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[null,"1.","Record Nr.",null,"UNINA9910784065803321"]
[null,null,"Titolo",null,"Innovation in the biopharmaceutical industry / / editors, Rifat A. Atun, Desmond Sheridan"]
[null,null,"Pubbl/distr/stampa",null,"Hackensack, N.J., : World Scientific Pub., c2007"]
[null,null,"ISBN",null,"1-281-12179-7"]
[{"$nulls":4},"981-277-097-6"]
[{"$nulls":4},"1-62198-030-8"]
[null,null,"Descrizione fisica",null,"1 online resource (153 pages)"]
[null,null,"Disciplina",null,"338.4/76151"]
[null,null,"Soggetti",null,"Pharmaceutical industry - Technological innovations"]
[{"$nulls":4},"Pharmaceutical biotechnology"]
[{"$nulls":4},"Biopharmaceutics"]
[{"$nulls":4},"Drug development"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Nota di bibliografia","Includes bibliographical references and index."]
[null,null,"Nota di contenuto",null,"CONTENTS; Acknowledgements; Introduction Innovation in Health Care: The Engine of Technological Advances R. A. Atun and D. Sheridan; Innovation Models in the Biopharmaceutical Sector J. Attridge; Development and Innovation in Cardiovascular Medicine D. Sheridan; Development and Innovation in Cancer Medicine K. Sikora; Innovation, Patents and Economic Growth R. A. Atun, I. Harvey and J. Wild; Uptake and Diffusion of Pharmaceutical Innovations in Health Systems R. A. Atun, I. Gurol-Urganci and D. Sheridan; Partnership and Innovation in the Life Sciences D. Kleyn, R. Kitney and R. A. Atun; Index"]
[null,null,null,"Sommario/riassunto","Innovation is at the heart of all advances and has the capacity to solve problems facing humanity. Societies which have turned away from innovation and technological development have failed in their ability to support their populations. Understanding the nature of innovation in the life sciences and in particular healthcare, how it operates, what enables and hinders it is therefore of great importance to meeting the challenges ahead."]
[null,"2.","Record Nr.",null,"UNINA9910337899703321"]
[null,null,"Autore",null,"Rapp Donald"]
[null,null,"Titolo",null,"Ice Ages and Interglacials : Measurements, Interpretation, and Models / / by Donald Rapp"]
[null,null,"Pubbl/distr/stampa",null,"Cham : , : Springer International Publishing : , : Imprint : Springer, , 2019"]
[null,null,"ISBN",null,"3-030-10466-4"]
[null,null,"Edizione",null,"[3rd ed. 2019.]"]
[null,null,"Descrizione fisica",null,"1 online resource (362 pages)"]
[null,null,"Disciplina",null,"551.6"]
[null,null,"Soggetti",null,"Atmospheric science"]
[{"$nulls":4},"Climatology"]
[{"$nulls":4},"Astronomy"]
[{"$nulls":4},"Astrophysics"]
[{"$nulls":4},"Oceanography"]
[{"$nulls":4},"Atmospheric Sciences"]
[{"$nulls":4},"Astronomy, Astrophysics and Cosmology"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,"Nota di contenuto",null,"Preface -- 1. History and Description of Ice Ages -- 2. Variability of the Earth's climate -- 3. Ice core methodology -- 4. Ice core data -- 5. Ocean sediment data. etc."]
[null,null,null,"Sommario/riassunto","It is not so long ago (a mere 17,000 years – a blink in geologic time) that vast areas of the Northern Hemisphere were covered with ice sheets up to two miles thick, lowering the oceans by more than 120 m. By 11,000 years ago, most of the ice was gone. Evidence from polar ice cores and ocean sediments show that Ice Ages were persistent and recurrent over the past 800,000 years. The data suggests that Ice Ages were the normal state, and were temporarily interrupted by interglacial warm periods about nine times during this period. Quasi-periodic variations in the Earth cause the solar input to high northern latitudes to vary with time over thousands of years. The widely accepted Milankovitch theory implies that the interglacial warm periods are associated with high solar input to high northern latitudes. However, many periods of high solar input to high northern latitudes occur during Ice Ages while the ice sheets remain. The data also indicates that Ice Ages will persist regardless of solar input to high northern latitudes, until several conditions are met that are necessary to "]
[{"$nulls":4},"generate a termination of an Ice Age. An Ice Age will not terminate until it has been maturing for many tens of thousands of years leading to a reduction of the atmospheric CO2 concentration to less than 200 ppm. At that point, CO2 starvation coupled with lower temperatures will cause desertification of marginal regions, leading to the generation of large quantities of dust. High winds transfer this dust to the ice sheets greatly increasing their solar absorptivity, and at the next up-lobe in the solar input to high northern latitudes, solar power melts the ice sheets over about a 6,000-year interval. A warm interglacial period follows, during which dust levels drop remarkably. Slowly but surely, ice begins accumulating again at high northern latitudes and an incipient new Ice Age begins. This third edition presents data and models to support this theory."]