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[null,"1.","Record Nr.",null,"UNISALENTO991002141019707536"]
[null,null,"Titolo",null,"Carrà / [a cura di Gabriele Fantuzzi]"]
[null,null,"Pubbl/distr/stampa",null,"Milano : Fabbri, c1965"]
[null,null,"Descrizione fisica",null,"1 v. ; 36 cm"]
[null,null,"Collana",null,"I maestri del colore ; 52"]
[null,null,"Disciplina",null,"759.5"]
[null,null,"Soggetti",null,"Carrà, Carlo"]
[{"$nulls":4},"Carrà, Carlo"]
[null,null,"Lingua di pubblicazione",null,"Italiano"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,"2.","Record Nr.",null,"UNINA9910791830603321"]
[null,null,"Titolo",null,"Aggressive breast cancer [[electronic resource] /] / Regina H. DeFrina, editor"]
[null,null,"Pubbl/distr/stampa",null,"New York, : Nova Science Publishers, c2010"]
[null,null,"ISBN",null,"1-61761-864-0"]
[null,null,"Descrizione fisica",null,"1 online resource (276 p.)"]
[null,null,"Collana",null,"Cancer etiology, diagnosis and treatments series"]
[null,null,"Disciplina",null,"616.99/449"]
[null,null,"Soggetti",null,"Breast - Cancer"]
[{"$nulls":4},"Breast - Diseases"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references and index."]
[null,null,"Nota di contenuto",null,"\"\"AGGRESSIVE BREAST CANCER \"\"; \"\"AGGRESSIVE BREAST CANCER \"\"; \"\"CONTENTS \"\"; \"\"PREFACE\"\"; \"\"RESEARCH AND REVIEW ARTICLES\"\"; \"\"THE HER2 ONCOGENE IN BREAST  CANCER \"\"; \"\"ABSTRACT \"\"; \"\"INTRODUCTION \"\"; \"\"HER PROTEIN RECEPTORS: SIGNAL TRANSDUCTION AND ONCOGENESIS \"\"; \"\"Intracellular Signaling Pathways \"\"; \"\"HER-Induced Cell Cycle Progression and Survival Pathways \"\"; \"\"OVER EXPRESSION OF HER2 AND THE PROGNOSIS OF INVASIVE BREAST CANCER \"\"; \"\"HER2 as A Prognostic Factor: Node-Positive Versus Node-Negative Disease\"\"; \"\"HER Status and Lymphoid Infiltration \"\""]
[{"$nulls":4},"\"\"HER2 and Progression of Early Breast Cancer Lesions to Invasive Carcinomas\"\"\"\"Relationship Between HER2 and Estrogen Receptor Expression \"\"; \"\"HER2 ABNORMALITIES IN OTHER TYPES OF BREAST MALIGNANCIES \"\"; \"\"HER2 ABNORMALITIES IN OTHER TYPES OF BREAST MALIGNANCIES \"\"; \"\"Evaluating HER2 in Breast Tissue \"\"; \"\"HER2 TARGETED THERAPY IN BREAST CANCER \"\"; \"\"The Role of Trastuzumab in HER2 Overexpressing Breast Cancer \"\"; \"\"The Role of Pertuzumab in HER2 Overexpressing Breast Cancer \"\"; \"\"The Role of Trastuzumab-DM1 in HER2 Overexpressing Breast Cancer \"\""]
[{"$nulls":4},"\"\"Inhibiting Several HER Receptors: The Role of Lapatinib in HER2 Overexpressing Breast Cancer \"\"\"\"Circulating Serum HER2 Levels \"\"; \"\"PROPOSED RESISTANCE TO ANTI-HER2 THERAPIES \"\"; \"\"Altered Receptor-Antibody Interaction \"\"; \"\"Increased Signaling from other Receptors of the HER Family \"\"; \"\"Increased Signaling from other Receptors Activating the MAPK and PI3K Pathways \"\"; \"\"Constitutive Activation of Downstream Effectors \"\"; \"\"HER2 OVEREXPRESSION AND "]
[{"$nulls":4},"CHEMOTHERAPY \"\"; \"\"Anthracyclines \"\"; \"\"Taxanes \"\"; \"\"HER2 OVEREXPRESSION AND HORMONAL THERAPY \"\""]
[{"$nulls":4},"\"\"CNS DISEASE IN HER2 OVEREXPRESSED BREAST CANCER \"\"\"\"CNS Metastases in Adjuvant Trials of Trastuzumab \"\"; \"\"Prognosis of CNS Metastases in HER2 Overexpressing Breast Cancer\"\"; \"\"CONCLUSION \"\"; \"\"REFERENCES\"\"; \"\"MULTI-DRUG RESISTANCE AS A PROBLEM CHALLENGING BREAST CANCER CHEMOTHERAPY \"\"; \"\"ABSTRACT \"\"; \"\"INTRODUCTION\"\"; \"\"1) Non-Cellular MDR Mechanisms \"\"; \"\"2) Cellular MDR Mechanisms: \"\"; \"\"1. Changes in the intracellular accumulation and distribution of the drug \"\"; \"\"1a. Alteration of drug influx \"\"; \"\"1b. Alteration of drug efflux \"\"; \"\"NORMAL TISSUE DISTRIBUTION\"\""]
[{"$nulls":4},"\"\"PHYSIOLOGICAL FUNCTIONS OF P-GP \"\"\"\"PHARMACOLOGICAL FUNCTIONS OF P-GP \"\"; \"\"P-GP SUBSTRATES \"\"; \"\"2. Increase in Drug Detoxification \"\"; \"\"3. Alterations of Drug Targets \"\"; \"\"4. Increase in DNA Repair Mechanism \"\"; \"\"5. Changes in Key Genes Controlling Cell Proliferation \"\"; \"\"5a. Changes in genes responsible for cell cycle control \"\"; \"\"5b. Abrogation of apoptosis \"\"; \"\"6. Micro-Environmental Stress-Mediated Resistance of Solid Tumors \"\"; \"\"7. Cancer Cell Dormancy and Resistant Cancer Stem Cells \"\"; \"\"MODULATION OF MDR PHENOTYPE \"\""]
[{"$nulls":4},"\"\"I. Circumvention of Drug Resistance Induced by P-Gp Pump Protein \"\""]