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[null,"1.","Record Nr.",null,"UNICAMPANIASUN0066003"]
[null,null,"Autore",null,"Grassi, Walter"]
[null,null,"Titolo",null,"La certificazione energetica degli edifici e degli impianti : guida tecnica all'applicazione del d.lgs. 192-2005 in materia di rendimento energetico nell'edilizia / Walter Grassi, Gianpaolo Scatizzi, Francesca Venturelli"]
[null,null,"Pubbl/distr/stampa",null,"Santarcangelo di Romagna : Maggioli, 2007"]
[null,null,"ISBN",null,"978-88-387-3825-4"]
[null,null,"Edizione",null,"[2. ed. aggiornata al d. lgs. 311-2006 e al d.m. 19 febbraio 2007]"]
[null,null,"Descrizione fisica",null,"357 p. : ill. ; 30 cm."]
[null,null,"Disciplina",null,"696"]
[null,null,"Lingua di pubblicazione",null,"Italiano"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,"2.","Record Nr.",null,"UNINA9910784842603321"]
[null,null,"Titolo",null,"Preclinical development handbook Toxicology [[electronic resource] /] / [edited by] Shayne Cox Gad"]
[null,null,"Pubbl/distr/stampa",null,"Hoboken, NJ, : Wiley-Interscience, c2008"]
[null,null,"ISBN",null,"1-281-23742-6"]
[{"$nulls":4},"9786611237424"]
[{"$nulls":4},"0-470-24905-6"]
[{"$nulls":4},"0-470-24904-8"]
[null,null,"Descrizione fisica",null,"1 online resource (1075 p.)"]
[null,null,"Collana",null,"Pharmaceutical Development Series ; ; v.4"]
[null,null,"Disciplina",null,"615.7"]
[{"$nulls":4},"615.7040724"]
[{"$nulls":4},"615.9"]
[null,null,"Soggetti",null,"Drugs - Toxicology"]
[{"$nulls":4},"Drugs - Toxicity testing"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references and index."]
[null,null,"Nota di contenuto",null,"PRECLINICAL DEVELOPMENT HANDBOOK Toxicology; CONTRIBUTORS; CONTENTS; Preface; 1 Preclinical Drug Development Planning; 2 Use of Project Teams in Preclinical Development; 3 Relationship between Animal Models and Clinical Research: Using Mucositis as a Practical Example; 4 Bacterial Mutation Assay; 5 In Vitro Mammalian Cell Mutation Assays; 6 In Vitro Mammalian Cytogenetic Tests; 7 In Vivo Genotoxicity Assays; 8 Repeat Dose Toxicity Studies; 9 Irritation and Local Tissue Tolerance Studies in Pharmacetical Safety Assessment; 10 Safety Assessment Studies: Immunotoxicity"]
[{"$nulls":4},"11 Immunotoxicity Testing: ICH Guideline S8 and Related Aspects12 Reproductive and Developmental Toxicology; 13 Carcinogenicity Studies; 14 Toxicokinetics: An Integral Component of Preclinical Toxicity Studies; 15 In Vitro Toxicokinetics and Dynamics: Modeling and Interpretation of Toxicity Data; 16 Toxicologic Pathology; 17 Secondary Pharmacodynamic Studies and In Vitro Pharmacological Profiling; 18 Current Practices in Safety Pharmacology; 19 Safety Assessment of Biotechnology-Derived Therapeutics; 20 Preclinical Development of Protein Pharmaceuticals: An Overview"]
[{"$nulls":4},"21 The Pharmacogenomics of Personalized Medicine22 Genomics; 23 Proteomics; 24 Toxicogenomics in Preclinical Development; 25 "]
[{"$nulls":4},"Toxicoproteomics: Preclinical Studies; 26 Regulatory Considerations; 27 Regulatory Issues in Preclinical Safety Studies (U.S. FDA); 28 Selection and Utilization of CROs for Safety Assessment; 29 Auditing and Inspecting Preclinical Research and Compliance with Good Laboratory Practice (GLP); 30 Drug Impurities and Degradants and Their Safety Qualification; 31 Bridging Studies in Preclinical Pharmaceutical Safety Assessment; Index"]
[null,null,null,"Sommario/riassunto","A clear, straightforward resource to guide you through preclinical drug developmentFollowing this book's step-by-step guidance, you can successfully initiate and complete critical phases of preclinical drug development. The book serves as a basic,comprehensive reference to prioritizing and optimizing leads, toxicity, pharmacogenomics, modeling, and regulations. This single definitive, easy-to-use resource discusses all the issues that need consideration and provides detailed instructions for current methods and techniques.Each chapter was written by one or more leading experts"]