization of cyanobacterial cells - the "]
[{"$nulls":4},"sorting problem; How to establish protein heterogeneity in cyanobacteria?; Protein translocation and membrane integration in bacteria and chloroplasts - a brief overview; Protein translocation systems in cyanobacteria: a genetic perspective; Protein translocation systems in cyanobacteria: subcellular localization of translocases and integrases; Targeting signals"]
[{"$nulls":4},"Interactions with soluble factors and targeting proteinsType I signal peptidases; Proteins involved in membrane formation; Transient and/or permanent membrane connections: thylakoid centre and PratA-defined membranes; Models of protein targeting and translocation in cyanobacteria; Epilogue: a heterogenic protein distribution in cyanobacterial subcompartments?; 6: Chromatic Acclimation: a Many-coloured Mechanism for Maximizing Photosynthetic Light Harvesting Efficiency; Introduction; Studies delineating the variation in the types of CA; Cyanobacterial phycobilisomes"]
[{"$nulls":4},"Physiology and regulation of CA3Physiology and regulation of CA2; Physiology and regulation of CA4; Conclusions and future studies; 7: The Carboxysome: Function, Structure and Cellular Dynamics; Introduction; Carboxysome function; Structural and catalytic elements of the carboxysome; Cellular organization and dynamics of carboxysomes; Conclusions and future directions; 8: Glycogen, a Dynamic Cellular Sink and Reservoir for Carbon; Introduction; Structures of glycogen and starch-like reserves in cyanobacteria; Enzymology of glycogen metabolism in cyanobacteria"]
[{"$nulls":4},"Regulation of cyanobacterial glycogen metabolism"]
[null,null,null,"Sommario/riassunto","The cyanobacteria are a fascinating group of bacteria that have adapted to colonize almost every environment on the planet. They are the only prokaryotes capable of oxygenic photosynthesis, responsible for up to 20-30% of Earth's photosynthetic productivity. They can attune their light-harvesting systems to changes in available light conditions, fix nitrogen, and have circadian rhythms. In addition, many cyanobacteria species exhibit gliding mobility and can differentiate into specialized cell types called heterocysts, and some are symbiotic. Thanks to their simple nutritional requirements, th"]
[null,"3.","Record Nr.",null,"UNINA9910751389003321"]
[null,null,"Autore",null,"Chan Anthony T. C"]
[null,null,"Titolo",null,"Immunotherapy for Head and Neck Cancer / / edited by Anthony T. C. Chan, Brigette B.Y. Ma"]
[null,null,"Pubbl/distr/stampa",null,"Cham : , : Springer Nature Switzerland : , : Imprint : Springer, , 2023"]
[null,null,"ISBN",null,"3-031-29223-5"]
[null,null,"Edizione",null,"[1st ed. 2023.]"]
[null,null,"Descrizione fisica",null,"1 online resource (151 pages)"]
[null,null,"Collana",null,"Cancer Immunotherapy, , 2662-8392 ; ; 1"]
[null,null,"Disciplina",null,"615.37"]
[{"$nulls":4},"571.96"]
[null,null,"Soggetti",null,"Immunotherapy"]
[{"$nulls":4},"Oncology"]
[{"$nulls":4},"Medical radiology"]
[{"$nulls":4},"Surgery"]
[{"$nulls":4},"Otolaryngology"]
[{"$nulls":4},"Radiation Oncology"]
[{"$nulls":4},"Otorhinolaryngology"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,"Nota di contenuto",null,"Immunological Landscape of Head and Neck Cancer: Mechanisms of Immune Escape and the Tumor Microenvironment -- Drug Targets and Strategies in the Clinical Development of Immunotherapy for Head and Neck Cancer -- Immunotherapy in Locally Advanced Nasopharyngeal Carcinoma -- Immunotherapy in Recurrent and Metastatic Nasopharyngeal Carcinoma -- Beyond PD-1/PD-L1 Immune Checkpoint Inhibitors: Other Targets and Approaches for Head and Neck Cancer -- Translational and Clinical Approach to Combining Immunotherapy with Radiotherapy in the Treatment of Head and Neck Cancer -- Clinical Application of Immunotherapy in the Perioperative Management of Head and Neck Cancer -- The Role of Immune Checkpoint Inhibitors in the Treatment of Less Common Head and Neck Cancers -- Development of Predictive Biomarkers to Immunotherapy in Head and Neck Cancer. ."]
[null,null,null,"Sommario/riassunto","This book is a comprehensive summary of the literature on the scientific rationale and clinical development of immunotherapy for head and neck cancers. Head and neck cancer is a biologically diverse group of cancers that bear a common hallmark - evasion of host immune "]
[{"$nulls":4},"surveillance through innate or acquired mechanisms. The etiological association between the Human Papilloma virus (HPV) and some squamous head and neck cancers, the Epstein-Barr virus (EBV) and nasopharyngeal cancer has provided further impetus for evaluating immunotherapy in this group of cancers. The successful development of anti-programmed cell death protein-1 (PD-1)/ ligand (PD-L1) and CTLA-4 antibodies in solid tumours has gradually brought immunotherapy into mainstream oncological practice in recent years. Besides immune-checkpoint proteins inhibitors, other forms of immunotherapy such as vaccines, EBV or HPV-targeting therapies and cellular therapies are actively being investigated in clinical trials, either alone or in combination with other conventional treatments such as radiotherapy, chemotherapy and surgery. In clinical setting, the practicing oncologist need to be familiar with some unusual patterns of immunological response such as pseudo-progression and hyper-progression in patients with head and neck cancers who are undergoing treatment with immune-checkpoint inhibitors. Furthermore, the unique side effects of immune-checkpoint inhibitors such as autoimmune toxicities need to be recognized early and treated expediently. The development of biomarkers in predicting response to immune-checkpoint inhibitors has played pivotal roles in selecting patients for immunotherapy in practice or as an enrichment strategy in clinical trials. There are now emerging data on the clinical utility of biomarkers such as PD-L1 expression (Combined Positive Score), gene signatures and tumor mutational burden. This book is an invaluable companion to all those who are involved in research and clinical management of patients with head and neck cancers from any endemic regions. ."]