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[null,"1.","Record Nr.",null,"UNINA9910787001503321"]
[null,null,"Titolo",null,"Leishmania : current biology and control / / edited by Subrata Adak and Rupak Datta"]
[null,null,"Pubbl/distr/stampa",null,"Norfolk, England : , : Caister Academic Press, , [2015]"]
[{"$nulls":4},"©2015"]
[null,null,"ISBN",null,"1-908230-53-3"]
[null,null,"Descrizione fisica",null,"1 online resource (258 p.)"]
[null,null,"Disciplina",null,"593.18"]
[null,null,"Soggetti",null,"Leishmania"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references and index."]
[null,null,"Nota di contenuto",null,"Contents; Contributors; Current Books of Interest; Preface; 1: Modulation of Host Cell miRNA Expression During Leishmania Infection and Emergence of miRNA as a New Therapeutic Molecule; miRNA-mediated gene regulation in metazoan animals; miRNA as regulator of cholesterol metabolism in mammals; Cholesterol regulates pathogenesis of Leishmania donovani; Leishmania-mediated changes in cholesterol production in mammals; miRNA expression affected by parasite; Mechanism of miRNA alteration by Leishmania; Factors important for host cell miRNA alteration during infection; miRNA as therapeutic agent"]
[{"$nulls":4},"Future of miRNA as a therapeutic agent against visceral leishmaniasis2: Heat Shock Proteins of Leishmania: Chaperones in the Driver's Seat; Introduction: heat shock proteins; Heat shock proteins in Leishmania spp.; Leishmania and the cell stress; The pitfalls of analogy-based assumptions; The chaperone machinery and signal transduction in Leishmania; Open questions; Future trends; Acknowledgements; 3: Role of Iron in Leishmania-Macrophage Interaction; Introduction; Aqueous chemistry and toxicity of iron; Role of iron in physiology; Role of iron in the host-parasite interaction"]
[{"$nulls":4},"Special need of iron for LeishmaniaMammalian iron homeostasis components important for sequestering iron; Regulation of cellular iron metabolism of mammalian host; Source of host iron and its acquisition systems in Leishmania; Summary and future aspects; 4: Oxidative and Nitrosative Stress Response in Leishmania; Introduction; Sources of superoxide and hydrogen peroxide in Leishmania; Targets of reactive oxygen species in Leishmania; Defence against reactive oxygen species; "]
[{"$nulls":4},"Nitrosative stress in Leishmania; Generation of reactive nitrogen species"]
[{"$nulls":4},"Targets of reactive nitrogen species (RNS) in LeishmaniaCellular defences against nitrosative stress in Leishmania; Conclusion; Future perspectives; 5: Cell Death in a Kinetoplastid Parasite, the Leishmania spp.; Introduction; Life cycle of Leishmania spp.; Treatment of leishmaniasis; Programmed cell death (PCD); Programmed cell death in protozoan parasites; Relevance of studying cell death in Leishmania; Apoptosis in Leishmania; Natural cell death during cell cycle; Induction of cell death by anti-leishmanial drugs; Oxidative stress induced cell death"]
[{"$nulls":4},"Role of apoptotic mimicry and apoptosis in LeishmaniaAutophagy in Leishmania; Future trends; Conclusion; 6: Elucidating the Strategies of Immune Evasion by Leishmania; Introduction; Defying recognition by the host: modulation of Toll-like receptor-mediated signalling; Deactivation of host signalling: mitogen-activated protein (MAP) kinases and phosphatases; Disarming the enemy: inhibition of host microbicidal molecules; Delaying phagosome maturation: buying time for promastigote to amastigote conversion; Creating a favourable environment: polarization of Th (T-helper cell) response"]
[{"$nulls":4},"Suppression of antigen presentation: escaping cytotoxic T-cell response"]
[null,null,null,"Sommario/riassunto","Every year, with an estimated 1.3 million new cases and more than 20,000 deaths, Leishmaniasis continues to be a menace in countries across the globe. With the absence of an anti-Leishmania vaccine - along with the toxicity of current anti-parasite drugs and coupled with the rapid emergence of drug resistant Leishmania strains - there remains significant challenges for disease control. This has spurred a plethora of research initiatives into parasite biology, parasite-host interaction, mechanisms of disease pathogenesis, drug development, and the molecular mechanism of drug resistance. Insight"]