{"text_format":"2","workbook":"xls","n_sheets":1,"sheets":["report2"],"not_rendered":{"charts":0,"images":0,"macros":0,"external_links":1,"defined_names":2,"comments":0,"pivot_tables":0},"unopened":[],"bounds":{"document_bytes":16777216,"sheet_cells":100000,"run_cost":"one","rows_first":2000,"rows_last":500,"rows_between":2000,"halvings":0,"cell_chars":16384,"cell_head_chars":4096},"cells_cut":0,"cells_raw":0,"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"report2","index":0,"n_rows":28,"n_cols":5,"rows_kept":28,"cut":false,"hidden":false,"merged":[[0,2,0,3],[0,4,0,5],[1,2,1,3],[1,4,1,5],[2,2,2,3],[4,2,4,3],[6,2,6,3],[7,2,7,3],[8,2,8,3],[10,2,10,3],[11,2,11,3],[15,2,15,3],[18,2,18,3],[18,4,18,5],[19,2,19,3],[19,4,19,5],[20,2,20,3],[20,4,20,5],[21,2,21,3],[22,2,22,3],[23,2,23,3],[24,2,24,3],[25,2,25,3]],"flags":["formulas_cached_only"]}
[null,"1.","Record Nr.",null,"UNINA9910788811003321"]
[null,null,"Titolo",null,"PI PAC : pressurized intraperitoneal aerosol chemotherapy : cancer under pressure / / edited by Marc A. Reymond, Wiebke Solass"]
[null,null,"Pubbl/distr/stampa",null,"Berlin, [Germany] ; ; Boston, [Massachusetts] : , : Walter de Gruyter GmbH, , 2014"]
[{"$nulls":4},"©2014"]
[null,null,"ISBN",null,"3-11-036661-4"]
[{"$nulls":4},"3-11-038636-4"]
[null,null,"Descrizione fisica",null,"1 online resource (252 p.)"]
[null,null,"Disciplina",null,"616.99/4061"]
[null,null,"Soggetti",null,"Antineoplastic agents"]
[{"$nulls":4},"Aerosol"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references at the end of each chapters and index."]
[null,null,"Nota di contenuto",null,"Front matter -- Preface -- Acknowledgments -- Contents -- 1. Introduction / Reymond, M. A. -- 2. Peritoneal carcinomatosis: a neglected disease / Reymond, M. A. -- 3. Normal and diseased peritoneum / Solass, W. / Reymond, M. A. -- 4. Diagnosis and staging of peritoneal carcinomatosis / Solass, W. / Reymond, M. A. -- 5. Therapy of peritoneal carcinomatosis / Demtröder, C. / Giger-Pabst, U. / Solass, W. / Reymond, M. A. -- 6. Assessing tumor response in peritoneal carcinomatosis / Solass, W. / Reymond, M. A. -- 7. Principle of therapeutic capnoperitoneum / Reymond, M. A. / Hu, B. / Garcia, A. / Reck, T. / Köckerling, F. / Hess, J. / Morel, P. -- 8. PIPAC Technology / Solass, W. / Hetzel, A. / Schwarz, T. / Nadiradze, G. / Sagynaliev, E. / Reymond, M. A. -- 9. Preclinical experiments / Reymond, M. A. / Tannapfel, A. / Schneider, C. / Scheidbach, H. / Köver, S. / Jung, A. / Reck, T. / Lippert, H. / Köckerling, F. -- 10. First PIPAC in-human application / Solass, W. / Kerb, R. / Mürdter, T. / Giger-Pabst, U. / Strumberg, D. / Tempfer, C. / Zieren, J. / Schwab, M. / Reymond, M. A. -- 11. Renal and liver toxicities / Blanco, A. / Giger-Pabst, U. / Solass, W. / Zieren, J. / Reymond, M. A. -- 12. PIPAC in ovarian cancer / Tempfer, C. B. / Celik, I. / Solass, W. / Buerkle, B. / Giger-Pabst, U. / Zieren, J. / Strumberg, D. / Reymond, M. A. -- 13. PIPAC in gastric cancer / Nadiradze, G. / Solass, W. / Zieren, J. / Strumberg, D. / Reymond, M. A. / Giger-Pabst, U. -- 14. PIPAC in colorectal cancer / "]
[{"$nulls":4},"Giger-Pabst, U. / Solass, W. / Demtröder, C. / Strumberg, D. / Zieren, J. / Reymond, M. A. -- 15. PIPAC in mesothelioma / Solass, W. / Giger-Pabst, U. / Demtröder, C. / Strumberg, D. / Zieren, J. / Reymond, M. A. -- 16. Quality of Life after PIPAC / Odendahl, K. / Solass, W. / Demtröder, C. / Giger-Pabst, U. / Tempfer, C. / Strumberg, D. / Münker, A. / Reymond, M. A. -- 17. PIPAC and HIPEC / Reymond, M. A. -- 18. Pressurized IntraThoracic Aerosol Chemotherapy (PITAC) / Jonscher, N. / Hummels, M. / Giger-Pabst, U. / Karljalainen, E. / Zieren, J. / Büchner, N. / Reymond, M. A. / Beshay, M. -- 19. Future applications of therapeutic capnoperitoneum / Khalili-Harbi, N. / Herbette, A. / Solass, W. / Giger-Pabst, U. / Engin, E. / Giese, A. / Dutreix, M. / Reymond, M. A. -- 20. Occupational health and safety aspects / Solass, W. / Giger-Pabst, U. / Zieren, J. / Reymond, M. A. -- 21. PIPAC: Risks and dangers / Giger-Pabst, U. / Reymond, M. A. -- 22. Outlook / Reymond, M. A. -- 23. How to start a PIPAC program at your own institution? / Giger-Pabst, U. / Reymond, M. A. -- 24. Training and Standard Operating Procedures / Giger-Pabst, U. / Reymond, M. A. -- Index"]
[null,null,null,"Sommario/riassunto","Peritoneal dissemination is a common route of cancer metastasis. The benefit of administering chemotherapy directly into the peritoneal cavity is supported by preclinical and pharmacokinetic data. In comparison to intravenous (IV) treatment, intraperitoneal (IP) administration results in a several-fold increase in drug concentration within the abdominal cavity. There is now growing evidence from clinical studies showing a survival advantage for IP chemotherapy in various tumor typies, including ovarian, gastric and colorectal cancer. However, while the use of IP chemotherapy is slowly gaining acceptance, it is not universal, largely due to the greater toxicity associated with this approach. Moreover, efficacy of IP chemotherapy is limited by poor distribution within the abdominal cavity and by poor tissue penetration. A new way of IP chemotherapy is the application of cytotoxics in form of a pressurized aerosol into the abdominal of thoracic cavity. Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is applied through laparoscopic access using two balloon trocars in an operating room equipped with laminar air-flow. In a first step,a normothermic capnoperitoneum is established with a pressure of 12 mmHg. A cytotoxic solution (about 10% of a normal systemic dose) is nebulized with a micropump into the abdominal cavity, and maintained for 30 min. The aerosol is then removed through a closed suction system. Applying an aerosol in the peritoneal cavity allows a homogeneous distribution of the chemotherapeutic agent within the abdomen. Furthermore, an artificial pressure gradient is generated that overcomes tumoral interstitial fluid pressure, an obstacle in cancer therapy. This results in a higher local drug concentration compared to conventional IP or IV chemotherapy. At the same time the plasma concentration of the chemotherapeutic agent remains low.  In first clinical studies with limited number of patients in ovarian, gastric and colorectal cancer, as well as peritoneal mesothelioma, PIPAC has obtained encouraging tumor response rates and survival, with a low-side effects profile. Larger clinical trials are currently ongoing to examine if these data can be reproduced and extrapolated to other situations."]
[null,"2.","Record Nr.",null,"UNINA9910158831503321"]
[null,null,"Autore",null,"Priestley Sabine"]
[null,null,"Titolo",null,"Alien Bond"]
[null,null,"Pubbl/distr/stampa",null,"KAC Publishing"]
[null,null,"ISBN",null,"1-62517-956-1"]
[null,null,"Descrizione fisica",null,"1 online resource (26 p.)"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Sommario/riassunto","A short story SciFi Alien Romance. A sequel to the Alien Attachments novel series. After the fall of their empire, the Sandarians struggled for order and peace, hiding their existence from the people of Earth. Until now. Under the guardianship of the Sandarians, it is a new world where fleets of ships circle the globe to protect the vulnerable human race. Kara Heroshi breaks free from a controlling adoptive mother to begin a new life in London. She is both captivated and fearful of the alien Sandarian ship shining above the skyline of London-a beacon of power and allure. Torril Anantha struggles to acclimate himself to life on Earth. The frailty of humanity disturbs him. But when one black-haired beauty ensnares his senses as well as his heart, he finally faces the difficult truth-his psi-mate is human. While Kara is lured by the seductive Sandarian male, can she overcome her fears of being controlled and solidify the bond with Torril-the alien who is fated as her one true mate?"]