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[null,"1.","Record Nr.",null,"UNINA9910793945103321"]
[null,null,"Autore",null,"Boone Mary Elizabeth"]
[null,null,"Titolo",null,"\"The Spanish Element in Our Nationality\" : Spain and America at the World's Fairs and Centennial Celebrations, 1876-1915 / / M. Elizabeth Boone"]
[null,null,"Pubbl/distr/stampa",null,"University Park, Pennsylvania : , : The Pennsylvania State University Press, , [2019]"]
[{"$nulls":4},"©2019"]
[null,null,"ISBN",null,"0-271-08526-6"]
[{"$nulls":4},"0-271-08524-X"]
[null,null,"Descrizione fisica",null,"1 online resource (xvi, 239 pages :) : illustrations ;"]
[null,null,"Disciplina",null,"907.4"]
[null,null,"Soggetti",null,"Exhibitions - History"]
[{"$nulls":4},"Art, Spanish - 19th century"]
[{"$nulls":4},"Art, Spanish - 20th century"]
[{"$nulls":4},"United States Civilization Spanish influences"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Nota di bibliografia","Includes bibliographical references (pages 205-222) and index."]
[null,null,"Nota di contenuto",null,"Inventing America at the 1876 Philadelphia Centennial -- Defining (and defending) Spain in Barcelona and Paris, 1888 and 1889 -- Marginalizing Spain (and embracing Cuba) at the 1893 Columbian Exposition -- Reasserting Spain in America at the 1910 centennial exhibitions -- Using Spain to ignore Mexicans at the 1915 California fairs."]
[null,null,null,"Sommario/riassunto","\"Uses Spanish participation at a series of international exhibitions to explore the transnational histories of Spain, the United States, Europe, and America in order to understand how and why the Spanishness of U.S. national identity has been subverted, marginalized, and largely forgotten\"--"]
[null,"2.","Record Nr.",null,"UNINA9910298269003321"]
[null,null,"Autore",null,"Baici Antonio"]
[null,null,"Titolo",null,"Kinetics of Enzyme-Modifier Interactions : Selected Topics in the Theory and Diagnosis of Inhibition and Activation Mechanisms / / by Antonio Baici"]
[null,null,"Pubbl/distr/stampa",null,"Vienna : , : Springer Vienna : , : Imprint : Springer, , 2015"]
[null,null,"ISBN",null,"3-7091-1402-0"]
[null,null,"Edizione",null,"[1st ed. 2015.]"]
[null,null,"Descrizione fisica",null,"1 online resource (503 p.)"]
[null,null,"Disciplina",null,"570"]
[{"$nulls":4},"570285"]
[{"$nulls":4},"571.4"]
[{"$nulls":4},"572.6"]
[null,null,"Soggetti",null,"Enzymology"]
[{"$nulls":4},"Proteins"]
[{"$nulls":4},"Bioinformatics"]
[{"$nulls":4},"Computational biology"]
[{"$nulls":4},"Biophysics"]
[{"$nulls":4},"Protein-Ligand Interactions"]
[{"$nulls":4},"Computer Appl. in Life Sciences"]
[{"$nulls":4},"Biological and Medical Physics, Biophysics"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references at the end of each chapters and index."]
[null,null,"Nota di contenuto",null,"Basic Knowledge -- The General Modifier Mechanism -- Taxonomy of Enzyme-Modifier Interactions and the Specific Velocity Plot -- Complements to Enzyme-Modifier Interactions -- The Basic Mechanisms of Inhibition and Nonessential Activation -- Multiple Enzyme-Modifier Interactions -- Multiple Interactions: Essential Activation and Liberation -- Slow-Onset Enzyme Inhibition -- Enzyme Inactivation with a Note on the Significance of Slow Modification Processes.- Dichotomous Keys to Enzyme-Modification Mechanisms. ."]
[null,null,null,"Sommario/riassunto","The kinetic mechanisms by which enzymes interact with inhibitors and activators, collectively called modifiers, are scrutinized and ranked taxonomically into autonomous species in a way similar to that used in the biological classification of plants and animals. The systematization of the mechanisms is based on two fundamental characters: the "]
[{"$nulls":4},"allosteric linkage between substrate and modifier and the factor by which a modifier affects the catalytic constant of the enzyme. Combinations of the physically significant states of these two characters in an ancestor-descendant-like fashion reveal the existence of seventeen modes of interaction that cover the needs of total, partial and fine-tuning modulation of enzyme activity. These interactions comprise five linear and five hyperbolic inhibition mechanisms, five nonessential activation mechanisms and two hybrid species that manifest either hyperbolic inhibition or nonessential activation characteristics depending on substrate concentration. Five essential activation mechanisms, which are taxonomically independent of the mentioned basic species, complete the inventory of enzyme modifiers. Often masked under conventional umbrella terms or treated as anomalous cases, all seventeen basic inhibition and nonessential activation mechanisms are represented in the biochemical and pharmacological literature of this and the past century, either in the form of rapid or slow-onset reversible interactions, or as irreversible modification processes. The full potential of enzyme inhibitors and activators can only be appreciated after elucidating the details of their kinetic mechanisms of action exploring the entire range of physiologically significant reactant concentrations. This book highlights the wide spectrum of allosteric enzyme modification in physiological occurrences as well as in pharmacological and biotechnological applications that embrace simple and multiple enzyme-modifier interactions. The reader is guided in the journey through this still partly uncharted territory with the aid of mechanistically-oriented criteria aimed at showing the logical way towards the identification of a particular mechanism."]