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[null,"1.","Record Nr.",null,"UNINA9910787839903321"]
[null,null,"Autore",null,"Valentine Raymond C"]
[null,null,"Titolo",null,"Human Longevity"]
[null,null,"Pubbl/distr/stampa",null,"CRC Press, 2014"]
[null,null,"ISBN",null,"0-429-16877-2"]
[{"$nulls":4},"1-4665-9487-X"]
[null,null,"Descrizione fisica",null,"1 online resource (248 p.)"]
[null,null,"Classificazione",null,"MED008000SCI049000TEC012000"]
[null,null,"Disciplina",null,"612.6/7"]
[null,null,"Soggetti",null,"Aging - Genetic aspects"]
[{"$nulls":4},"Mitochondria"]
[{"$nulls":4},"Oxidative stress"]
[{"$nulls":4},"Omega-3 fatty acids - Health aspects"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references at the end of each chapters."]
[null,null,"Nota di contenuto",null,"Chapter 5: Remarkable Longevity of Queens of Social Insects Likely Involves Dietary Manipulation to Minimize Levels of Polyunsaturates and Decrease Membrane PeroxidationChapter 6: Membrane Peroxidation Hypothesis Helps Explain Longevity in Birds, Rodents, and Whales; Chapter 7: Did Longevity Help Humans Become Super Humans?; Chapter 8: Mitochondrial Diseases and Aging Have Much in Common; Chapter 9: Revised Mitochondrial Hypothesis of Aging Highlights Energy Deficiency Caused by Errors of Replication (Mutations) of mtDNA; Chapter 10: Benefits of Polyunsaturated Mitochondrial Membranes"]
[{"$nulls":4},"Chapter 16: Uncoupling Proteins (UCPs) of Mitochondria Purposely Waste Energy to Prevent Membrane DamageChapter 17: Mitochondrial Fission Protects against Oxidative Stress by Minting a Continuous Supply of Cardiolipin and Other Polyunsaturated Phospholipids; Chapter 18: Mitophagy Eliminates Toxic Mitochondria; Chapter 19: Longevity Genes Likely Protect Membranes; Chapter 20: Aging as a Cardiolipin Disease That Can Be Treated; Back Cover"]
[null,null,null,"Sommario/riassunto","More than 7 billion people inhabit the earth and all of them are subject to aging. This book is aimed at persons interested in a molecular explanation of how our cells age. Human Longevity: Omega-3 Fatty Acids, Bioenergetics, Molecular Biology, and Evolution is built on the proposition that we age as our mitochondria age. It suggests a revised version of Harman's famous hypothesis featuring mitochondrial "]
[{"$nulls":4},"oxidative and energy stresses as the root causes of aging. Human cells are protected from the ravages of aging by a battery of defensive systems including some novel mechanisms against membran"]