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[null,"1.","Record Nr.",null,"UNINA9910137237503321"]
[null,null,"Autore",null,"Tapia Ricardo"]
[null,null,"Titolo",null,"Cellular and molecular mechanisms of motor neuron death in amyotrophic lateral sclerosis [[electronic resource] /] / Ricardo Tapia"]
[null,null,"Pubbl/distr/stampa",null,"Frontiers Media SA, 2015"]
[{"$nulls":4},"France : , : Frontiers Media SA, , 2015"]
[null,null,"ISBN",null,"9782889193769 (ebook)"]
[null,null,"Descrizione fisica",null,"1 online resource (190 pages) : illustrations"]
[null,null,"Collana",null,"Frontiers Research Topics, , 1664-8714"]
[null,null,"Soggetti",null,"Neurology"]
[{"$nulls":4},"Medicine"]
[{"$nulls":4},"Health & Biological Sciences"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Bibliographic Level Mode of Issuance: Monograph"]
[null,null,null,"Nota di bibliografia","Includes bibliographical references."]
[null,null,null,"Sommario/riassunto","Amyotrophic lateral sclerosis (ALS), which was described since 1869 by Jean Martin Charcot, is a devastating neurodegenerative disease characterized by the selective and progressive loss of upper and lower motor neurons of the cerebral cortex, brainstem and the spinal cord. The cognitive process is not affected and is not merely the result of aging because may occur at young ages. The only known cause of the disease is associated with genetic mutations, mainly in the gene encoding superoxide dismutase 1 (familial ALS), whereas there is no known cause of the sporadic form of ALS (SALS), which comprises >90% of cases. Both ALS types develop similar histopathological and clinical characteristics, and there is no treatment or prevention of the disease. Because effective treatments for ALS, as for other neurodegenerative diseases, can only result from the knowledge of their cellular and molecular pathophysiological mechanisms, research on such mechanisms is essential. Although progress in neurochemical, physiological and clinical investigations in the last decades has identified several mechanisms that seem to be involved in the cell death process, such as glutamate-mediated excitotoxicity, alterations of inhibitory circuits, inflammatory events, axonal transport deficits, oxidative stress, mitochondrial dysfunction and energy failure, the understanding of the origin and temporal progress of the disease is still incomplete and insufficient. Clearly, there is a need of further "]
[{"$nulls":4},"experimental models and approaches to discern the importance of such mechanisms and to discover the factors that determine the selective death of motor neurons characteristic of ALS, in contrast to other neurodegenerative diseases such as Parkinson’s and Alzheimer’s disease. Whereas studies in vitro in cell cultures, tissue slices or organotypic preparations can give useful information regarding cellular and molecular mechanisms, the experiments in living animal models obviously reflect more closely the situation in the human disease, provided that the symptoms and their development during time mimics as close as possible those of the human disease. It is necessary to correlate the experimental findings in vitro with those in vivo, as well as those obtained in genetic models with those in non-genetic models, aiming at designing and testing therapeutic strategies based on the results obtained."]
[null,"2.","Record Nr.",null,"UNINA990006696580403321"]
[null,null,"Titolo",null,"Il pensiero di Bertrand Russell. Una antologia dagli scritti / a cura di Enrico Musacchio"]
[null,null,"Pubbl/distr/stampa",null,"Torino, : Loescher, 1972"]
[null,null,"Descrizione fisica",null,"22 cm, pp. XXXIV+347"]
[null,null,"Locazione",null,"FLFBC"]
[{"$nulls":4},"FSPBC"]
[{"$nulls":4},"DDCIC"]
[{"$nulls":4},"DINEL"]
[null,null,"Collocazione",null,"P.1 9W RUS/S 10"]
[{"$nulls":4},"II A 101"]
[{"$nulls":4},"TT 271"]
[{"$nulls":4},"10 DO 53 TA"]
[null,null,"Lingua di pubblicazione",null,"Italiano"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,"3.","Record Nr.",null,"UNINA9910785753203321"]
[null,null,"Autore",null,"Cantor Louis"]
[null,null,"Titolo",null,"Dewey and Elvis [[electronic resource] ] : the life and times of a rock 'n' roll deejay / / Louis Cantor"]
[null,null,"Pubbl/distr/stampa",null,"Urbana, Ill., : University of Illinois Press, c2005"]
[null,null,"ISBN",null,"1-283-13563-9"]
[{"$nulls":4},"9786613135636"]
[{"$nulls":4},"0-252-09073-X"]
[null,null,"Descrizione fisica",null,"1 online resource (321 p.)"]
[null,null,"Collana",null,"Music in American life"]
[null,null,"Disciplina",null,"782.42166/092"]
[{"$nulls":4},"B"]
[null,null,"Soggetti",null,"Disc jockeys"]
[{"$nulls":4},"Rock music - Tennessee - Memphis - History and criticism"]
[{"$nulls":4},"Popular culture - United States"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references (p. [265]-276) and index."]
[null,null,"Nota di contenuto",null,"\"\"Cover\"\"; \"\"Title Page\"\"; \"\"Copyright Page\"\"; \"\"Contents\"\"; \"\"Acknowledgments\"\"; \"\"Introduction\"\"; \"\"1. Programmed Chaos: Dewey Phillips on the Air\"\"; \"\"2. Before the Storm: Dewey Arrives at the Five-and-Dime\"\"; \"\"3. The White Brother on Beale Street\"\"; \"\"4. The New Memphis Sound: The Birth of Black Programming\"\"; \"\"5. \"\"What in the World Is That?\"\" Is This Guy Black or White?\"\"; \"\"6. Racial Cross-Pollination: Black and White Together\"\"; \"\"7. The Great Convergence: Pop Tuner' One-Stop\"\"; \"\"8. The Phillips Boys: Soul (Better than Blood) Brothers\"\""]
[{"$nulls":4},"\"\"9. Red, Hot and Blue: The Hottest Cotton-Pickin' Thang in the Country\"\"\"\"10. Dewey and Elvis: The Synthesized Sound\"\"; \"\"11. Dewey Introduces Elvis to the World\"\"; \"\"12. The King and His Court Jester: Men-Children in the Promised Land\"\"; \"\"13. \"\"Red Hot at First . . . Blue at the Very End\"\"\"\"; \"\"14. The Final Descent: \"\"If Dewey Couldn't be Number One, He Didn''t Wanna Be\"\"\"\"; \"\"15. \"\"Goodbye, Good People\"\"\"\"; \"\"16. The Legacy: The Next Generation and Beyond\"\"; \"\"Epilogue\"\"; \"\"Notes\"\"; \"\"Bibliography\"\"; \"\"Index\"\"; \"\"Illustrations follow page 86\"\"; \"\"Illustrations follow page 158\"\""]