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[null,null,"Autore",null,"Kenakin Terrence P"]
[null,null,"Titolo",null,"A pharmacology primer [[electronic resource] ] : theory, applications, and methods / / Terry Kenakin"]
[null,null,"Pubbl/distr/stampa",null,"Burlington, MA ; ; London, : Academic Press, c2006"]
[null,null,"ISBN",null,"1-280-70765-8"]
[{"$nulls":4},"9786610707652"]
[{"$nulls":4},"0-08-046530-7"]
[null,null,"Edizione",null,"[2nd ed.]"]
[null,null,"Descrizione fisica",null,"1 online resource (319 p.)"]
[null,null,"Disciplina",null,"615.1"]
[{"$nulls":4},"615/.7"]
[null,null,"Soggetti",null,"Pharmacology"]
[{"$nulls":4},"Drugs"]
[{"$nulls":4},"Chemicals - Physiological effect"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Previous ed.: London: Elsevier, 2004."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references and  index."]
[null,null,"Nota di contenuto",null,"Front cover; A PHARMACOLOGY PRIMER THEORY, APPLICATION, AND METHODS; Copyright page; Foreword to Second Edition; Foreword to First Edition; Table of contents; Chapter 1. What Is Pharmacology?; 1.1 About This Book; 1.2 What Is Pharmacology?; 1.3 The Receptor Concept; 1.4 Pharmacological Test Systems; 1.5 The Nature of Drug Receptors; 1.6 Pharmacological Intervention and the Therapeutic Landscape; 1.7 System-independent Drug Parameters: Affinity and Efficacy; 1.8 What Is Affinity?; 1.9 The Langmuir Adsorption Isotherm; 1.10 What Is Efficacy?; 1.11 Dose-response Curves"]
[{"$nulls":4},"1.12 Chapter Summary and Conclusions1.13 Derivations: Conformational Selections as a Mechanism of Efficacy; References; Chapter 2. How Different Tissues Process Drug Response; 2.1 Drug Response as Seen Through the ''Cellular Veil''; 2.2 The Biochemical Nature of Stimulus-response Cascades; 2.3 The Mathematical Approximation of Stimulus-response Mechanisms; 2.4 System Effects on Agonist Response: Full and Partial Agonists; 2.5 Differential Cellular Response to Receptor Stimulus; 2.6 Receptor Desensitization and Tachyphylaxis; 2.7 The Measurement of Drug Activity"]
[{"$nulls":4},"2.8 Advantages and Disadvantages of Different Assay Formats2.9 Drug Concentration as an Independent Variable; 2.10 Chapter Summary and Conclusions; 2.11 Derivations; References; Chapter 3. Drug-Receptor "]
[{"$nulls":4},"Theory; 3.1 About This Chapter; 3.2 Drug-Receptor Theory; 3.3 The Use of Mathematical Models in Pharmacology; 3.4 Some Specific Uses of Models in Pharmacology; 3.5 Classical Model of Receptor Function; 3.6 The Operational Model of Receptor Function; 3.7 Two-state Theory; 3.8 The Ternary Complex Model; 3.9 The Extended Ternary Model; 3.10 Constitutive Receptor Activity"]
[{"$nulls":4},"3.11 The Cubic Ternary Complex Model3.12 Chapter Summary and Conclusions; 3.13 Derivations; References; Chapter 4. Pharmacological Assay Formats: Binding; 4.1 The Structure of This Chapter; 4.2 Binding Theory and Experiment; 4.3 Complex Binding Phenomena: Agonist Affinity from Binding Curves; 4.4 Experimental Prerequisites for Correct Application of Binding Techniques; 4.5 Chapter Summary and Conclusions; 4.6 Derivations; References; Chapter 5. Agonists: The Measurement of Affinity and Efficacy in Functional Assays; 5.1 Functional Pharmacological Experiments"]
[{"$nulls":4},"5.2 The Choice of Functional Assays5.3 Recombinant Functional Systems; 5.4 Functional Experiments: Dissimulation in Time; 5.5 Experiments in Real Time Versus Stop Time; 5.6 The Measurement of Agonist Affinity in Functional Experiments; 5.7 Estimates of Relative Efficacy of Agonists in Functional Experiments; 5.8 Chapter Summary and Conclusions; 5.9 Derivations; References; Chapter 6. Orthosteric Drug Antagonism; 6.1 Introduction; 6.2 Kinetics of Drug-Receptor Interaction; 6.3 Surmountable Competitive Antagonism; 6.4 Noncompetitive Antagonism; 6.5 Agonist-Antagonist Hemi-equilibria"]
[{"$nulls":4},"6.6 Resultant Analysis"]
[null,null,null,"Sommario/riassunto","The Second Edition will continue this tradition of better preparing researchers in the basics of pharmacology.  In addition, new human interest material including historical facts in pharmacology will be added.  A new section on therapeutics will help readers identify with diseases and drug treatments.*Over 30 new figures and tables*More human interest information to provide readers with historical facts on pharmacology research*New section on therapeutics to help identify diseases and drug treatments*New section on new biological concepts relevant to pharmacological researc"]